ID   URIC_SCHPO              Reviewed;         296 AA.
AC   O74409;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=Probable uricase;
DE            EC=1.7.3.3;
DE   AltName: Full=Urate oxidase;
GN   ORFNames=SPCC1223.09;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Catalyzes the oxidation of uric acid to 5-
CC       hydroxyisourate, which spontaneously decomposes to form allantoin
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Urate + O(2) + H(2)O = 5-hydroxyisourate +
CC       H(2)O(2).
CC   -!- PATHWAY: Purine metabolism; uric acid degradation; (S)-allantoin
CC       from uric acid: step 1/3.
CC   -!- SIMILARITY: Belongs to the uricase family.
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DR   EMBL; CU329672; CAA20878.1; -; Genomic_DNA.
DR   PIR; T40869; T40869.
DR   RefSeq; NP_588354.1; -.
DR   HSSP; Q00511; 1UOX.
DR   GeneID; 2538957; -.
DR   KEGG; spo:SPCC1223.09; -.
DR   NMPDR; fig|4896.1.peg.692; -.
DR   GeneDB_Spombe; SPCC1223.09; -.
DR   OMA; O74409; KTTQSGF.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-000274-MON; -.
DR   BRENDA; 1.7.3.3; 653.
DR   ArrayExpress; O74409; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB_SPombe.
DR   GO; GO:0004846; F:urate oxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006144; P:purine base metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002042; Uricase.
DR   InterPro; IPR019842; Uricase_CS.
DR   Gene3D; G3DSA:3.10.270.10; Uricase; 1.
DR   PANTHER; PTHR10395:SF1; Uricase; 1.
DR   Pfam; PF01014; Uricase; 2.
DR   PRINTS; PR00093; URICASE.
DR   ProDom; PD003367; Uricase; 2.
DR   TIGRFAMs; TIGR03383; urate_oxi; 1.
DR   PROSITE; PS00366; URICASE; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Oxidoreductase; Purine metabolism.
FT   CHAIN         1    296       Probable uricase.
FT                                /FTId=PRO_0000165998.
FT   REGION      229    230       Substrate binding (By similarity).
FT   ACT_SITE    180    180       Charge relay system (By similarity).
FT   ACT_SITE    230    230       Charge relay system (By similarity).
FT   BINDING      61     61       Substrate (By similarity).
FT   BINDING     180    180       Substrate (By similarity).
SQ   SEQUENCE   296 AA;  33610 MW;  C7C8DF71A7CD1EDF CRC64;
     MSETTYVKQC AYGKTLVRFM KKDICPKTKT HTVYEMDVQS LLTGELEESY TKADNSIVVP
     TDTQKNTIYV FAKNNDVSVP EVFAAKLAKH FVDKYKHIHG AALDITITPW TRMEVQGKPH
     SHSFIRNPGE TRKTHVVFSE GKGFDVVSSL KDVLVLKSTG SGFTNFHKCE FTTLPEVTDR
     IFSTSIDCNY TFKHFDTFEE LAGFDFNSIY EKVKEITLET FALDDSESVQ ATMYKMADTI
     INTYPAINEV YYALPNKHYF EINLAPFNID NLGSNCSLYQ PQAYPSGYIT CTVARK
//