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Protein

Calcium-transporting ATPase

Gene

KlPMR1

Organism
Kluyveromyces lactis (Yeast) (Candida sphaerica)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:KlPMR1Imported
OrganismiKluyveromyces lactis (Yeast) (Candida sphaerica)Imported
Taxonomic identifieri28985 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 106HelicalUniRule annotationAdd BLAST20
Transmembranei112 – 128HelicalUniRule annotationAdd BLAST17
Transmembranei284 – 303HelicalUniRule annotationAdd BLAST20
Transmembranei309 – 337HelicalUniRule annotationAdd BLAST29
Transmembranei796 – 816HelicalUniRule annotationAdd BLAST21
Transmembranei831 – 848HelicalUniRule annotationAdd BLAST18
Transmembranei868 – 889HelicalUniRule annotationAdd BLAST22
Transmembranei895 – 913HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_451138.1.

Structurei

3D structure databases

ProteinModelPortaliO74296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 108Cation_ATPase_NInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF217. PTHR24093:SF217. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNPFESYL ARDQQPPQPA VDVLSQPNAS LEYCTVSVED TIAQLGTDFD
60 70 80 90 100
NGLSNPSEIA YRKSIWGSNE VLPDEEVSLW KKFLSTFIED PLILLLIGSA
110 120 130 140 150
VISFLMGNID DSISIALAII IVVTVGFVQE YKSEKSLEAL NKLVPAECHL
160 170 180 190 200
TRSGQLSHVL ASNLVPGDLV RFKVGDRIPA DLRIVESIDL CVDESNLTGE
210 220 230 240 250
NEPVHKSSGA VDPKNLLSYP GSIIPVGDRN CIGFMGTLVR EGHGKGIVIA
260 270 280 290 300
TGKHTVFGVF EMMSGIDKPK TPLQTAMDKL GSGFVLHEFV LIGIICLIGI
310 320 330 340 350
IQGRSWLEMF QIAVSLAVAA PEGLPIIVTV TLALGVLRMA KRKAIVRRLP
360 370 380 390 400
SVETLGSVNV ICLDKTGTLT ANHMTVSKIW CLGSMENKTN CLALSKVKER
410 420 430 440 450
PIKMEQDVAT TLRIGNICNN GTYSQEHLKY LGNPTDIAIL ESLQHFGIND
460 470 480 490 500
CRNSVNKINE IPFNSKRKFM AVKTIDANDK VVVYVKGAFE KIVEKSINYI
510 520 530 540 550
GRDGKVHKLK PNDKAIINDA AVALASEGLR TLAFAELEVS ATHGDKEFNE
560 570 580 590 600
DMVEGLTFTG LIAMNDPPRP TVRSAIEELL QGSVHVIMIT GDAENTAVSI
610 620 630 640 650
ARQIGIPVIN PEYGLQVISW NQMTDDQLAS VIDHVNVFAR ATPEHKLNIV
660 670 680 690 700
RALQKRGHIV AMTGDGVNDA PALKLADIGV SMGKMGTDVA KEASDMVLTD
710 720 730 740 750
DDFSTILTAI EEGKGIFNNI KIFLTFQLST SVAALSLVAI STSLKLPNPL
760 770 780 790 800
NAMQILWINI LMDGPPAQSL GVEPVDHEVM RKPPRKRTDK ILTDAVLKRV
810 820 830 840 850
LISACFIIVG TIYVFVKEMA EDGQVTSRDT TMTFTCFVFF DMFNALSCRH
860 870 880 890 900
ATKSIFEIGF FANKMFNYAV SLSLLGQLCA IYIPFFQGIF KTESLSLGDL
910 920 930
LFLLTLSSSV FIGDEIRKYY VKKNRYFQDS YSSSIV
Length:936
Mass (Da):102,437
Last modified:November 1, 1998 - v1
Checksum:i53B891BA891A1611
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001018 Genomic DNA. Translation: CAA04476.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001018 Genomic DNA. Translation: CAA04476.1.

3D structure databases

ProteinModelPortaliO74296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_451138.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF217. PTHR24093:SF217. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO74296_KLULC
AccessioniPrimary (citable) accession number: O74296
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.