Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bromodomain-containing protein 1

Gene

bdc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

DNA damage, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain-containing protein 1
Gene namesi
Name:bdc1
ORF Names:SPBC21D10.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC21D10.10.
PomBaseiSPBC21D10.10. bdc1.

Subcellular locationi

GO - Cellular componenti

  • NuA4 histone acetyltransferase complex Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Bromodomain-containing protein 1PRO_0000310329Add
BLAST

Proteomic databases

MaxQBiO74350.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.1 Publication

Protein-protein interaction databases

BioGridi277211. 231 interactions.
IntActiO74350. 1 interaction.
MINTiMINT-8210870.

Structurei

3D structure databases

ProteinModelPortaliO74350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 27271BromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

InParanoidiO74350.
OrthoDBiEOG092C28UX.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
PROSITEiPS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIAQEVAVL QYLDIQQENP NAPNEELFNR TAESSLLLEP IEQDQLKDLV
60 70 80 90 100
EEWMHDSNKS DSKLLSNQVS QNDNDARKNL RKRLRNDVLK DLAEEIQGCE
110 120 130 140 150
KKLESLYEEV AKAKAKAVED QLALEEADKE AKKAKTEAPV EAANKSLRSR
160 170 180 190 200
KKTPEIAAPA NIEPEVAPTT KTPKKRAALS NEEKQSLKKF QSAMLPMLDN
210 220 230 240 250
ISNHRFGAPF SHPVNRKEAP DYDSLVYKPQ DLRTLKNMIK EGNITEVDEL
260 270 280 290
YREVLRIFAN CKMYNGSDPA NAMSIWGDEC FRYTEELFDI YRQASTRSQ
Length:299
Mass (Da):34,145
Last modified:November 1, 1998 - v1
Checksum:i3B489813B039B461
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20766.1.
PIRiT11682.
RefSeqiNP_596003.1. NM_001021911.2.

Genome annotation databases

EnsemblFungiiSPBC21D10.10.1; SPBC21D10.10.1:pep; SPBC21D10.10.
GeneIDi2540686.
KEGGispo:SPBC21D10.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20766.1.
PIRiT11682.
RefSeqiNP_596003.1. NM_001021911.2.

3D structure databases

ProteinModelPortaliO74350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277211. 231 interactions.
IntActiO74350. 1 interaction.
MINTiMINT-8210870.

Proteomic databases

MaxQBiO74350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC21D10.10.1; SPBC21D10.10.1:pep; SPBC21D10.10.
GeneIDi2540686.
KEGGispo:SPBC21D10.10.

Organism-specific databases

EuPathDBiFungiDB:SPBC21D10.10.
PomBaseiSPBC21D10.10. bdc1.

Phylogenomic databases

InParanoidiO74350.
OrthoDBiEOG092C28UX.

Miscellaneous databases

PROiO74350.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
PROSITEiPS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBDC1_SCHPO
AccessioniPrimary (citable) accession number: O74350
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.