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Protein

Heat shock protein 60, mitochondrial

Gene

HSP60

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to heat Source: CGD
  • protein refolding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60, mitochondrial
Alternative name(s):
60 kDa chaperonin
Protein Cpn60
Gene namesi
Name:HSP60
ORF Names:CaO19.717, CaO19.8336
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000174464. HSP60.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 566Heat shock protein 60, mitochondrialPRO_0000005041
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PRIDEiO74261.

2D gel databases

COMPLUYEAST-2DPAGEO74261.

Interactioni

Protein-protein interaction databases

BioGridi1228332. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO74261.
SMRiO74261. Positions 19-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiO74261.
KOiK04077.
OrthoDBiEOG092C1JWK.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVNSKSSI KTFVRHLSHK ELKFGVEGRA ALLKGVNTLA DAVSVTLGPK
60 70 80 90 100
GRNVLIEQQF GAPKITKDGV TVAKAITLED KFEDLGAKLL QEVASKTNES
110 120 130 140 150
AGDGTTSATV LGRSIFTESV KNVAAGCNPM DLRRGSQAAV EAVIEFLQKN
160 170 180 190 200
KKEITTSEEI AQVATISANG DKHIGDLLAN AMEKVGKEGV ITVKEGKTLE
210 220 230 240 250
DELEVTEGMK FDRGFISPYF ITNTKTGKVE FENPLILLSE KKISSIQDIL
260 270 280 290 300
PSLELSNQTR RPLLIIAEDV DGEALAACIL NKLRGQVQVC AVKAPGFGDN
310 320 330 340 350
RKNTLGDIAI LSGGTVFTEE LDIKPENATI EQLGSAGAVT ITKEDTVLLN
360 370 380 390 400
GEGSKDNLEA RCEQIRSVIA DVHTTEYEKE KLQERLAKLS GGVAVIKVGG
410 420 430 440 450
ASEVEVGEKK DRYEDALNAT RAAVEEGILP GGGTALIKAT KILDEVKEKA
460 470 480 490 500
VNFDQKLGVD TIRAAITKPA KRIIENAGEE GAVIVGKIYD EPEFNKGYDS
510 520 530 540 550
QKGEFTDMIA AGIIDPFKVV KNGLVDASGV ASLLATTECA IVDAPQPKGS
560
PAAPPAPGMG GMPGMF
Length:566
Mass (Da):60,126
Last modified:November 1, 1998 - v1
Checksum:iFAD9C690FE3EB15C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085694 Genomic DNA. Translation: AAC34885.1.
AACQ01000135 Genomic DNA. Translation: EAK93958.1.
AACQ01000134 Genomic DNA. Translation: EAK93982.1.
RefSeqiXP_713077.1. XM_707984.1.
XP_713100.1. XM_708007.1.

Genome annotation databases

EnsemblFungiiEAK93958; EAK93958; CaO19.717.
EAK93982; EAK93982; CaO19.8336.
GeneIDi3645238.
3645275.
KEGGical:CaO19.717.
cal:CaO19.8336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085694 Genomic DNA. Translation: AAC34885.1.
AACQ01000135 Genomic DNA. Translation: EAK93958.1.
AACQ01000134 Genomic DNA. Translation: EAK93982.1.
RefSeqiXP_713077.1. XM_707984.1.
XP_713100.1. XM_708007.1.

3D structure databases

ProteinModelPortaliO74261.
SMRiO74261. Positions 19-545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1228332. 1 interaction.

2D gel databases

COMPLUYEAST-2DPAGEO74261.

Proteomic databases

PRIDEiO74261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK93958; EAK93958; CaO19.717.
EAK93982; EAK93982; CaO19.8336.
GeneIDi3645238.
3645275.
KEGGical:CaO19.717.
cal:CaO19.8336.

Organism-specific databases

CGDiCAL0000174464. HSP60.

Phylogenomic databases

InParanoidiO74261.
KOiK04077.
OrthoDBiEOG092C1JWK.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP60_CANAL
AccessioniPrimary (citable) accession number: O74261
Secondary accession number(s): Q59U15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.