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Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

kgd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Enzyme regulationi

Catabolite repressed.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-SPO-389661. Glyoxylate metabolism and glycine degradation.
R-SPO-71064. Lysine catabolism.
R-SPO-71403. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:kgd1
ORF Names:SPBC3H7.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3H7.03c.
PomBaseiSPBC3H7.03c. kgd1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000031562940 – 10092-oxoglutarate dehydrogenase, mitochondrialAdd BLAST970

Proteomic databases

MaxQBiO74378.
PRIDEiO74378.

Interactioni

Protein-protein interaction databases

BioGridi277507. 1 interactor.
MINTiMINT-4678582.

Structurei

3D structure databases

ProteinModelPortaliO74378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000259586.
InParanoidiO74378.
KOiK00164.
OMAiIWCQEET.
OrthoDBiEOG092C0B3K.
PhylomeDBiO74378.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR032106. 2-oxogl_dehyd_N.
IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR031717. KGD_C.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF16078. 2-oxogl_dehyd_N. 1 hit.
PF00676. E1_dh. 1 hit.
PF16870. OxoGdeHyase_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFIPSSAK ARALRRSAVT AYRLNRLTCL SSLQQNRTFA TQPTDDFLTG
60 70 80 90 100
GAADYVDEMY DAWKKDPNSV HASWQAYFKN VQERGVSPSK AFQAPPLLDY
110 120 130 140 150
ADSYTALDSS LINGNNYADI DVGIYMKVQL LVRAYQSRGH HLAKLDPLGI
160 170 180 190 200
NVNHNRPSEL TLEHYGFTES DLNRTIHLGP GILPNFREAG RKTMTLREIV
210 220 230 240 250
ETCEKIYCGS FAVEFTHISS RKRSNWILSH LETPTPFRYS HDQKIMIFDR
260 270 280 290 300
LSWADSFERF LFTKFPNDKR FGLEGCEAMV PGMKALIDRS VDEGISNIVI
310 320 330 340 350
GMAHRGRLNL LHNIVRKPAQ AIFSEFRGTQ DPDDEGSGDV KYHLGMNYQR
360 370 380 390 400
PTPSGKRVSL SLVANPSHLE AEDPVVLGKV RAIQHYTSDE ASHEQSMGIL
410 420 430 440 450
IHGDAAFAAQ GVVYETFGLH ALPGYSTGGT VHIVINNQIG FTTDPRFARS
460 470 480 490 500
TPYCTDIAKS MEAPIFHVNG DDVEAVTFIC QLAADWRKAF KTDVVVDIVC
510 520 530 540 550
YRRHGHNETD QPSFTQPRMY KAIAKHPPTF KIYTQQLLQE KTVSKAEVDA
560 570 580 590 600
QEKRVWDILE SSFESSKNYK SDHREWLSNP WVGFASPKDL MTKILPSYPT
610 620 630 640 650
GVNIDTLKQI GKALYTLPEG FDAHRNLKRI LNNRNKSISS GEGIDMPTAE
660 670 680 690 700
ALAFGTLLEE GHHVRVSGQD VERGTFSQRH AVLHDQSSEN VYIPLNHLSP
710 720 730 740 750
NQASFVIRNS SLSEYGVLGF EYGYSLSSPN ALVVWEAQFG DFANNAQCII
760 770 780 790 800
DQFIAAGETK WLQRTGIVLS LPHGYDGQGP EHSSARMERY LQLCNEDPRE
810 820 830 840 850
FPSEEKLQRQ HQDCNIQAIY VTKPSQYFHA LRRNIHRQFR KPLVIFFSKS
860 870 880 890 900
LLRHPAARST IDEFDEKHGF KLILEEEEHG KSILPPEKIE KLIICSGQVW
910 920 930 940 950
VALSKAREEN KIDNIAITRV EQLHPFGWKQ MAANISQYPN LKEIIWCQEE
960 970 980 990 1000
PLNAGAWTYM EPRIYTILKH LGRDLPVRYA GRPPSASVAA GNKQQHLAEQ

EQFLNDALL
Length:1,009
Mass (Da):114,164
Last modified:November 1, 1998 - v1
Checksum:i4CB2598CE2B5E6AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20299.1.
PIRiT40412.
RefSeqiNP_595772.1. NM_001021673.2.

Genome annotation databases

EnsemblFungiiSPBC3H7.03c.1; SPBC3H7.03c.1:pep; SPBC3H7.03c.
GeneIDi2540991.
KEGGispo:SPBC3H7.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20299.1.
PIRiT40412.
RefSeqiNP_595772.1. NM_001021673.2.

3D structure databases

ProteinModelPortaliO74378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277507. 1 interactor.
MINTiMINT-4678582.

Proteomic databases

MaxQBiO74378.
PRIDEiO74378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC3H7.03c.1; SPBC3H7.03c.1:pep; SPBC3H7.03c.
GeneIDi2540991.
KEGGispo:SPBC3H7.03c.

Organism-specific databases

EuPathDBiFungiDB:SPBC3H7.03c.
PomBaseiSPBC3H7.03c. kgd1.

Phylogenomic databases

HOGENOMiHOG000259586.
InParanoidiO74378.
KOiK00164.
OMAiIWCQEET.
OrthoDBiEOG092C0B3K.
PhylomeDBiO74378.

Enzyme and pathway databases

ReactomeiR-SPO-389661. Glyoxylate metabolism and glycine degradation.
R-SPO-71064. Lysine catabolism.
R-SPO-71403. Citric acid cycle (TCA cycle).

Miscellaneous databases

PROiO74378.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR032106. 2-oxogl_dehyd_N.
IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR031717. KGD_C.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF16078. 2-oxogl_dehyd_N. 1 hit.
PF00676. E1_dh. 1 hit.
PF16870. OxoGdeHyase_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiODO1_SCHPO
AccessioniPrimary (citable) accession number: O74378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.