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Protein

Palmitoyltransferase erf2

Gene

erf2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The erf2-erf4 complex is a palmitoyltransferase specific for Ras proteins (By similarity). Has a role in sporulation.By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processSporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase erf2 (EC:2.3.1.225)
Alternative name(s):
DHHC cysteine-rich domain-containing protein erf2
Meiotically up-regulated gene 142 protein
Ras protein acyltransferase
Gene namesi
Name:erf2
Synonyms:mug142
ORF Names:SPBC3H7.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3H7.09.
PomBaseiSPBC3H7.09. erf2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 112LumenalSequence analysis5
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 225CytoplasmicSequence analysisAdd BLAST92
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 270LumenalSequence analysisAdd BLAST24
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 350CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129461 – 350Palmitoyltransferase erf2Add BLAST350

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiO74384.

Interactioni

Subunit structurei

Interacts with erf4.By similarity

Protein-protein interaction databases

BioGridi277573. 42 interactors.
MINTiMINT-4678625.
STRINGi4896.SPBC3H7.09.1.

Structurei

3D structure databases

SMRiO74384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 232DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO74384.
KOiK16675.
OMAiVPWDEPR.
OrthoDBiEOG092C4JRP.
PhylomeDBiO74384.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

O74384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYEKHSDAK ASRYAWNQPW NPFEVTLSDP TYPMNLEEKN QIPYRFQSVP
60 70 80 90 100
DDVPEVPHIE SRYKNLPGNN IYLCCGRLQM SSQYKAFLIS LFALILPGVL
110 120 130 140 150
FFIFSAFWLW HHVSPAVPIT FAYLYALAVV SMFKCSTADP GILPRNAYSL
160 170 180 190 200
TYNPAHPWSV IPEDRKVLVG STRSDSVFVN TVYCHTCHLY RPPRASHCHL
210 220 230 240 250
CDNCVEYLDH HCIWLNTCIG RRNYRYYFIF LLSVVLSALY LTGLGFYTSI
260 270 280 290 300
GSFHESTDTN FAAHLRRPWA GVSFFLGIYG ALGAILPGIL FCYQCYLISV
310 320 330 340 350
GQNVHEYLRA KSTETEDVHP FHDSIWLNFL VVLCRPKNVS YVRPTRKSYV
Length:350
Mass (Da):40,294
Last modified:November 1, 1998 - v1
Checksum:iA9F97E1780DE4445
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20305.1.
PIRiT40406.
RefSeqiNP_595766.1. NM_001021667.2.

Genome annotation databases

EnsemblFungiiSPBC3H7.09.1; SPBC3H7.09.1:pep; SPBC3H7.09.
GeneIDi2541058.
KEGGispo:SPBC3H7.09.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiERFB_SCHPO
AccessioniPrimary (citable) accession number: O74384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1998
Last modified: July 5, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families