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Protein

Histone transcription regulator slm9

Gene

slm9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably required for replication-independent chromatin assembly (By similarity). Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. May play an indirect role in the regulation of cdc2 and/or wee1 at the G2/M stage of mitosis.By similarity3 Publications

GO - Molecular functioni

  • nucleosome binding Source: GO_Central
  • transcription corepressor activity Source: PomBase

GO - Biological processi

  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • DNA replication-independent nucleosome assembly Source: GO_Central
  • heterochromatin organization involved in chromatin silencing Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • regulation of chromatin silencing Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone transcription regulator slm9
Gene namesi
Name:slm9
ORF Names:SPBC15D4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC15D4.03
PomBaseiSPBC15D4.03 slm9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512191 – 807Histone transcription regulator slm9Add BLAST807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei406Phosphoserine1 Publication1
Modified residuei421Phosphoserine1 Publication1
Modified residuei422Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74309
PaxDbiO74309
PRIDEiO74309

PTM databases

iPTMnetiO74309

Interactioni

Subunit structurei

Interacts with hip1 and hip3.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi276665, 74 interactors
IntActiO74309, 2 interactors
STRINGi4896.SPBC15D4.03.1

Structurei

3D structure databases

ProteinModelPortaliO74309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 100WD 1Add BLAST39
Repeati102 – 140WD 2Add BLAST39
Repeati182 – 221WD 3Add BLAST40
Repeati230 – 273WD 4Add BLAST44
Repeati276 – 322WD 5Add BLAST47
Repeati326 – 367WD 6Add BLAST42
Repeati492 – 526WD 7Add BLAST35
Repeati528 – 574WD 8Add BLAST47

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO74309
KOiK11293
OMAiRICELGI
OrthoDBiEOG092C0UNU
PhylomeDBiO74309

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR031120 HIR1
IPR011494 Hira
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13831 PTHR13831, 2 hits
PfamiView protein in Pfam
PF07569 Hira, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O74309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIFVPKLLE NHQFSSISSS KDFVAVSAET NVYILSKDFF YPKSSEKRII
60 70 80 90 100
QSLNGHKTTH LSFDSPISCI RFTYDGSCLA VATEAGTFLY HSEKWDKAFQ
110 120 130 140 150
VLSGPAYEVC WSQQGHILAT SWKQISIYVK DEGLRTETIV KKTEHADSNH
160 170 180 190 200
QPAVSIEESK EAVESTSQSS EISFKLIKVI EGHHTFVGGL AFDPMGQFLA
210 220 230 240 250
SQSFDHTLKV WKLSTFGVEK SIAKPFEQMP TGNRFLRLSW SPDGAHIASV
260 270 280 290 300
NAVNEGAYVI AIVQRDTWTY DINLVGHQGP LECATFNPYL YEDPFQKSII
310 320 330 340 350
ASAAHDGCVS IWNTACARPM AVIHELSCSS FVDLQWSTSG FELYGVSLDG
360 370 380 390 400
NLMLLQFEES EFGEKMDTIH YPDDLSYFNS SRSKAHVNKN AAADRTTSPT
410 420 430 440 450
QGQPESPSKS ILLRPPPSIA SSPESKRRKC PKKFVARPPV PHPTSLYSQI
460 470 480 490 500
RIGCPYLKPK LVISKSFGTL IVKNHNQLSL LKCTFSNLDG NDCSWFSYLP
510 520 530 540 550
NAIVLANGTS VFWAVATEDS SIYIYSPAGR LLLPPVVVAA TPCFLECCGD
560 570 580 590 600
FLCCIVSTGL LYIWNIKNFE AIHSPVSTLP LFHSNFSVSK IARGPSIEQF
610 620 630 640 650
FVTKQGHPVA IMSDGNAFAF IRDSSSWLRV SEGWWMIGSQ YWGPLASESN
660 670 680 690 700
EESPLGFLER CTDEEIIKAG RGRFLQRLVK ALMLRQGYDN YEMLVSIRHL
710 720 730 740 750
ENRLMSSAKL DLEYDFRENL ILYAKKIAEE GMKDKMDELC KELLGPLRIP
760 770 780 790 800
HNGIDTVKVG NRLWSPTIAG NNKRNLLKDI IIHTAKYRDM QRITSQYSDL

LRRSALL
Length:807
Mass (Da):90,433
Last modified:November 1, 1998 - v1
Checksum:iB8BFB73852EB7B45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA20478.1
PIRiT39479
RefSeqiNP_596243.1, NM_001022162.2

Genome annotation databases

EnsemblFungiiSPBC15D4.03.1; SPBC15D4.03.1:pep; SPBC15D4.03
GeneIDi2540128
KEGGispo:SPBC15D4.03

Similar proteinsi

Entry informationi

Entry nameiSLM9_SCHPO
AccessioniPrimary (citable) accession number: O74309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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