O74315 (AMO1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoporin-like protein amo1

Alternative name(s):
Aberrant microtubule protein 1

Gene names

Name:	amo1
ORF Names:	SPBC15D4.10c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the cell polarity process where it is required for the correct termination of microtubule growth at the cell ends during interphase. Ref.2
Subcellular location	Nucleus. Note: Nucleus; nuclear rim. Ref.2
Sequence similarities	Contains 1 C3H1-type zinc finger.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cytoplasmic microtubule organization Inferred from mutant phenotype. Source: GeneDB_Spombe establishment of nucleus localization Inferred from mutant phenotype. Source: GeneDB_Spombe establishment or maintenance of microtubule cytoskeleton polarity Inferred from mutant phenotype. Source: GeneDB_Spombe negative regulation of microtubule polymerization Inferred from mutant phenotype. Source: GeneDB_Spombe
Cellular component	nuclear membrane Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Nucleoporin-like protein amo1		PRO_0000064588
Regions
	Zinc finger	1 – 25	25	C3H1-type
	Compositional bias	213 – 304	92	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	O74315 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: BF8567581869C74C	FASTA	475	51,792
	10 20 30 40 50 60 MVVCKYFLQN RCRYGTNCKN QHTVPSNGQN AFSKVNVFRP ENGRPPIWVQ RRLKRSDLDN 70 80 90 100 110 120 LLPNRRMKDI NDDLKNAKPQ WPFTGYSVVE NLPSIYEGDV SPEELRWWAY QAKATNNMQA 130 140 150 160 170 180 YEQRQKQLMD DVEAKAAAVK RSPAAAFDEM RNKLVGKTNY KSIFDKSTSN STVTSNQFNK 190 200 210 220 230 240 PTQNSPFNSF SNNNNSFNNN QQANDIFGAP TTSAFTSQLN ASPFSQNTSS NSFTGSNPVQ 250 260 270 280 290 300 NNPSSFGSSS FGSATSGPSA FGGISQPNSS FVNSGQGIPN SSFSSFSQVA SGFSQSQNVN 310 320 330 340 350 360 DPSSIFGPTV ASGFGIQNQP QQSAFQNLNT QFSLPNNSQP VFGHTSLTQP VNPNGFTVQP 370 380 390 400 410 420 PATFMQQPQG PFVPPNTTFE SPFANVTSKI SASGFSNDNP ANKNIIQTPM FGSSNTIDGP 430 440 450 460 470 INPIGASSIQ TLDDQVEMSN SNQNLAFPPE MIQQFEAQDF IPGKVPTTAP PPQFC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast." Pardo M., Nurse P. J. Cell Sci. 118:1705-1714(2005) [PubMed: 15797925] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAA20485.1.
PIR	T39486.
RefSeq	NP_596250.1. NM_001022169.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O74315.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPBC15D4.10c.1; SPBC15D4.10c.1:pep; SPBC15D4.10c.
GeneID	2539911.
GenomeReviews	Gene locus amo1 in contig CU329671_GR.
KEGG	spo:SPBC15D4.10c.
NMPDR	fig|4896.1.peg.2116.
Organism-specific databases
GeneDB_Spombe	SPBC15D4.10c.
Phylogenomic databases
eggNOG	fuNOG08720.
GeneTree	EFGT00050000000035.
OMA	NAFASFN.
OrthoDB	EOG441TN6.
Gene expression databases
ArrayExpress	O74315.
Family and domain databases
InterPro	IPR000571. Znf_CCCH. [Graphical view]
KO	K14321.
PROSITE	PS50103. ZF_C3H1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMO1_SCHPO

Accession

Primary (citable) accession number: O74315

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	November 1, 1998
Last modified:	November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program