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O74327

- AVT5_SCHPO

UniProt

O74327 - AVT5_SCHPO

Protein

Vacuolar amino acid transporter 5

Gene

avt5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation.2 Publications

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: PomBase
    2. L-arginine transmembrane transporter activity Source: PomBase
    3. L-glutamate transmembrane transporter activity Source: PomBase
    4. L-histidine transmembrane transporter activity Source: PomBase
    5. L-lysine transmembrane transporter activity Source: PomBase
    6. L-serine transmembrane transporter activity Source: PomBase
    7. L-tyrosine transmembrane transporter activity Source: PomBase

    GO - Biological processi

    1. amino acid transmembrane import into vacuole Source: PomBase
    2. cellular response to nitrogen starvation Source: PomBase
    3. L-arginine transmembrane import into vacuole Source: PomBase
    4. L-glutamate import involved in cellular response to nitrogen starvation Source: PomBase
    5. L-glutamate transmembrane import into vacuole Source: PomBase
    6. L-histidine transmembrane import into vacuole Source: PomBase
    7. lithium ion import Source: PomBase
    8. L-lysine import involved in cellular response to nitrogen starvation Source: PomBase
    9. L-lysine transmembrane import into vacuole Source: PomBase
    10. L-serine transmembrane import into vacuole Source: PomBase
    11. L-tyrosine transmembrane import into vacuole Source: PomBase
    12. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Sporulation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar amino acid transporter 5
    Gene namesi
    Name:avt5
    Synonyms:avt8
    ORF Names:SPBC1685.07c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1685.07c.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. fungal-type vacuole membrane Source: PomBase
    2. integral component of fungal-type vacuolar membrane Source: PomBase

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Vacuolar amino acid transporter 5PRO_0000316193Add
    BLAST

    Proteomic databases

    MaxQBiO74327.

    Interactioni

    Protein-protein interaction databases

    STRINGi4896.SPBC1685.07c-1.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 499VacuolarSequence Analysis
    Topological domaini71 – 9626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini118 – 14124VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini163 – 1664CytoplasmicSequence Analysis
    Topological domaini188 – 1958VacuolarSequence Analysis
    Topological domaini217 – 24024CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27817VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini300 – 32627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini348 – 3492VacuolarSequence Analysis
    Topological domaini371 – 39424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini416 – 4205VacuolarSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    HOGENOMiHOG000173527.
    OMAiCLNINIA.
    OrthoDBiEOG7C8GSX.
    PhylomeDBiO74327.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74327-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGYSPLSSG PADVHIGKAG FFSSVINLAN TILGAGILSL PNAFTKTGLL    50
    FGCLTIVFSA FASFLGLYFV SQCAARLPRG KASFAAVAKH TFPSLAVVFD 100
    ASIAVKCFGV AVSYLVIVGD LMPQIAPSLG LSSPMFLRRQ TWIVFALFVL 150
    TPLSFLKRLD SLRHTSVISL IALCYLVFIV LYHFIIGDTV KGEIRYFVPE 200
    SGFGYLSVLP VFVFGFTCHQ NAFSVINEVR NFSQGFVNFT MFTAIISSTL 250
    LYLLVAITGY LSFGSLASGN IIAMYDNTSI WIIGGKLAIV VLVLFSYPLQ 300
    CHPCRNSVYQ AIRRSYSAHD MSDGYHAVIT LCILLFTHSL ALLLSSLEMV 350
    LAFVGSTGST FISFILPGSL YYFFSHKVAS PGNSSPLQLR ISRAFAAGLA 400
    IYGTVVMILC LNINIAKLSH 420
    Length:420
    Mass (Da):45,462
    Last modified:November 1, 1998 - v1
    Checksum:iD76B8834CE66E170
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA20055.1.
    PIRiT39523.
    RefSeqiNP_595211.1. NM_001021118.2.

    Genome annotation databases

    EnsemblFungiiSPBC1685.07c.1; SPBC1685.07c.1:pep; SPBC1685.07c.
    GeneIDi2540081.
    KEGGispo:SPBC1685.07c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA20055.1 .
    PIRi T39523.
    RefSeqi NP_595211.1. NM_001021118.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4896.SPBC1685.07c-1.

    Proteomic databases

    MaxQBi O74327.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1685.07c.1 ; SPBC1685.07c.1:pep ; SPBC1685.07c .
    GeneIDi 2540081.
    KEGGi spo:SPBC1685.07c.

    Organism-specific databases

    PomBasei SPBC1685.07c.

    Phylogenomic databases

    eggNOGi COG0814.
    HOGENOMi HOG000173527.
    OMAi CLNINIA.
    OrthoDBi EOG7C8GSX.
    PhylomeDBi O74327.

    Miscellaneous databases

    NextBioi 20801218.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation."
      Mukaiyama H., Kajiwara S., Hosomi A., Giga-Hama Y., Tanaka N., Nakamura T., Takegawa K.
      Microbiology 155:3816-3826(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Avt5p is required for vacuolar uptake of amino acids in the fission yeast Schizosaccharomyces pombe."
      Chardwiriyapreecha S., Mukaiyama H., Sekito T., Iwaki T., Takegawa K., Kakinuma Y.
      FEBS Lett. 584:2339-2345(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAVT5_SCHPO
    AccessioniPrimary (citable) accession number: O74327
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3