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O74378 (ODO1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase, mitochondrial

EC=1.2.4.2
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene names
Name:kgd1
ORF Names:SPBC3H7.03c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length1009 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Enzyme regulation

Catabolite repressed By similarity.

Subcellular location

Mitochondrion matrix By similarity Ref.2.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 10099702-oxoglutarate dehydrogenase, mitochondrial
PRO_0000315629

Sequences

Sequence LengthMass (Da)Tools
O74378 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 4CB2598CE2B5E6AB

FASTA1,009114,164
        10         20         30         40         50         60 
MLRFIPSSAK ARALRRSAVT AYRLNRLTCL SSLQQNRTFA TQPTDDFLTG GAADYVDEMY 

        70         80         90        100        110        120 
DAWKKDPNSV HASWQAYFKN VQERGVSPSK AFQAPPLLDY ADSYTALDSS LINGNNYADI 

       130        140        150        160        170        180 
DVGIYMKVQL LVRAYQSRGH HLAKLDPLGI NVNHNRPSEL TLEHYGFTES DLNRTIHLGP 

       190        200        210        220        230        240 
GILPNFREAG RKTMTLREIV ETCEKIYCGS FAVEFTHISS RKRSNWILSH LETPTPFRYS 

       250        260        270        280        290        300 
HDQKIMIFDR LSWADSFERF LFTKFPNDKR FGLEGCEAMV PGMKALIDRS VDEGISNIVI 

       310        320        330        340        350        360 
GMAHRGRLNL LHNIVRKPAQ AIFSEFRGTQ DPDDEGSGDV KYHLGMNYQR PTPSGKRVSL 

       370        380        390        400        410        420 
SLVANPSHLE AEDPVVLGKV RAIQHYTSDE ASHEQSMGIL IHGDAAFAAQ GVVYETFGLH 

       430        440        450        460        470        480 
ALPGYSTGGT VHIVINNQIG FTTDPRFARS TPYCTDIAKS MEAPIFHVNG DDVEAVTFIC 

       490        500        510        520        530        540 
QLAADWRKAF KTDVVVDIVC YRRHGHNETD QPSFTQPRMY KAIAKHPPTF KIYTQQLLQE 

       550        560        570        580        590        600 
KTVSKAEVDA QEKRVWDILE SSFESSKNYK SDHREWLSNP WVGFASPKDL MTKILPSYPT 

       610        620        630        640        650        660 
GVNIDTLKQI GKALYTLPEG FDAHRNLKRI LNNRNKSISS GEGIDMPTAE ALAFGTLLEE 

       670        680        690        700        710        720 
GHHVRVSGQD VERGTFSQRH AVLHDQSSEN VYIPLNHLSP NQASFVIRNS SLSEYGVLGF 

       730        740        750        760        770        780 
EYGYSLSSPN ALVVWEAQFG DFANNAQCII DQFIAAGETK WLQRTGIVLS LPHGYDGQGP 

       790        800        810        820        830        840 
EHSSARMERY LQLCNEDPRE FPSEEKLQRQ HQDCNIQAIY VTKPSQYFHA LRRNIHRQFR 

       850        860        870        880        890        900 
KPLVIFFSKS LLRHPAARST IDEFDEKHGF KLILEEEEHG KSILPPEKIE KLIICSGQVW 

       910        920        930        940        950        960 
VALSKAREEN KIDNIAITRV EQLHPFGWKQ MAANISQYPN LKEIIWCQEE PLNAGAWTYM 

       970        980        990       1000 
EPRIYTILKH LGRDLPVRYA GRPPSASVAA GNKQQHLAEQ EQFLNDALL 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAA20299.1.
PIRT40412.
RefSeqNP_595772.1. NM_001021673.2.

3D structure databases

ProteinModelPortalO74378.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277507. 2 interactions.
MINTMINT-4678582.
STRING4896.SPBC3H7.03c-1.

Proteomic databases

MaxQBO74378.
PaxDbO74378.
PRIDEO74378.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC3H7.03c.1; SPBC3H7.03c.1:pep; SPBC3H7.03c.
GeneID2540991.
KEGGspo:SPBC3H7.03c.

Organism-specific databases

PomBaseSPBC3H7.03c.

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259586.
KOK00164.
OMAQIDKEAR.
OrthoDBEOG72G1GM.
PhylomeDBO74378.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Other

NextBio20802106.
PROO74378.

Entry information

Entry nameODO1_SCHPO
AccessionPrimary (citable) accession number: O74378
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names