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Protein

Protein hob1

Gene

hob1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in DNA damage signaling as a part of stress response processes.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: PomBase
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at telomere Source: PomBase
  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hob1
Alternative name(s):
Homolog of Bin1
Gene namesi
Name:hob1
ORF Names:SPBC21D10.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC21D10.12.
PomBaseiSPBC21D10.12. hob1.

Subcellular locationi

GO - Cellular componenti

  • cell cortex of cell tip Source: PomBase
  • chromosome, centromeric region Source: GOC
  • chromosome, telomeric region Source: GOC
  • medial cortex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Protein hob1PRO_0000192954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei298 – 2981Phosphoserine1 Publication
Modified residuei299 – 2991Phosphoserine1 Publication
Modified residuei301 – 3011Phosphoserine1 Publication
Modified residuei303 – 3031Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74352.

PTM databases

iPTMnetiO74352.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277159. 11 interactions.
MINTiMINT-4678405.

Structurei

3D structure databases

ProteinModelPortaliO74352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 269253BARPROSITE-ProRule annotationAdd
BLAST
Domaini407 – 46660SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili31 – 6737Sequence analysisAdd
BLAST
Coiled coili177 – 20428Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 409116Ala/Pro/Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

HOGENOMiHOG000199510.
InParanoidiO74352.
KOiK12562.
OMAiQEYDYYN.
OrthoDBiEOG7CRV0F.
PhylomeDBiO74352.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWKGFTKAL ARTPQTLRSK FNVGEITKDP IYEDAGRRFK SLETEAKKLA
60 70 80 90 100
EDAKKYTDAI NGLLNHQIGF ADACIEIYKP ISGRASDPES YEQEGNAEGI
110 120 130 140 150
EAAEAYKEIV YDLQKNLASE MDVINTRIVN PTGELLKIVK DVDKLLLKRD
160 170 180 190 200
HKQLDYDRHR SSFKKLQEKK DKSLKDEKKL YEAETAFEQS SQEYEYYNEM
210 220 230 240 250
LKEELPKLFA LAQSFIAPLF QGFYYMQLNV YYVLYEKMSH CEIQYFDFNT
260 270 280 290 300
DILESYERRR GDVKDRAEAL TITKFKTAKP TYKRPGMGPG GKDATASSSS
310 320 330 340 350
SFSSKREEAA AEPSSSTATD IPPPYSTPSV AGASDYSTPS AGYQTVQTTT
360 370 380 390 400
TTTEAAAAQY PQAAFPPPPV MPQPAAAAVT TPVAAPVAAA AAAVPVPPPA
410 420 430 440 450
PAPAAAPAAE HVVALYDYAA QAAGDLSFHA GDRIEVVSRT DNQNEWWIGR
460
LNGAQGQFPG NYVQLE
Length:466
Mass (Da):51,392
Last modified:November 1, 1998 - v1
Checksum:i441793950D6C2C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275637 mRNA. Translation: AAF86458.1.
CU329671 Genomic DNA. Translation: CAA20768.1.
PIRiT11684.
RefSeqiNP_596001.1. NM_001021909.2.

Genome annotation databases

EnsemblFungiiSPBC21D10.12.1; SPBC21D10.12.1:pep; SPBC21D10.12.
GeneIDi2540633.
KEGGispo:SPBC21D10.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275637 mRNA. Translation: AAF86458.1.
CU329671 Genomic DNA. Translation: CAA20768.1.
PIRiT11684.
RefSeqiNP_596001.1. NM_001021909.2.

3D structure databases

ProteinModelPortaliO74352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277159. 11 interactions.
MINTiMINT-4678405.

PTM databases

iPTMnetiO74352.

Proteomic databases

MaxQBiO74352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC21D10.12.1; SPBC21D10.12.1:pep; SPBC21D10.12.
GeneIDi2540633.
KEGGispo:SPBC21D10.12.

Organism-specific databases

EuPathDBiFungiDB:SPBC21D10.12.
PomBaseiSPBC21D10.12. hob1.

Phylogenomic databases

HOGENOMiHOG000199510.
InParanoidiO74352.
KOiK12562.
OMAiQEYDYYN.
OrthoDBiEOG7CRV0F.
PhylomeDBiO74352.

Miscellaneous databases

NextBioi20801758.
PROiO74352.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "hob1+, the fission yeast homolog of Bin1, is dispensable for endocytosis or actin organization, but required for the response to starvation or genotoxic stress."
    Routhier E.L., Donover P.S., Prendergast G.C.
    Oncogene 22:637-648(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; SER-299; SER-301 AND SER-303, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiHOB1_SCHPO
AccessioniPrimary (citable) accession number: O74352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 1, 1998
Last modified: February 17, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.