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O74378

- ODO1_SCHPO

UniProt

O74378 - ODO1_SCHPO

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Protein
2-oxoglutarate dehydrogenase, mitochondrial
Gene
kgd1, SPBC3H7.03c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

Enzyme regulationi

Catabolite repressed By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: PomBase
  2. tricarboxylic acid cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiREACT_208292. Lysine catabolism.
REACT_213505. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:kgd1
ORF Names:SPBC3H7.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC3H7.03c.

Subcellular locationi

Mitochondrion matrix By similarity 1 Publication

GO - Cellular componenti

  1. mitochondrial nucleoid Source: PomBase
  2. mitochondrial oxoglutarate dehydrogenase complex Source: PomBase
  3. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion Reviewed prediction
Add
BLAST
Chaini40 – 10099702-oxoglutarate dehydrogenase, mitochondrial
PRO_0000315629Add
BLAST

Proteomic databases

MaxQBiO74378.
PaxDbiO74378.
PRIDEiO74378.

Interactioni

Protein-protein interaction databases

BioGridi277507. 2 interactions.
MINTiMINT-4678582.
STRINGi4896.SPBC3H7.03c-1.

Structurei

3D structure databases

ProteinModelPortaliO74378.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiQIDKEAR.
OrthoDBiEOG72G1GM.
PhylomeDBiO74378.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74378-1 [UniParc]FASTAAdd to Basket

« Hide

MLRFIPSSAK ARALRRSAVT AYRLNRLTCL SSLQQNRTFA TQPTDDFLTG     50
GAADYVDEMY DAWKKDPNSV HASWQAYFKN VQERGVSPSK AFQAPPLLDY 100
ADSYTALDSS LINGNNYADI DVGIYMKVQL LVRAYQSRGH HLAKLDPLGI 150
NVNHNRPSEL TLEHYGFTES DLNRTIHLGP GILPNFREAG RKTMTLREIV 200
ETCEKIYCGS FAVEFTHISS RKRSNWILSH LETPTPFRYS HDQKIMIFDR 250
LSWADSFERF LFTKFPNDKR FGLEGCEAMV PGMKALIDRS VDEGISNIVI 300
GMAHRGRLNL LHNIVRKPAQ AIFSEFRGTQ DPDDEGSGDV KYHLGMNYQR 350
PTPSGKRVSL SLVANPSHLE AEDPVVLGKV RAIQHYTSDE ASHEQSMGIL 400
IHGDAAFAAQ GVVYETFGLH ALPGYSTGGT VHIVINNQIG FTTDPRFARS 450
TPYCTDIAKS MEAPIFHVNG DDVEAVTFIC QLAADWRKAF KTDVVVDIVC 500
YRRHGHNETD QPSFTQPRMY KAIAKHPPTF KIYTQQLLQE KTVSKAEVDA 550
QEKRVWDILE SSFESSKNYK SDHREWLSNP WVGFASPKDL MTKILPSYPT 600
GVNIDTLKQI GKALYTLPEG FDAHRNLKRI LNNRNKSISS GEGIDMPTAE 650
ALAFGTLLEE GHHVRVSGQD VERGTFSQRH AVLHDQSSEN VYIPLNHLSP 700
NQASFVIRNS SLSEYGVLGF EYGYSLSSPN ALVVWEAQFG DFANNAQCII 750
DQFIAAGETK WLQRTGIVLS LPHGYDGQGP EHSSARMERY LQLCNEDPRE 800
FPSEEKLQRQ HQDCNIQAIY VTKPSQYFHA LRRNIHRQFR KPLVIFFSKS 850
LLRHPAARST IDEFDEKHGF KLILEEEEHG KSILPPEKIE KLIICSGQVW 900
VALSKAREEN KIDNIAITRV EQLHPFGWKQ MAANISQYPN LKEIIWCQEE 950
PLNAGAWTYM EPRIYTILKH LGRDLPVRYA GRPPSASVAA GNKQQHLAEQ 1000
EQFLNDALL 1009
Length:1,009
Mass (Da):114,164
Last modified:November 1, 1998 - v1
Checksum:i4CB2598CE2B5E6AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA20299.1.
PIRiT40412.
RefSeqiNP_595772.1. NM_001021673.2.

Genome annotation databases

EnsemblFungiiSPBC3H7.03c.1; SPBC3H7.03c.1:pep; SPBC3H7.03c.
GeneIDi2540991.
KEGGispo:SPBC3H7.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA20299.1 .
PIRi T40412.
RefSeqi NP_595772.1. NM_001021673.2.

3D structure databases

ProteinModelPortali O74378.
ModBasei Search...

Protein-protein interaction databases

BioGridi 277507. 2 interactions.
MINTi MINT-4678582.
STRINGi 4896.SPBC3H7.03c-1.

Proteomic databases

MaxQBi O74378.
PaxDbi O74378.
PRIDEi O74378.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC3H7.03c.1 ; SPBC3H7.03c.1:pep ; SPBC3H7.03c .
GeneIDi 2540991.
KEGGi spo:SPBC3H7.03c.

Organism-specific databases

PomBasei SPBC3H7.03c.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
KOi K00164.
OMAi QIDKEAR.
OrthoDBi EOG72G1GM.
PhylomeDBi O74378.

Enzyme and pathway databases

Reactomei REACT_208292. Lysine catabolism.
REACT_213505. Citric acid cycle (TCA cycle).

Miscellaneous databases

NextBioi 20802106.
PROi O74378.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiODO1_SCHPO
AccessioniPrimary (citable) accession number: O74378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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