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Protein

Signal peptidase complex catalytic subunit sec11

Gene

sec11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei47By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit sec11 (EC:3.4.21.89)
Gene namesi
Name:sec11
ORF Names:SPBC1685.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1685.03.
PomBaseiSPBC1685.03. sec11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini26 – 189LumenalSequence analysisAdd BLAST164

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
  • signal peptidase complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141151 – 189Signal peptidase complex catalytic subunit sec11Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO74323.
PRIDEiO74323.

Interactioni

Protein-protein interaction databases

BioGridi276209. 1 interactor.
MINTiMINT-4678236.

Structurei

3D structure databases

ProteinModelPortaliO74323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000111516.
InParanoidiO74323.
KOiK13280.
OMAiHREEDIV.
OrthoDBiEOG092C4ZUJ.
PhylomeDBiO74323.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 2 hits.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

O74323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLSFRQGL AQILNLLLVL SSAYMGYKTL SFVTDCESPV VVVLSESMEP
60 70 80 90 100
SFQRGDLLFL DNRNPSFDEA KVPSVFEKII YGSPVGIGDI VVYSLPDRPI
110 120 130 140 150
PIVHRVVKLY ESENQTHLIT KGDNNKIDDV AMFPKSINYL DRENHILGVV
160 170 180
RGYFPYLGMI TIWLTDYPIL KYIMLGGLGL LTLIQKEEQ
Length:189
Mass (Da):21,403
Last modified:November 1, 1998 - v1
Checksum:i9E8EDDB6E6B10071
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20051.1.
PIRiT39519.
RefSeqiNP_595207.1. NM_001021113.2.

Genome annotation databases

EnsemblFungiiSPBC1685.03.1; SPBC1685.03.1:pep; SPBC1685.03.
GeneIDi2539654.
KEGGispo:SPBC1685.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20051.1.
PIRiT39519.
RefSeqiNP_595207.1. NM_001021113.2.

3D structure databases

ProteinModelPortaliO74323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276209. 1 interactor.
MINTiMINT-4678236.

Protein family/group databases

MEROPSiS26.010.

Proteomic databases

MaxQBiO74323.
PRIDEiO74323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1685.03.1; SPBC1685.03.1:pep; SPBC1685.03.
GeneIDi2539654.
KEGGispo:SPBC1685.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC1685.03.
PomBaseiSPBC1685.03. sec11.

Phylogenomic databases

HOGENOMiHOG000111516.
InParanoidiO74323.
KOiK13280.
OMAiHREEDIV.
OrthoDBiEOG092C4ZUJ.
PhylomeDBiO74323.

Miscellaneous databases

PROiO74323.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 2 hits.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSEC11_SCHPO
AccessioniPrimary (citable) accession number: O74323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.