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Protein

Histone transcription regulator slm9

Gene

slm9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably required for replication-independent chromatin assembly (By similarity). Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. May play an indirect role in the regulation of cdc2 and/or wee1 at the G2/M stage of mitosis.By similarity3 Publications

GO - Molecular functioni

  • transcription corepressor activity Source: PomBase

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • heterochromatin organization involved in chromatin silencing Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone transcription regulator slm9
Gene namesi
Name:slm9
ORF Names:SPBC15D4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC15D4.03.
PomBaseiSPBC15D4.03. slm9.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: GOC
  • cytosol Source: PomBase
  • HIR complex Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Histone transcription regulator slm9PRO_0000051219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei406 – 4061Phosphoserine1 Publication
Modified residuei421 – 4211Phosphoserine1 Publication
Modified residuei422 – 4221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74309.

PTM databases

iPTMnetiO74309.

Interactioni

Subunit structurei

Interacts with hip1 and hip3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
hip1P873144EBI-1556117,EBI-1556094
hip3P873153EBI-1556117,EBI-1556159

Protein-protein interaction databases

BioGridi276665. 74 interactions.
IntActiO74309. 2 interactions.
MINTiMINT-4678132.

Structurei

3D structure databases

ProteinModelPortaliO74309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 10039WD 1Add
BLAST
Repeati102 – 14039WD 2Add
BLAST
Repeati182 – 22140WD 3Add
BLAST
Repeati230 – 27344WD 4Add
BLAST
Repeati276 – 32247WD 5Add
BLAST
Repeati326 – 36742WD 6Add
BLAST
Repeati492 – 52635WD 7Add
BLAST
Repeati528 – 57447WD 8Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO74309.
KOiK11293.
OMAiRICELGI.
OrthoDBiEOG092C0UNU.
PhylomeDBiO74309.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR031120. HIR1.
IPR011494. Hira.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13831. PTHR13831. 1 hit.
PfamiPF07569. Hira. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIFVPKLLE NHQFSSISSS KDFVAVSAET NVYILSKDFF YPKSSEKRII
60 70 80 90 100
QSLNGHKTTH LSFDSPISCI RFTYDGSCLA VATEAGTFLY HSEKWDKAFQ
110 120 130 140 150
VLSGPAYEVC WSQQGHILAT SWKQISIYVK DEGLRTETIV KKTEHADSNH
160 170 180 190 200
QPAVSIEESK EAVESTSQSS EISFKLIKVI EGHHTFVGGL AFDPMGQFLA
210 220 230 240 250
SQSFDHTLKV WKLSTFGVEK SIAKPFEQMP TGNRFLRLSW SPDGAHIASV
260 270 280 290 300
NAVNEGAYVI AIVQRDTWTY DINLVGHQGP LECATFNPYL YEDPFQKSII
310 320 330 340 350
ASAAHDGCVS IWNTACARPM AVIHELSCSS FVDLQWSTSG FELYGVSLDG
360 370 380 390 400
NLMLLQFEES EFGEKMDTIH YPDDLSYFNS SRSKAHVNKN AAADRTTSPT
410 420 430 440 450
QGQPESPSKS ILLRPPPSIA SSPESKRRKC PKKFVARPPV PHPTSLYSQI
460 470 480 490 500
RIGCPYLKPK LVISKSFGTL IVKNHNQLSL LKCTFSNLDG NDCSWFSYLP
510 520 530 540 550
NAIVLANGTS VFWAVATEDS SIYIYSPAGR LLLPPVVVAA TPCFLECCGD
560 570 580 590 600
FLCCIVSTGL LYIWNIKNFE AIHSPVSTLP LFHSNFSVSK IARGPSIEQF
610 620 630 640 650
FVTKQGHPVA IMSDGNAFAF IRDSSSWLRV SEGWWMIGSQ YWGPLASESN
660 670 680 690 700
EESPLGFLER CTDEEIIKAG RGRFLQRLVK ALMLRQGYDN YEMLVSIRHL
710 720 730 740 750
ENRLMSSAKL DLEYDFRENL ILYAKKIAEE GMKDKMDELC KELLGPLRIP
760 770 780 790 800
HNGIDTVKVG NRLWSPTIAG NNKRNLLKDI IIHTAKYRDM QRITSQYSDL

LRRSALL
Length:807
Mass (Da):90,433
Last modified:November 1, 1998 - v1
Checksum:iB8BFB73852EB7B45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20478.1.
PIRiT39479.
RefSeqiNP_596243.1. NM_001022162.2.

Genome annotation databases

EnsemblFungiiSPBC15D4.03.1; SPBC15D4.03.1:pep; SPBC15D4.03.
GeneIDi2540128.
KEGGispo:SPBC15D4.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20478.1.
PIRiT39479.
RefSeqiNP_596243.1. NM_001022162.2.

3D structure databases

ProteinModelPortaliO74309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276665. 74 interactions.
IntActiO74309. 2 interactions.
MINTiMINT-4678132.

PTM databases

iPTMnetiO74309.

Proteomic databases

MaxQBiO74309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC15D4.03.1; SPBC15D4.03.1:pep; SPBC15D4.03.
GeneIDi2540128.
KEGGispo:SPBC15D4.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC15D4.03.
PomBaseiSPBC15D4.03. slm9.

Phylogenomic databases

InParanoidiO74309.
KOiK11293.
OMAiRICELGI.
OrthoDBiEOG092C0UNU.
PhylomeDBiO74309.

Miscellaneous databases

PROiO74309.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR031120. HIR1.
IPR011494. Hira.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13831. PTHR13831. 1 hit.
PfamiPF07569. Hira. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLM9_SCHPO
AccessioniPrimary (citable) accession number: O74309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.