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Protein

Vacuolar amino acid transporter 5

Gene

avt5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation.2 Publications

GO - Molecular functioni

  • arginine transmembrane transporter activity Source: PomBase
  • L-arginine transmembrane transporter activity Source: PomBase
  • L-glutamate transmembrane transporter activity Source: PomBase
  • L-histidine transmembrane transporter activity Source: PomBase
  • L-lysine transmembrane transporter activity Source: PomBase
  • L-serine transmembrane transporter activity Source: PomBase
  • L-tyrosine transmembrane transporter activity Source: PomBase

GO - Biological processi

  • amino acid transmembrane import into vacuole Source: PomBase
  • L-arginine transmembrane import into vacuole Source: PomBase
  • L-glutamate import involved in cellular response to nitrogen starvation Source: PomBase
  • L-glutamate transmembrane import into vacuole Source: PomBase
  • L-histidine transmembrane import into vacuole Source: PomBase
  • lithium ion import Source: PomBase
  • L-lysine import involved in cellular response to nitrogen starvation Source: PomBase
  • L-lysine transmembrane import into vacuole Source: PomBase
  • L-serine transmembrane import into vacuole Source: PomBase
  • L-tyrosine transmembrane import into vacuole Source: PomBase
  • sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Sporulation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 5
Gene namesi
Name:avt5
Synonyms:avt8
ORF Names:SPBC1685.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1685.07c.
PomBaseiSPBC1685.07c. avt5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 49VacuolarSequence analysis9
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 96CytoplasmicSequence analysisAdd BLAST26
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 141VacuolarSequence analysisAdd BLAST24
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 166CytoplasmicSequence analysis4
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 195VacuolarSequence analysis8
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 240CytoplasmicSequence analysisAdd BLAST24
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 278VacuolarSequence analysisAdd BLAST17
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 326CytoplasmicSequence analysisAdd BLAST27
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 349VacuolarSequence analysis2
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 394CytoplasmicSequence analysisAdd BLAST24
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 420VacuolarSequence analysis5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003161931 – 420Vacuolar amino acid transporter 5Add BLAST420

Proteomic databases

MaxQBiO74327.
PRIDEiO74327.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000173527.
InParanoidiO74327.
OMAiCLNINIA.
OrthoDBiEOG092C2GRV.
PhylomeDBiO74327.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYSPLSSG PADVHIGKAG FFSSVINLAN TILGAGILSL PNAFTKTGLL
60 70 80 90 100
FGCLTIVFSA FASFLGLYFV SQCAARLPRG KASFAAVAKH TFPSLAVVFD
110 120 130 140 150
ASIAVKCFGV AVSYLVIVGD LMPQIAPSLG LSSPMFLRRQ TWIVFALFVL
160 170 180 190 200
TPLSFLKRLD SLRHTSVISL IALCYLVFIV LYHFIIGDTV KGEIRYFVPE
210 220 230 240 250
SGFGYLSVLP VFVFGFTCHQ NAFSVINEVR NFSQGFVNFT MFTAIISSTL
260 270 280 290 300
LYLLVAITGY LSFGSLASGN IIAMYDNTSI WIIGGKLAIV VLVLFSYPLQ
310 320 330 340 350
CHPCRNSVYQ AIRRSYSAHD MSDGYHAVIT LCILLFTHSL ALLLSSLEMV
360 370 380 390 400
LAFVGSTGST FISFILPGSL YYFFSHKVAS PGNSSPLQLR ISRAFAAGLA
410 420
IYGTVVMILC LNINIAKLSH
Length:420
Mass (Da):45,462
Last modified:November 1, 1998 - v1
Checksum:iD76B8834CE66E170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20055.1.
PIRiT39523.
RefSeqiNP_595211.1. NM_001021118.2.

Genome annotation databases

EnsemblFungiiSPBC1685.07c.1; SPBC1685.07c.1:pep; SPBC1685.07c.
GeneIDi2540081.
KEGGispo:SPBC1685.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20055.1.
PIRiT39523.
RefSeqiNP_595211.1. NM_001021118.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiO74327.
PRIDEiO74327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1685.07c.1; SPBC1685.07c.1:pep; SPBC1685.07c.
GeneIDi2540081.
KEGGispo:SPBC1685.07c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1685.07c.
PomBaseiSPBC1685.07c. avt5.

Phylogenomic databases

HOGENOMiHOG000173527.
InParanoidiO74327.
OMAiCLNINIA.
OrthoDBiEOG092C2GRV.
PhylomeDBiO74327.

Miscellaneous databases

PROiO74327.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAVT5_SCHPO
AccessioniPrimary (citable) accession number: O74327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.