Reviewed, UniProtKB/Swiss-Prot O74382 (SERB_SCHPO)

Names and origin

Protein names

Recommended name:
    Probable phosphoserine phosphatase
      Short name=PSPase
      Short name=PSP
    EC=3.1.3.3
Alternative name(s):
    O-phosphoserine phosphohydrolase

Gene names

ORF Names:

SPBC3H7.07c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Pathway	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
Sequence similarities	Belongs to the serB family.
Sequence caution	The sequence BAA13922.1 differs from that shown. Reason: Frameshift at position 267.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Serine biosynthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Probable phosphoserine phosphatase		PRO_0000156884

Sequences

	Sequence		Length	Mass (Da)
	O74382-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 4BCBCE73E9013CA5	FASTA	298	32,411
	10 20 30 40 50 60 MVNAAIVVSS NRPNVLEQIS SLFRDGKTRS LGEQWTLVSG QLKGTFEDAK DACNRISATE 70 80 90 100 110 120 NVDCNCLSEA TFSTKKKLVV FDMDSTLIQQ ECIDELAAEA GIQKEVATIT SLAMNGEIDF 130 140 150 160 170 180 QESLRRRVSL LQGLSVDVIN KVIGKITFTP GAKQLCHCLK QMGATLVVAS GGFVPMAEYV 190 200 210 220 230 240 KGQLDLDYAY ANVLEFSDDG KFLTGKVQGA IVDGQRKASI LREKREELGL NKLETMAVGD 250 260 270 280 290 GANDLVMMAE SGLGIAFKAK PKVQLLADSK INLPSLQNAL YLLGIDEQQQ KKLLENKN

References

[1]

"Identification of open reading frames in Schizosaccharomyces pombe cDNAs." Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H. DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: PR745.

[2]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D89261 mRNA. Translation: BAA13922.1. Frameshift. CU329671 Genomic DNA. Translation: CAA20303.1.
PIR	T40408. T43186.
RefSeq	NP_595768.1.
3D structure databases
SMR	O74382. Positions 74-280.
ModBase	Search...
Protein-protein interaction databases
STRING	O74382.
Genome annotation databases
GeneID	2540968.
KEGG	spo:SPBC3H7.07c.
NMPDR	fig|4896.1.peg.1634.
Organism-specific databases
GeneDB_Spombe	SPBC3H7.07c.
Phylogenomic databases
eggNOG	fuNOG08484.
HOGENOM	HBG645339.
OMA	HVAAITE.
OrthoDB	EOG9XH1GN.
PhylomeDB	O74382.
Enzyme and pathway databases
BRENDA	3.1.3.3. 653.
Gene expression databases
ArrayExpress	O74382.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006383. HAD-SF_hydro_IB_PSP-like. IPR004469. SerB. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01488. HAD-SF-IB. 1 hit. TIGR00338. serB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SERB_SCHPO

Accession

Primary (citable) accession number: O74382
Secondary accession number(s): P78910

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	November 1, 1998
Last modified:	February 9, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)