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O74298

- LYS2_PENCH

UniProt

O74298 - LYS2_PENCH

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Protein

L-aminoadipate-semialdehyde dehydrogenase large subunit

Gene
lys2
Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

Cofactori

Binds 1 phosphopantetheine covalently Reviewed prediction.

Pathwayi

GO - Molecular functioni

  1. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
  2. phosphopantetheine binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00033; UER00032.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aminoadipate-semialdehyde dehydrogenase large subunit (EC:1.2.1.31)
Alternative name(s):
Alpha-aminoadipate reductase
Short name:
Alpha-AR
Gene namesi
Name:lys2
OrganismiPenicillium chrysogenum (Penicillium notatum)
Taxonomic identifieri5076 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14091409L-aminoadipate-semialdehyde dehydrogenase large subunitPRO_0000193151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei896 – 8961O-(pantetheine 4'-phosphoryl)serine Reviewed prediction

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliO74298.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini863 – 93472Acyl carrierAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR010080. Thioester_reductase-like_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF001617. Alpha-AR. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74298-1 [UniParc]FASTAAdd to Basket

« Hide

MAVGTASLQD RLETWAQRLK NLTVSPLTRD YPDTQKTDSK RVIEAFESLQ     50
LPKAKLTGSS SSFIAFLTAF IILVARLTGD EDIAVGTNSN EDGRAFVIRV 100
PIDTSESFAQ LYAKVDKAYK EGSSQIVPLG SLRSYIQEKS KSERTPVLFR 150
FAAYDAPASS QDYPANTFDT TDLVVNVAPG SAEVELGAYY NQRLFSSARI 200
AFILKQLASI ASNAAANPDE AIGRIDLMTE DQRALLPDPT CNLNWSNFRG 250
AIHDIFTANA ERHPEKLCVV ETQSSSSPHR EFTYRQINEA SNILGHHLVR 300
SGIQRGEVVM VYAYRGVDLV VAVMGILKAG ATFSVIDPAY PPERQNIYLD 350
VARPRALVNI AKATKDAGEL SDIVRTFIDE NLELRTEIPA LALLDDGTLA 400
GGSINGQDVF ANDVALKSKP TGVVVGPDSI PTLSFTSGSE GRPKGVRGRH 450
FSLAYYFPWM SETFKLTPDE KFTMLSGIAH DPIQRDIFTP LFLGAQLLVP 500
AREDIQNEKL AEWIEKYGAT ITHLTPAMGQ ILVGGASAQF PALHHAFFVG 550
DILIKRDCRS LQGLAPNVSI VNMYGTTETQ RAVSYYEIPS YASNEGYLNN 600
MKDVIMAGRG MLDVQMLVVN RYDPTRLCAI GEVGEIYVRA GGLAEGYLGS 650
PELSAKKFLN NWFVNPEIWA EKDQAESRNE PWRQFYVGPR DRLYRSGDLG 700
RYTPSGDVEC SGRADDQVKI RGFRIELGEI DTHLSQHPLV RENVTLVRRD 750
KDEEPTLVSY FVPDMNKWAS WLESKGLKDD DSDSEGMVGL LRRFRPLRDD 800
AREHLRTKLP TYAVPTVIIP LKRMPLNPNG KIDKPALPFP DTAELSAAAP 850
RRASSALQAL SETEQTLAQV WAKLIPNVTS RMIGPDDSFF DLGGHSILAQ 900
QMFFELRRKW RVIDISMNAI FRSPTLKGFA SEIDRLLAME SFATSDDKTL 950
AVQAANEPDD EYSKDAVQLV NELPKTFPQR TEAMLTSEPT VFLTGATGFL 1000
GAHILRDLLT RKSPSTKVVA LVRAKTEELA LERLRSTCRA YGFWDEAWTA 1050
KLQAVCGDLG KPQFGLSQSV WDDLTNRVDA VIHNGALVHW VYPYATLRPA 1100
NVMGTIDALK LCASGKAKQF AFVSSTSALD KDRYVQESER IIAAGGNGIS 1150
EDDDMEGSRV GLGTGYGQSK WAGEYLVKEA GRRGLRGTIV RSGYVLGDSV 1200
TGTTNTDDFL IRMLKGCIQI GLRPNIFNTV NMVPVDHVAR IVIATAFHPP 1250
ATGVNVAHVT GHPRLRFNQF LGALELYGYN VPQVDYVPWS TSLEQYVNDG 1300
EHNDKESQHA LMPLYHFVTS DLPSNTKAPE LDDVNAATAL RADATWSGVD 1350
ASAGAGVTEE LVGLYASYLV QTGFLPAPTV AGARPLPAAQ ISEEQKKTLL 1400
SVGGRGGTS 1409
Length:1,409
Mass (Da):154,842
Last modified:November 1, 1998 - v1
Checksum:iA85DFD397BAB29AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13967 Genomic DNA. Translation: CAA74300.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13967 Genomic DNA. Translation: CAA74300.1 .

3D structure databases

ProteinModelPortali O74298.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00032 .

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR010080. Thioester_reductase-like_dom.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF001617. Alpha-AR. 1 hit.
SUPFAMi SSF47336. SSF47336. 1 hit.
TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the lys2 gene of Penicillium chrysogenum encoding alpha-aminoadipic acid reductase."
    Casqueiro J., Gutierrez S., Banuelos O., Fierro F., Velasco J., Martin J.F.
    Mol. Gen. Genet. 259:549-556(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AS-P-78.

Entry informationi

Entry nameiLYS2_PENCH
AccessioniPrimary (citable) accession number: O74298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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