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O74327

- AVT5_SCHPO

UniProt

O74327 - AVT5_SCHPO

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Protein

Vacuolar amino acid transporter 5

Gene

avt5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation.2 Publications

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: PomBase
  2. L-arginine transmembrane transporter activity Source: PomBase
  3. L-glutamate transmembrane transporter activity Source: PomBase
  4. L-histidine transmembrane transporter activity Source: PomBase
  5. L-lysine transmembrane transporter activity Source: PomBase
  6. L-serine transmembrane transporter activity Source: PomBase
  7. L-tyrosine transmembrane transporter activity Source: PomBase

GO - Biological processi

  1. amino acid transmembrane import into vacuole Source: PomBase
  2. cellular response to nitrogen starvation Source: PomBase
  3. L-arginine transmembrane import into vacuole Source: PomBase
  4. L-glutamate import involved in cellular response to nitrogen starvation Source: PomBase
  5. L-glutamate transmembrane import into vacuole Source: PomBase
  6. L-histidine transmembrane import into vacuole Source: PomBase
  7. lithium ion import Source: PomBase
  8. L-lysine import involved in cellular response to nitrogen starvation Source: PomBase
  9. L-lysine transmembrane import into vacuole Source: PomBase
  10. L-serine transmembrane import into vacuole Source: PomBase
  11. L-tyrosine transmembrane import into vacuole Source: PomBase
  12. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Sporulation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 5
Gene namesi
Name:avt5
Synonyms:avt8
ORF Names:SPBC1685.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC1685.07c.

Subcellular locationi

Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 499VacuolarSequence Analysis
Transmembranei50 – 7021HelicalSequence AnalysisAdd
BLAST
Topological domaini71 – 9626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Topological domaini118 – 14124VacuolarSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 1664CytoplasmicSequence Analysis
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Topological domaini188 – 1958VacuolarSequence Analysis
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Topological domaini217 – 24024CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Topological domaini262 – 27817VacuolarSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Topological domaini300 – 32627CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence AnalysisAdd
BLAST
Topological domaini348 – 3492VacuolarSequence Analysis
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Topological domaini371 – 39424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST
Topological domaini416 – 4205VacuolarSequence Analysis

GO - Cellular componenti

  1. fungal-type vacuole membrane Source: PomBase
  2. integral component of fungal-type vacuolar membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Vacuolar amino acid transporter 5PRO_0000316193Add
BLAST

Proteomic databases

MaxQBiO74327.

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBC1685.07c-1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
HOGENOMiHOG000173527.
InParanoidiO74327.
OMAiCLNINIA.
OrthoDBiEOG7C8GSX.
PhylomeDBiO74327.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74327-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGYSPLSSG PADVHIGKAG FFSSVINLAN TILGAGILSL PNAFTKTGLL
60 70 80 90 100
FGCLTIVFSA FASFLGLYFV SQCAARLPRG KASFAAVAKH TFPSLAVVFD
110 120 130 140 150
ASIAVKCFGV AVSYLVIVGD LMPQIAPSLG LSSPMFLRRQ TWIVFALFVL
160 170 180 190 200
TPLSFLKRLD SLRHTSVISL IALCYLVFIV LYHFIIGDTV KGEIRYFVPE
210 220 230 240 250
SGFGYLSVLP VFVFGFTCHQ NAFSVINEVR NFSQGFVNFT MFTAIISSTL
260 270 280 290 300
LYLLVAITGY LSFGSLASGN IIAMYDNTSI WIIGGKLAIV VLVLFSYPLQ
310 320 330 340 350
CHPCRNSVYQ AIRRSYSAHD MSDGYHAVIT LCILLFTHSL ALLLSSLEMV
360 370 380 390 400
LAFVGSTGST FISFILPGSL YYFFSHKVAS PGNSSPLQLR ISRAFAAGLA
410 420
IYGTVVMILC LNINIAKLSH
Length:420
Mass (Da):45,462
Last modified:November 1, 1998 - v1
Checksum:iD76B8834CE66E170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20055.1.
PIRiT39523.
RefSeqiNP_595211.1. NM_001021118.2.

Genome annotation databases

EnsemblFungiiSPBC1685.07c.1; SPBC1685.07c.1:pep; SPBC1685.07c.
GeneIDi2540081.
KEGGispo:SPBC1685.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20055.1 .
PIRi T39523.
RefSeqi NP_595211.1. NM_001021118.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4896.SPBC1685.07c-1.

Proteomic databases

MaxQBi O74327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC1685.07c.1 ; SPBC1685.07c.1:pep ; SPBC1685.07c .
GeneIDi 2540081.
KEGGi spo:SPBC1685.07c.

Organism-specific databases

PomBasei SPBC1685.07c.

Phylogenomic databases

eggNOGi COG0814.
HOGENOMi HOG000173527.
InParanoidi O74327.
OMAi CLNINIA.
OrthoDBi EOG7C8GSX.
PhylomeDBi O74327.

Miscellaneous databases

NextBioi 20801218.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation."
    Mukaiyama H., Kajiwara S., Hosomi A., Giga-Hama Y., Tanaka N., Nakamura T., Takegawa K.
    Microbiology 155:3816-3826(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Avt5p is required for vacuolar uptake of amino acids in the fission yeast Schizosaccharomyces pombe."
    Chardwiriyapreecha S., Mukaiyama H., Sekito T., Iwaki T., Takegawa K., Kakinuma Y.
    FEBS Lett. 584:2339-2345(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAVT5_SCHPO
AccessioniPrimary (citable) accession number: O74327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3