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Protein

Protein sof1

Gene

sof1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for ribosomal RNA processing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sof1
Alternative name(s):
U3 small nucleolar RNA-associated protein sof1
Short name:
U3 snoRNA-associated protein sof1
Gene namesi
Name:sof1
ORF Names:SPBC1A4.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1A4.07c.
PomBaseiSPBC1A4.07c. sof1.

Subcellular locationi

GO - Cellular componenti

  • Cul4-RING E3 ubiquitin ligase complex Source: GO_Central
  • cytoplasm Source: UniProtKB-KW
  • mitotic spindle Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
  • small-subunit processome Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165451 – 436Protein sof1Add BLAST436

Proteomic databases

MaxQBiO74340.
PRIDEiO74340.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi277315. 4 interactors.
MINTiMINT-4678329.

Structurei

3D structure databases

ProteinModelPortaliO74340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 102WD 1Add BLAST41
Repeati105 – 143WD 2Add BLAST39
Repeati145 – 175WD 3Add BLAST31
Repeati176 – 225WD 4Add BLAST50
Repeati227 – 267WD 5Add BLAST41
Repeati271 – 310WD 6Add BLAST40
Repeati314 – 353WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat DCAF13/WDSOF1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000210082.
InParanoidiO74340.
KOiK11806.
OMAiIQRVPRN.
OrthoDBiEOG092C20W2.
PhylomeDBiO74340.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR007287. Sof1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04158. Sof1. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKTITRGT SLTRLNDQDP VKRNLDPSLH PFERAREYTR ALNATKMDRM
60 70 80 90 100
FAAPFLGQLG RGHQDGVYSL ARDTKTLIDC ASGSGDGAVK LWDASERCER
110 120 130 140 150
WTSKAHEGIV RGLVFSNQGD VLSCASDRYV YMLNKQDGKV KRSYLGDSSL
160 170 180 190 200
LDIDTSKGGD LFATSGENVS IWDYSRDTPV TKFEWGADTL PVVKFNYTET
210 220 230 240 250
SVLASAGMDR SIVIYDLRTS SPLTKLITKL RTNSISWNPM EAFNFVAGSE
260 270 280 290 300
DHNLYMYDMR NLKRALHVYK DHVSAVMSVD FSPTGQEFVS GSYDKTIRIY
310 320 330 340 350
NVREGHSRDV YHTKRMQRVT AVKFSMDAQY IFSGSDDSNV RLWRARASSR
360 370 380 390 400
ASIRSTREEN RLKYLDSLRE RYKHIPEIRR IARHRHLPTN VKKAAEIKRE
410 420 430
EINSLKRREE NIRRHSKKGA VPYEKERERH VVGIQK
Length:436
Mass (Da):49,995
Last modified:November 1, 1998 - v1
Checksum:i4846F514D2863510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20111.1.
PIRiT39855.
RefSeqiNP_595809.1. NM_001021712.2.

Genome annotation databases

EnsemblFungiiSPBC1A4.07c.1; SPBC1A4.07c.1:pep; SPBC1A4.07c.
GeneIDi2540796.
KEGGispo:SPBC1A4.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20111.1.
PIRiT39855.
RefSeqiNP_595809.1. NM_001021712.2.

3D structure databases

ProteinModelPortaliO74340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277315. 4 interactors.
MINTiMINT-4678329.

Proteomic databases

MaxQBiO74340.
PRIDEiO74340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1A4.07c.1; SPBC1A4.07c.1:pep; SPBC1A4.07c.
GeneIDi2540796.
KEGGispo:SPBC1A4.07c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1A4.07c.
PomBaseiSPBC1A4.07c. sof1.

Phylogenomic databases

HOGENOMiHOG000210082.
InParanoidiO74340.
KOiK11806.
OMAiIQRVPRN.
OrthoDBiEOG092C20W2.
PhylomeDBiO74340.

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiO74340.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR007287. Sof1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04158. Sof1. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCA13_SCHPO
AccessioniPrimary (citable) accession number: O74340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.