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Protein

Ribosome biogenesis protein erb1

Gene

erb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein erb1UniRule annotation
Alternative name(s):
Eukaryotic ribosome biogenesis protein 1UniRule annotation
Gene namesi
Name:erb1
ORF Names:SPBC4F6.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4F6.13c.
PomBaseiSPBC4F6.13c. erb1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: PomBase
  • nucleoplasm Source: UniProtKB-SubCell
  • nucleus Source: PomBase
  • PeBoW complex Source: PomBase
  • preribosome, large subunit precursor Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 740740Ribosome biogenesis protein erb1PRO_0000316569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei434 – 4341Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74399.

PTM databases

iPTMnetiO74399.

Interactioni

Subunit structurei

Component of the NOP7 complex, composed of erb1, ppp1/nop7 and ytm1/SPAC890.04c. The complex is held together by erb1, which interacts with ppp1/nop7 via its N-terminal domain and with ytm1/SPAC890.04c via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.UniRule annotation

Protein-protein interaction databases

BioGridi277405. 4 interactions.
MINTiMINT-4678754.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati381 – 42040WD 1Add
BLAST
Repeati526 – 56843WD 2Add
BLAST
Repeati571 – 60939WD 3Add
BLAST
Repeati612 – 65140WD 4Add
BLAST
Repeati655 – 69440WD 5Add
BLAST
Repeati710 – 74031WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation
Contains 6 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000029368.
InParanoidiO74399.
KOiK14824.
OMAiGPANTIG.
OrthoDBiEOG70PC60.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03027. BOP1.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGMNRKRS RSKRANSNVG VEKDKEKEKS KGVSNVPNEV ETESSSHEPS
60 70 80 90 100
FKKDVDEEIP SLTAELSEEE EGEYSSESGR STPELSPDDF EDADDEEEFE
110 120 130 140 150
EIDAGYSSDS STEDVAPGLY ESPYDENLYI NYDIDGKKIT RPATPAALDS
160 170 180 190 200
LIASIDKDKG WTGIVDPMTG KPVNLTTEEL GLLKRLAQSE IPDENFDPYP
210 220 230 240 250
DYDDFFTNTV RETPLSSAPE PKRRFAPSKH EQKRILQLAY AIRKGRILTS
260 270 280 290 300
EQRAERERES QSNYADHDLW ADDDQATVNQ RKLDYAPAPK LPPPSHEESY
310 320 330 340 350
NPPEEYLKQS SDFPKKYKSL RVVPAYSNLI KEKFERCLDL YLAPRVRRTK
360 370 380 390 400
LNIDPESLLP KLPTPSELRP FPTRCTNVFI GHKGRVRCLS VHVSGNWLAS
410 420 430 440 450
GGDDGVLRIW EVMTGRCVWK CSLDSFGNAH NIDSDEDAVN ESLSHSTKSS
460 470 480 490 500
IIQSLAWGPL SDSPVLAVAV DETVYFITPP IFSDEQIEAS KELFTSAPYQ
510 520 530 540 550
ESSAIWRRGA KQSLQLHGGI VHATVSTPSS IKSLSWHRRG DYLATSSPTS
560 570 580 590 600
SSQAVLIHQL SRGASQSPFS KSKGSVQAVT FHPTMPYLLV ATQRYVRIYN
610 620 630 640 650
LVKQELVKTL LTGVKWVSSL SVHSSGDHVI IGSYDKRLCW FDLDFSSKPY
660 670 680 690 700
KNLRYHSRAL RDVSYHPSLP LFCSGSDDGD VQVFHGRVYS DLLANPLIVP
710 720 730 740
LKILRNHKVV DNVGVLSTCW HPKEAWLFSA GAGGEIRMWT
Length:740
Mass (Da):82,945
Last modified:October 3, 2012 - v2
Checksum:iD352AF12C7A1D0BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20733.2.
PIRiT40510.
RefSeqiNP_596113.2. NM_001022030.2.

Genome annotation databases

EnsemblFungiiSPBC4F6.13c.1; SPBC4F6.13c.1:pep; SPBC4F6.13c.
GeneIDi2540888.
KEGGispo:SPBC4F6.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20733.2.
PIRiT40510.
RefSeqiNP_596113.2. NM_001022030.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277405. 4 interactions.
MINTiMINT-4678754.

PTM databases

iPTMnetiO74399.

Proteomic databases

MaxQBiO74399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4F6.13c.1; SPBC4F6.13c.1:pep; SPBC4F6.13c.
GeneIDi2540888.
KEGGispo:SPBC4F6.13c.

Organism-specific databases

EuPathDBiFungiDB:SPBC4F6.13c.
PomBaseiSPBC4F6.13c. erb1.

Phylogenomic databases

HOGENOMiHOG000029368.
InParanoidiO74399.
KOiK14824.
OMAiGPANTIG.
OrthoDBiEOG70PC60.

Miscellaneous databases

PROiO74399.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03027. BOP1.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiERB1_SCHPO
AccessioniPrimary (citable) accession number: O74399
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.