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Protein

Transcription initiation factor TFIID subunit taf73

Gene

taf73

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit taf73
Alternative name(s):
Transcription initiation factor TFIID 73 kDa subunit
Short name:
TAFII-73
Gene namesi
Name:taf73
ORF Names:SPBC15D4.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC15D4.14.
PomBaseiSPBC15D4.14. taf73.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • transcription factor TFIID complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Transcription initiation factor TFIID subunit taf73PRO_0000234562Add
BLAST

Proteomic databases

MaxQBiO74319.

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 25-150 kDa.1 Publication

Protein-protein interaction databases

BioGridi276428. 10 interactions.
IntActiO74319. 4 interactions.
MINTiMINT-4678208.

Structurei

3D structure databases

ProteinModelPortaliO74319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 4333LisHPROSITE-ProRule annotationAdd
BLAST
Repeati347 – 38640WD 1Add
BLAST
Repeati401 – 44040WD 2Add
BLAST
Repeati443 – 48240WD 3Add
BLAST
Repeati485 – 52642WD 4Add
BLAST
Repeati528 – 56639WD 5Add
BLAST
Repeati569 – 60840WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000212424.
InParanoidiO74319.
KOiK03130.
OMAiFESFRIE.
OrthoDBiEOG7KQ29H.
PhylomeDBiO74319.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSSYSSGN STSDLNKIVL DYLFKKGYSR TEAMLRLEIS SVGAIPEEQQ
60 70 80 90 100
DWHIGASETY VQVYILLRDW IDGTLDLYKP KLQKVLYPIF VHSYLDLLQK
110 120 130 140 150
NDPEMAIYFF ESFRIEHEVL HGYDIRALAQ LKIASDVEEI EIAQLYRKNK
160 170 180 190 200
YRINFTRSTF DLLVQFLFEN EVNGSGIIIR LLNQYIDIKI TMPQVEGKED
210 220 230 240 250
PNVQAVYEMD EAKNEQTIIS EQEGIPGHSE QLLDYNKQSI QLGLRPLSEE
260 270 280 290 300
VVTTLKNLLE VKDKDVEGRN EALNKILHPA KNLVELLTEK ENLINESTLE
310 320 330 340 350
SPSDPPLPPT KMKDIDYFVS LLESEQNSLI LGKNATDPSV FMYTMHNTLS
360 370 380 390 400
AVNCAAFSDD ASMFALGCAD SSIHLYSSTN NGPQPLVGSQ NEPLQKSSLI
410 420 430 440 450
GHTRPVFGVS ISPQKEFILS CSEDGFTRLW SKDTKSTIVK YAGHNAPIWD
460 470 480 490 500
VQFSPFGYYF ATASHDQTAR LWDVEHAAPL RVFVGHQNDV DCVSFHPNAA
510 520 530 540 550
YLATGSSDHT TRMWDVRTGG TVRVFNAHHS PVSALCMSAD GLSLASADES
560 570 580 590 600
GIIKVWDLRS SNQHVSFVKH SSIVYSLSFS YDNKILVSGG ADTDVNFWDL
610 620 630 640
TYRNNLSDGE QSPLLFNFKT KNTIIQNLSF TRRNYCLALS SS
Length:642
Mass (Da):72,251
Last modified:November 1, 1998 - v1
Checksum:i6891234235FF6DBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20489.1.
AB039954 Genomic DNA. Translation: BAB12572.1.
PIRiT39490.
RefSeqiNP_596254.1. NM_001022173.2.

Genome annotation databases

EnsemblFungiiSPBC15D4.14.1; SPBC15D4.14.1:pep; SPBC15D4.14.
GeneIDi2539882.
KEGGispo:SPBC15D4.14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20489.1.
AB039954 Genomic DNA. Translation: BAB12572.1.
PIRiT39490.
RefSeqiNP_596254.1. NM_001022173.2.

3D structure databases

ProteinModelPortaliO74319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276428. 10 interactions.
IntActiO74319. 4 interactions.
MINTiMINT-4678208.

Proteomic databases

MaxQBiO74319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC15D4.14.1; SPBC15D4.14.1:pep; SPBC15D4.14.
GeneIDi2539882.
KEGGispo:SPBC15D4.14.

Organism-specific databases

EuPathDBiFungiDB:SPBC15D4.14.
PomBaseiSPBC15D4.14. taf73.

Phylogenomic databases

HOGENOMiHOG000212424.
InParanoidiO74319.
KOiK03130.
OMAiFESFRIE.
OrthoDBiEOG7KQ29H.
PhylomeDBiO74319.

Enzyme and pathway databases

ReactomeiR-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiO74319.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR007582. TFIID_NTD2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_NTD2. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two WD repeat-containing TATA-binding protein-associated factors in fission yeast that suppress defects in the anaphase-promoting complex."
    Mitsuzawa H., Seino H., Yamao F., Ishihama A.
    J. Biol. Chem. 276:17117-17124(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiTAF73_SCHPO
AccessioniPrimary (citable) accession number: O74319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.