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Protein

T-complex protein 1 subunit gamma

Gene

cct3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit gamma
Short name:
TCP-1-gamma
Alternative name(s):
CCT-gamma
Gene namesi
Name:cct3
ORF Names:SPBC1A4.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1A4.08c
PomBaseiSPBC1A4.08c cct3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283301 – 528T-complex protein 1 subunit gammaAdd BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei250Phosphoserine1 Publication1
Disulfide bondi364 ↔ 370By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiO74341
PaxDbiO74341
PRIDEiO74341

PTM databases

iPTMnetiO74341

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277094, 4 interactors
IntActiO74341, 1 interactor
STRINGi4896.SPBC1A4.08c.1

Structurei

3D structure databases

ProteinModelPortaliO74341
SMRiO74341
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

HOGENOMiHOG000226732
InParanoidiO74341
KOiK09495
OMAiDAMCVAR
OrthoDBiEOG092C1WYZ
PhylomeDBiO74341

Family and domain databases

CDDicd03337 TCP1_gamma, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012719 Chap_CCT_gamma
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02344 chap_CCT_gamma, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

O74341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPVFVMNT NGNRQVGHKA QMSNIQAAKA VADVIRTCLG PRAMLKMLLD
60 70 80 90 100
PVGSVLLTND GHAILREIEV AHPAAKSMIE LARTQDEEVG DGTTSVIILA
110 120 130 140 150
GEILAAASPL LDRKIHPVVM IRSFKQALED ALSIIDEITL PVNVDDNAEM
160 170 180 190 200
FRLIRTCIGT KLVARWSDLM CHLALRAVRT VASTSNGRME IDIKRYARVE
210 220 230 240 250
KVPGGEIESS CVLDGVMLNK DVTHPKMRRR IENPRIVLLD CPLEYRKGES
260 270 280 290 300
QTNIEISKDT DWNRILEIEE EQVKRMCDYI IAVKPDLVIT EKGVSDLAQH
310 320 330 340 350
YLLKANITAL RRTRKSDNNR IARACGANIV NRLEDLREKD VGTGCGLFYI
360 370 380 390 400
DKLGDEYYTF LTGCKNPKAC TILLRGPSKD IINEVERNLQ DAMAVARNVF
410 420 430 440 450
FHPKLSPGGG ATEMAVSVRL AEKARSIEGV AQWPYRAVAD AIEIIPRTLV
460 470 480 490 500
QNCGANPIKA LTELRAKHAE GQHSFGIDGE TGRVVDMHEY GVWEPEAVKL
510 520
QSIKTAIESA CLLLRVDDIV SGVRKHSE
Length:528
Mass (Da):58,481
Last modified:November 1, 1998 - v1
Checksum:i260BC1A6DA295E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA20112.1
PIRiT39856
RefSeqiNP_595810.1, NM_001021713.2

Genome annotation databases

EnsemblFungiiSPBC1A4.08c.1; SPBC1A4.08c.1:pep; SPBC1A4.08c
GeneIDi2540567
KEGGispo:SPBC1A4.08c

Similar proteinsi

Entry informationi

Entry nameiTCPG_SCHPO
AccessioniPrimary (citable) accession number: O74341
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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