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O74378

- ODO1_SCHPO

UniProt

O74378 - ODO1_SCHPO

Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

kgd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    Enzyme regulationi

    Catabolite repressed.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: PomBase
    2. tricarboxylic acid cycle Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    ReactomeiREACT_208292. Lysine catabolism.
    REACT_213505. Citric acid cycle (TCA cycle).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    2-oxoglutarate dehydrogenase complex component E1
    Short name:
    OGDC-E1
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:kgd1
    ORF Names:SPBC3H7.03c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC3H7.03c.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial nucleoid Source: PomBase
    2. mitochondrial oxoglutarate dehydrogenase complex Source: PomBase
    3. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 10099702-oxoglutarate dehydrogenase, mitochondrialPRO_0000315629Add
    BLAST

    Proteomic databases

    MaxQBiO74378.
    PaxDbiO74378.
    PRIDEiO74378.

    Interactioni

    Protein-protein interaction databases

    BioGridi277507. 2 interactions.
    MINTiMINT-4678582.
    STRINGi4896.SPBC3H7.03c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO74378.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259586.
    KOiK00164.
    OMAiQIDKEAR.
    OrthoDBiEOG72G1GM.
    PhylomeDBiO74378.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O74378-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRFIPSSAK ARALRRSAVT AYRLNRLTCL SSLQQNRTFA TQPTDDFLTG     50
    GAADYVDEMY DAWKKDPNSV HASWQAYFKN VQERGVSPSK AFQAPPLLDY 100
    ADSYTALDSS LINGNNYADI DVGIYMKVQL LVRAYQSRGH HLAKLDPLGI 150
    NVNHNRPSEL TLEHYGFTES DLNRTIHLGP GILPNFREAG RKTMTLREIV 200
    ETCEKIYCGS FAVEFTHISS RKRSNWILSH LETPTPFRYS HDQKIMIFDR 250
    LSWADSFERF LFTKFPNDKR FGLEGCEAMV PGMKALIDRS VDEGISNIVI 300
    GMAHRGRLNL LHNIVRKPAQ AIFSEFRGTQ DPDDEGSGDV KYHLGMNYQR 350
    PTPSGKRVSL SLVANPSHLE AEDPVVLGKV RAIQHYTSDE ASHEQSMGIL 400
    IHGDAAFAAQ GVVYETFGLH ALPGYSTGGT VHIVINNQIG FTTDPRFARS 450
    TPYCTDIAKS MEAPIFHVNG DDVEAVTFIC QLAADWRKAF KTDVVVDIVC 500
    YRRHGHNETD QPSFTQPRMY KAIAKHPPTF KIYTQQLLQE KTVSKAEVDA 550
    QEKRVWDILE SSFESSKNYK SDHREWLSNP WVGFASPKDL MTKILPSYPT 600
    GVNIDTLKQI GKALYTLPEG FDAHRNLKRI LNNRNKSISS GEGIDMPTAE 650
    ALAFGTLLEE GHHVRVSGQD VERGTFSQRH AVLHDQSSEN VYIPLNHLSP 700
    NQASFVIRNS SLSEYGVLGF EYGYSLSSPN ALVVWEAQFG DFANNAQCII 750
    DQFIAAGETK WLQRTGIVLS LPHGYDGQGP EHSSARMERY LQLCNEDPRE 800
    FPSEEKLQRQ HQDCNIQAIY VTKPSQYFHA LRRNIHRQFR KPLVIFFSKS 850
    LLRHPAARST IDEFDEKHGF KLILEEEEHG KSILPPEKIE KLIICSGQVW 900
    VALSKAREEN KIDNIAITRV EQLHPFGWKQ MAANISQYPN LKEIIWCQEE 950
    PLNAGAWTYM EPRIYTILKH LGRDLPVRYA GRPPSASVAA GNKQQHLAEQ 1000
    EQFLNDALL 1009
    Length:1,009
    Mass (Da):114,164
    Last modified:November 1, 1998 - v1
    Checksum:i4CB2598CE2B5E6AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA20299.1.
    PIRiT40412.
    RefSeqiNP_595772.1. NM_001021673.2.

    Genome annotation databases

    EnsemblFungiiSPBC3H7.03c.1; SPBC3H7.03c.1:pep; SPBC3H7.03c.
    GeneIDi2540991.
    KEGGispo:SPBC3H7.03c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA20299.1 .
    PIRi T40412.
    RefSeqi NP_595772.1. NM_001021673.2.

    3D structure databases

    ProteinModelPortali O74378.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277507. 2 interactions.
    MINTi MINT-4678582.
    STRINGi 4896.SPBC3H7.03c-1.

    Proteomic databases

    MaxQBi O74378.
    PaxDbi O74378.
    PRIDEi O74378.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC3H7.03c.1 ; SPBC3H7.03c.1:pep ; SPBC3H7.03c .
    GeneIDi 2540991.
    KEGGi spo:SPBC3H7.03c.

    Organism-specific databases

    PomBasei SPBC3H7.03c.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259586.
    KOi K00164.
    OMAi QIDKEAR.
    OrthoDBi EOG72G1GM.
    PhylomeDBi O74378.

    Enzyme and pathway databases

    Reactomei REACT_208292. Lysine catabolism.
    REACT_213505. Citric acid cycle (TCA cycle).

    Miscellaneous databases

    NextBioi 20802106.
    PROi O74378.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiODO1_SCHPO
    AccessioniPrimary (citable) accession number: O74378
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3