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Protein

Ribosome biogenesis protein erb1

Gene

erb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein erb1UniRule annotation
Alternative name(s):
Eukaryotic ribosome biogenesis protein 1UniRule annotation
Gene namesi
Name:erb1
ORF Names:SPBC4F6.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4F6.13c
PomBaseiSPBC4F6.13c erb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165691 – 740Ribosome biogenesis protein erb1Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei434Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74399
PaxDbiO74399
PRIDEiO74399

PTM databases

iPTMnetiO74399

Interactioni

Subunit structurei

Component of the NOP7 complex, composed of erb1, ppp1/nop7 and ytm1/SPAC890.04c. The complex is held together by erb1, which interacts with ppp1/nop7 via its N-terminal domain and with ytm1/SPAC890.04c via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.UniRule annotation

Protein-protein interaction databases

BioGridi277405, 4 interactors
STRINGi4896.SPBC4F6.13c.1

Structurei

3D structure databases

SMRiO74399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati381 – 420WD 1Add BLAST40
Repeati526 – 568WD 2Add BLAST43
Repeati571 – 609WD 3Add BLAST39
Repeati612 – 651WD 4Add BLAST40
Repeati655 – 694WD 5Add BLAST40
Repeati710 – 740WD 6Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000029368
InParanoidiO74399
KOiK14824
OMAiSHGMVYN
OrthoDBiEOG092C1381

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03027 BOP1, 1 hit
InterProiView protein in InterPro
IPR028598 BOP1/Erb1
IPR012953 BOP1_N_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR17605 PTHR17605, 1 hit
PfamiView protein in Pfam
PF08145 BOP1NT, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01035 BOP1NT, 1 hit
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

O74399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGMNRKRS RSKRANSNVG VEKDKEKEKS KGVSNVPNEV ETESSSHEPS
60 70 80 90 100
FKKDVDEEIP SLTAELSEEE EGEYSSESGR STPELSPDDF EDADDEEEFE
110 120 130 140 150
EIDAGYSSDS STEDVAPGLY ESPYDENLYI NYDIDGKKIT RPATPAALDS
160 170 180 190 200
LIASIDKDKG WTGIVDPMTG KPVNLTTEEL GLLKRLAQSE IPDENFDPYP
210 220 230 240 250
DYDDFFTNTV RETPLSSAPE PKRRFAPSKH EQKRILQLAY AIRKGRILTS
260 270 280 290 300
EQRAERERES QSNYADHDLW ADDDQATVNQ RKLDYAPAPK LPPPSHEESY
310 320 330 340 350
NPPEEYLKQS SDFPKKYKSL RVVPAYSNLI KEKFERCLDL YLAPRVRRTK
360 370 380 390 400
LNIDPESLLP KLPTPSELRP FPTRCTNVFI GHKGRVRCLS VHVSGNWLAS
410 420 430 440 450
GGDDGVLRIW EVMTGRCVWK CSLDSFGNAH NIDSDEDAVN ESLSHSTKSS
460 470 480 490 500
IIQSLAWGPL SDSPVLAVAV DETVYFITPP IFSDEQIEAS KELFTSAPYQ
510 520 530 540 550
ESSAIWRRGA KQSLQLHGGI VHATVSTPSS IKSLSWHRRG DYLATSSPTS
560 570 580 590 600
SSQAVLIHQL SRGASQSPFS KSKGSVQAVT FHPTMPYLLV ATQRYVRIYN
610 620 630 640 650
LVKQELVKTL LTGVKWVSSL SVHSSGDHVI IGSYDKRLCW FDLDFSSKPY
660 670 680 690 700
KNLRYHSRAL RDVSYHPSLP LFCSGSDDGD VQVFHGRVYS DLLANPLIVP
710 720 730 740
LKILRNHKVV DNVGVLSTCW HPKEAWLFSA GAGGEIRMWT
Length:740
Mass (Da):82,945
Last modified:October 3, 2012 - v2
Checksum:iD352AF12C7A1D0BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA20733.2
PIRiT40510
RefSeqiNP_596113.2, NM_001022030.2

Genome annotation databases

EnsemblFungiiSPBC4F6.13c.1; SPBC4F6.13c.1:pep; SPBC4F6.13c
GeneIDi2540888
KEGGispo:SPBC4F6.13c

Similar proteinsi

Entry informationi

Entry nameiERB1_SCHPO
AccessioniPrimary (citable) accession number: O74399
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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