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Protein

Heat shock protein 78, mitochondrial

Gene

hsp78

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 1468ATP 1Sequence analysis
Nucleotide bindingi539 – 5468ATP 1Sequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 78, mitochondrial
Gene namesi
Name:hsp78
ORF Names:SPBC4F6.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4F6.17c.
PomBaseiSPBC4F6.17c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3636MitochondrionSequence analysisAdd
BLAST
Chaini37 – 803767Heat shock protein 78, mitochondrialPRO_0000372309Add
BLAST

Proteomic databases

MaxQBiO74402.

Interactioni

Subunit structurei

Homohexamer, forming a ring with a central pore.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277414. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO74402.
SMRiO74402. Positions 93-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 342249NBD1By similarityAdd
BLAST
Regioni465 – 656192NBD2By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili343 – 43189Sequence analysisAdd
BLAST

Domaini

Has 2 AAA ATPase type nucleotide-binding domains (NBDs) per monomer. NBD1 is primarily responsible for ATP hydrolysis. NBD2 is crucial for oligomerization (By similarity).By similarity

Sequence similaritiesi

Belongs to the ClpA/ClpB family.Curated

Keywords - Domaini

Coiled coil, Repeat, Transit peptide

Phylogenomic databases

HOGENOMiHOG000218211.
InParanoidiO74402.
KOiK03695.
OMAiPVERILM.
OrthoDBiEOG092C0JLO.
PhylomeDBiO74402.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILPKSIPI RIQSLRRYQG SLKTSLRALS TRPIFEKRLL AETPFSIRPS
60 70 80 90 100
NASVLIAKRS PKFGWKQVRF YAANPNGGNF RMDLGGGRKQ GAALEEYGTD
110 120 130 140 150
LTALAKQGKL DPVIGREEEI QRTIQILSRR TKNNPALVGP AGVGKTAIME
160 170 180 190 200
GLASRIIRGE VPESMKDKRV IVLDLGALIS GAKFRGDFEE RLKSVLSDLE
210 220 230 240 250
GAEGKVILFV DEMHLLLGFG KAEGSIDASN LLKPALARGK LHCCGATTLE
260 270 280 290 300
EYRKYIEKDA ALARRFQAVM VNEPSVADTI SILRGLKERY EVHHGVRITD
310 320 330 340 350
DALVTAATYS ARYITDRFLP DKAIDLVDEA CSSLRLQQES KPDELRRLDR
360 370 380 390 400
QIMTIQIELE SLRKETDTTS VERREKLESK LTDLKEEQDK LSAAWEEERK
410 420 430 440 450
LLDSIKKAKT ELEQARIELE RTQREGNYAR ASELQYAIIP ELERSVPKEE
460 470 480 490 500
KTLEEKKPSM VHDSVTSDDI AVVVSRATGI PTTNLMRGER DKLLNMEQTI
510 520 530 540 550
GKKIIGQDEA LKAIADAVRL SRAGLQNTNR PLASFLFLGP TGVGKTALTK
560 570 580 590 600
ALAEFLFDTD KAMIRFDMSE FQEKHTIARL IGSPPGYIGY EESGELTEAV
610 620 630 640 650
RRKPYAVLLF DELEKAHHDI TNLLLQVLDE GFLTDSQGRK VDFRSTLIVM
660 670 680 690 700
TSNLGSDILV ADPSTTVTPK SRDAVMDVVQ KYYPPEFLNR IDDQIVFNKL
710 720 730 740 750
SEKNLEDIVN VRLDEVQQRL NDRRIILTVT EAARKWLAEK GYSPAYGARP
760 770 780 790 800
LNRLIQKRIL NTMAMKIIQG EIKSDENVVI DVLDGELEFK ANKLEPQSTS

HED
Length:803
Mass (Da):90,154
Last modified:November 1, 1998 - v1
Checksum:i83C5C413DC2B1F12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20737.1.
PIRiT40514.
RefSeqiNP_596117.1. NM_001022034.2.

Genome annotation databases

EnsemblFungiiSPBC4F6.17c.1; SPBC4F6.17c.1:pep; SPBC4F6.17c.
GeneIDi2540898.
KEGGispo:SPBC4F6.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20737.1.
PIRiT40514.
RefSeqiNP_596117.1. NM_001022034.2.

3D structure databases

ProteinModelPortaliO74402.
SMRiO74402. Positions 93-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277414. 1 interaction.

Proteomic databases

MaxQBiO74402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4F6.17c.1; SPBC4F6.17c.1:pep; SPBC4F6.17c.
GeneIDi2540898.
KEGGispo:SPBC4F6.17c.

Organism-specific databases

EuPathDBiFungiDB:SPBC4F6.17c.
PomBaseiSPBC4F6.17c.

Phylogenomic databases

HOGENOMiHOG000218211.
InParanoidiO74402.
KOiK03695.
OMAiPVERILM.
OrthoDBiEOG092C0JLO.
PhylomeDBiO74402.

Miscellaneous databases

PROiO74402.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP78_SCHPO
AccessioniPrimary (citable) accession number: O74402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.