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Protein

Aspartate--tRNA ligase, cytoplasmic

Gene

dps1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei287 – 2871AspartateBy similarity
Binding sitei331 – 3311AspartateBy similarity
Binding sitei502 – 5021ATPBy similarity
Binding sitei505 – 5051AspartateBy similarity
Binding sitei509 – 5091AspartateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi331 – 3333ATPBy similarity
Nucleotide bindingi339 – 3413ATPBy similarity
Nucleotide bindingi551 – 5544ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate--tRNA ligase, cytoplasmic (EC:6.1.1.12)
Alternative name(s):
Aspartyl-tRNA synthetase
Short name:
AspRS
Gene namesi
Name:dps1
ORF Names:SPCC1223.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.07c.
PomBaseiSPCC1223.07c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Aspartate--tRNA ligase, cytoplasmicPRO_0000315951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei282 – 2821Phosphoserine1 Publication
Modified residuei307 – 3071Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74407.

PTM databases

iPTMnetiO74407.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4678804.

Structurei

3D structure databases

ProteinModelPortaliO74407.
SMRiO74407. Positions 70-580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni309 – 3124AspartateBy similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000226032.
InParanoidiO74407.
KOiK01876.
OMAiAIAGDME.
OrthoDBiEOG092C04LM.
PhylomeDBiO74407.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004523. Asp-tRNA_synthase_arc.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 3 hits.
PTHR22594:SF33. PTHR22594:SF33. 3 hits.
PfamiPF00152. tRNA-synt_2. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00458. aspS_nondisc. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
PS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEMEKQVEN LSLEAKNEKP KEVILGEDGK PLSKKALKKL EKEREKEQKR
60 70 80 90 100
KEREAREAEE KKKREANEID YSAGKYGDLP LNRSTARPGR TYTQISDISA
110 120 130 140 150
KNDGQTVLLR ARVYTSRLQG NKMCFFSLRQ KYDTIQALAV VNKDTISKQM
160 170 180 190 200
VKWCGSISLE SIVLVEGIVK KSPEIIKSAT VQDAEIHISS IYVISPIKKN
210 220 230 240 250
LPFLVEDAGR SEEQIRESEE NAAEGDSKFV RVNLDTRLDN RVLDLRTPTN
260 270 280 290 300
QAIFDIQAGI CQAFREFLLS NSFNEIHTPK MSGASSEGGS NVFKIQYFKT
310 320 330 340 350
DGFLSQSPQL YKQMLIAADR ERVFEIGPVF RAEDSNTYRH MTEFTGLDLE
360 370 380 390 400
MAFNEHYHEV MEFIEKLFLY IFKTIREKYA KQVAVVRQQY PSEDFILPDA
410 420 430 440 450
DRIRFHFKDA VKLLKEAGYR KQLVPGQKVP EDEEFHYCED PEFDDFSTPE
460 470 480 490 500
ERALGQIVRE KYHTDFYVID KYPSSVRPFY TMPDPEDPRY SNSYDFFMKG
510 520 530 540 550
QEIMSGAQRI HDPELLVERM KALGVSPDVG LQQYIDAFAI GCPPHAGGGI
560 570 580
GLERVVMFYL NLPNIRLASS FPRDPKRLLP
Length:580
Mass (Da):66,671
Last modified:November 1, 1998 - v1
Checksum:i432FCC074D558A4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20876.1.
PIRiT40867.
RefSeqiNP_588352.1. NM_001023343.2.

Genome annotation databases

EnsemblFungiiSPCC1223.07c.1; SPCC1223.07c.1:pep; SPCC1223.07c.
GeneIDi2539278.
KEGGispo:SPCC1223.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20876.1.
PIRiT40867.
RefSeqiNP_588352.1. NM_001023343.2.

3D structure databases

ProteinModelPortaliO74407.
SMRiO74407. Positions 70-580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4678804.

PTM databases

iPTMnetiO74407.

Proteomic databases

MaxQBiO74407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1223.07c.1; SPCC1223.07c.1:pep; SPCC1223.07c.
GeneIDi2539278.
KEGGispo:SPCC1223.07c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.07c.
PomBaseiSPCC1223.07c.

Phylogenomic databases

HOGENOMiHOG000226032.
InParanoidiO74407.
KOiK01876.
OMAiAIAGDME.
OrthoDBiEOG092C04LM.
PhylomeDBiO74407.

Miscellaneous databases

PROiO74407.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004523. Asp-tRNA_synthase_arc.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 3 hits.
PTHR22594:SF33. PTHR22594:SF33. 3 hits.
PfamiPF00152. tRNA-synt_2. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00458. aspS_nondisc. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
PS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYDC_SCHPO
AccessioniPrimary (citable) accession number: O74407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.