ID   O74283_COPCI            Unreviewed;       518 AA.
AC   O74283;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   22-FEB-2023, entry version 45.
DE   SubName: Full=Pheromone receptor {ECO:0000313|EMBL:CAA71963.1};
GN   Name=rcb2 {ECO:0000313|EMBL:CAA71963.1};
OS   Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX   NCBI_TaxID=5346 {ECO:0000313|EMBL:CAA71963.1};
RN   [1] {ECO:0000313|EMBL:CAA71963.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H9 {ECO:0000313|EMBL:CAA71963.1};
RX   PubMed=9539426;
RA   O'Shea S.F., Chaure P.T., Halsall J.R., Olesnicky N.S., Leibbrandt A.,
RA   Connerton I.F., Casselton L.A.;
RT   "A large pheromone and receptor gene complex determines multiple B mating
RT   type specificities in Coprinus cinereus.";
RL   Genetics 148:1081-1090(1998).
RN   [2] {ECO:0000313|EMBL:CAA71963.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H9 {ECO:0000313|EMBL:CAA71963.1};
RX   PubMed=10329622; DOI=10.1093/emboj/18.10.2756;
RA   Olesnicky N.S., Brown A.J., Dowell S.J., Casselton L.A.;
RT   "A constitutively active G-protein-coupled receptor causes mating self-
RT   compatibility in the mushroom Coprinus.";
RL   EMBO J. 18:2756-2763(1999).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 4 family.
CC       {ECO:0000256|ARBA:ARBA00011085}.
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DR   EMBL; Y11081; CAA71963.1; -; Genomic_DNA.
DR   AlphaFoldDB; O74283; -.
DR   VEuPathDB; FungiDB:CC1G_02129; -.
DR   VEuPathDB; FungiDB:CC2G_002514; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004934; F:mating-type alpha-factor pheromone receptor activity; IEA:InterPro.
DR   CDD; cd14966; 7tmD_STE3; 1.
DR   InterPro; IPR000481; GPCR_Pheromne_B_alpha_rcpt.
DR   InterPro; IPR001499; GPCR_STE3.
DR   PANTHER; PTHR28097; PHEROMONE A FACTOR RECEPTOR; 1.
DR   PANTHER; PTHR28097:SF1; PHEROMONE A FACTOR RECEPTOR; 1.
DR   Pfam; PF02076; STE3; 1.
DR   PRINTS; PR00899; GPCRSTE3.
DR   PRINTS; PR00901; PHEROMONEBAR.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:CAA71963.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        38..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        208..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        275..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          414..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  57666 MW;  DAEC9CA88E0260DE CRC64;
     MAPSHDPTYP LFPIFSFLGF ILSAIPFSWH LQAWNSGTCA FMIWTGLACL NGFINSLVWK
     GNSENPAPVW CDISSKLIIG VSIGIPAATL CISRRLYALT SVSTVSVTRA DKRRMVIVDL
     CISFGIPAII MVLHYVVQGH RFDILEDVGC YPVVYNTLLA YFLYIAWPVI LGIFSFVFSC
     LTLRSFWIRR AQFSQLVTSN SSMSMSRYLR LMILALVDIV CTVPLSAYPI YLGTHGVPLH
     PWVSWEETHY GFSRVDRIPA LFWRSSTTYV VGVELTRWLP VLCAFLFFAL FGFASEAQKQ
     YKRAYWAIVK PFGIEPHSAK QPIKVALPSW VKSANLDSTL SPKPHMRQHK QHVSLASTAN
     ASVDIASTVV GSDLEKSACR SSFSSIRSAP PTYSPSVPHH VALDVDIDQR SLFPSSPLSS
     DSTVFCPESP REKLPEPYTY SLPKSQFTRT SFERSNPSSP LSPSNHPGFH RPFSPPITYP
     PTTAHPSAAV AVDVIRATLR PLSQASDNLM FDQPRTMV
//