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Protein

Heat shock protein 60, mitochondrial

Gene

HSP60

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to heat Source: CGD
  • protein refolding Source: InterPro

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60, mitochondrial
Alternative name(s):
60 kDa chaperonin
Protein Cpn60
Gene namesi
Name:HSP60
Ordered Locus Names:CAALFM_CR06490CA
ORF Names:CaO19.717, CaO19.8336
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000174464 HSP60

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005041? – 566Heat shock protein 60, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiO74261

2D gel databases

COMPLUYEAST-2DPAGEiO74261

Interactioni

Protein-protein interaction databases

BioGridi1228332, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliO74261
SMRiO74261
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiO74261
KOiK04077
OMAiTDTDKME
OrthoDBiEOG092C1JWK

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVNSKSSI KTFVRHLSHK ELKFGVEGRA ALLKGVNTLA DAVSVTLGPK
60 70 80 90 100
GRNVLIEQQF GAPKITKDGV TVAKAITLED KFEDLGAKLL QEVASKTNES
110 120 130 140 150
AGDGTTSATV LGRSIFTESV KNVAAGCNPM DLRRGSQAAV EAVIEFLQKN
160 170 180 190 200
KKEITTSEEI AQVATISANG DKHIGDLLAN AMEKVGKEGV ITVKEGKTLE
210 220 230 240 250
DELEVTEGMK FDRGFISPYF ITNTKTGKVE FENPLILLSE KKISSIQDIL
260 270 280 290 300
PSLELSNQTR RPLLIIAEDV DGEALAACIL NKLRGQVQVC AVKAPGFGDN
310 320 330 340 350
RKNTLGDIAI LSGGTVFTEE LDIKPENATI EQLGSAGAVT ITKEDTVLLN
360 370 380 390 400
GEGSKDNLEA RCEQIRSVIA DVHTTEYEKE KLQERLAKLS GGVAVIKVGG
410 420 430 440 450
ASEVEVGEKK DRYEDALNAT RAAVEEGILP GGGTALIKAT KILDEVKEKA
460 470 480 490 500
VNFDQKLGVD TIRAAITKPA KRIIENAGEE GAVIVGKIYD EPEFNKGYDS
510 520 530 540 550
QKGEFTDMIA AGIIDPFKVV KNGLVDASGV ASLLATTECA IVDAPQPKGS
560
PAAPPAPGMG GMPGMF
Length:566
Mass (Da):60,126
Last modified:November 1, 1998 - v1
Checksum:iFAD9C690FE3EB15C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085694 Genomic DNA Translation: AAC34885.1
CP017630 Genomic DNA Translation: AOW31348.1
RefSeqiXP_713077.1, XM_707984.2

Genome annotation databases

EnsemblFungiiAOW31348; AOW31348; CAALFM_CR06490CA
GeneIDi3645275
KEGGical:CAALFM_CR06490CA

Similar proteinsi

Entry informationi

Entry nameiHSP60_CANAL
AccessioniPrimary (citable) accession number: O74261
Secondary accession number(s): A0A1D8PT81, Q59U15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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