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Protein

Guanine nucleotide-binding protein subunit alpha

Gene

SSG-1

Organism
Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471MagnesiumBy similarity
Metal bindingi181 – 1811MagnesiumBy similarity
Binding sitei325 – 3251GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478GTPBy similarity
Nucleotide bindingi175 – 1817GTPBy similarity
Nucleotide bindingi200 – 2045GTPBy similarity
Nucleotide bindingi269 – 2724GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha
Gene namesi
Name:SSG-1
ORF Names:HMPREF1624_06103
OrganismiSporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)
Taxonomic identifieri1391915 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeOphiostomatalesOphiostomataceaeSporothrix
Proteomesi
  • UP000018087 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 353352Guanine nucleotide-binding protein subunit alphaPRO_0000203610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Lipidationi3 – 31S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR002975. Fungi_Gprotein_alpha.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR01241. GPROTEINAFNG.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGMSVEEK EGKARNEEIE NQLKRDRMQQ RNEIKMLLLG AGESGKSTIL
60 70 80 90 100
KQMKLIHEGG YSRDERESFK EIIYSNTVQS MRVILEAMES LELPLEDQRM
110 120 130 140 150
EYHVQTIFMQ PAQIEGEVLP PEVGNAIEAL WKDRGVQECF KRSREYQLND
160 170 180 190 200
SARYYFDNIA RIAAPDYMPD DQDVLRSRVK TTGITETTFI IGDLTYRMFD
210 220 230 240 250
VGGQRSERKK WIHCFENVTT ILFLVAISEY DQLLFEDETV NRMQEALTLF
260 270 280 290 300
DSICNSRWFI KTSIILFLNK IDRFKEKLPI SPMKNYFPDY EGGDDYAAAC
310 320 330 340 350
DYILNRFVNL NQHESKQIYT HFTCATDTTQ IRFVMAAVND IIIQENLRLC

GLI
Length:353
Mass (Da):41,132
Last modified:March 19, 2014 - v4
Checksum:i83BF528AA752F60E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1352RG → AV in AAC34129 (PubMed:10817227).Curated
Sequence conflicti134 – 1352RG → AV in AAC67526 (PubMed:10817227).Curated
Sequence conflicti187 – 1871T → K in AAC34129 (PubMed:10817227).Curated
Sequence conflicti187 – 1871T → K in AAC67526 (PubMed:10817227).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085339 mRNA. Translation: AAC34129.1.
AF068248 Genomic DNA. Translation: AAC67526.1.
KI440847 Genomic DNA. Translation: ERS97932.1.

Genome annotation databases

EnsemblFungiiERS97932; ERS97932; HMPREF1624_06103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085339 mRNA. Translation: AAC34129.1.
AF068248 Genomic DNA. Translation: AAC67526.1.
KI440847 Genomic DNA. Translation: ERS97932.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiERS97932; ERS97932; HMPREF1624_06103.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR002975. Fungi_Gprotein_alpha.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR01241. GPROTEINAFNG.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Presence of a pertussis toxin-sensitive G protein alpha subunit in Sporothrix schenckii."
    Delgado N., Rodriguez-del Valle N.
    Med. Mycol. 38:109-121(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: ATCC 58251 / de Perez 2211183.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 58251 / de Perez 2211183.

Entry informationi

Entry nameiGPA1_SPOS1
AccessioniPrimary (citable) accession number: O74259
Secondary accession number(s): U7PQT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 19, 2014
Last modified: May 11, 2016
This is version 77 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.