Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor steA

Gene

steA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor involved in sexual reproduction. Required for cleistothecial development and ascosporogenesis. Not required for asexual reproduction (conidiation). May act to repress medA expression.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi56 – 165By similarityAdd BLAST110
Zinc fingeri564 – 588C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri594 – 616C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of secondary metabolite biosynthetic process Source: AspGD
  • sexual reproduction Source: UniProtKB
  • sporocarp development involved in sexual reproduction Source: AspGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor steA
Gene namesi
Name:steA
Synonyms:ste12
ORF Names:AN2290
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722681 – 692Transcription factor steAAdd BLAST692

Proteomic databases

PRIDEiO74252

Expressioni

Developmental stagei

Expression is low in vegetative hyphae and increases during conidiophore development.

Interactioni

Protein-protein interaction databases

BioGridi1955935, 1 interactor
STRINGi162425.CADANIAP00008982

Structurei

3D structure databases

ProteinModelPortaliO74252
SMRiO74252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STE12 transcription factor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri564 – 588C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri594 – 616C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000172275
InParanoidiO74252
KOiK11215
OMAiSFRFQAF
OrthoDBiEOG092C21JZ

Family and domain databases

InterProiView protein in InterPro
IPR003120 Ste12
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02200 STE, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD018365 TF_STE, 1 hit
SMARTiView protein in SMART
SM00424 STE, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequencei

Sequence statusi: Complete.

O74252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSQHGAPMA PPQKPETFML SNEAQQSLPH DAQVALQQVD NLKYFLLSAP
60 70 80 90 100
VDWQPDQLIR RFLLPTGDYI SCVLWSNLFH ISGTDIVRCL AFRFQAFGRP
110 120 130 140 150
VKNSKKFEEG IFSDLRNLKA GTDATLEEPK SPFLDFLYKN NCIRTQKKQK
160 170 180 190 200
VFYWYSVPHD RLFLDALERD LKREKMGQEA TTVAVSEPAL SFEFDSSQSL
210 220 230 240 250
YEQLTKAQQA NSSSFAAHAS TTYGQSASPV VRTVDAMPPP QMAPQMAPPS
260 270 280 290 300
IPLLTDESAN SQMYTSIPMP NPIPQNLIKR EADYGAIQYD RNGMPIARIH
310 320 330 340 350
QRHSSMPTFV EYSPAPSFVS SQYEDYSNRG LSFEPVTPPQ HSSHIGPEPA
360 370 380 390 400
YIANEDTGLY TAIPEMSTGS GFNPMMHLPP SNLASAHFPT PARTFHSNVY
410 420 430 440 450
SVLEGSPTYK QRRRRSSIPP GAANPVTTGT HSPAPALSYA AHKPSDLRRS
460 470 480 490 500
VSSSVAPGDT DDSRHESLHR SVNSTYTATL PQKNLMHEMS RNGTPLSSVG
510 520 530 540 550
EHREQSSIPL TQAEDLPALP ANGTVESGAP NGVGHKSDRY ATGPVRRARS
560 570 580 590 600
ATMMELGPYP QKSHSCPIPS CGRLFKRLEH LKRHVRTHTQ ERPYPCPYCN
610 620 630 640 650
KAFSRSDNLA QHRRIHEAQQ DGQPLVHEDD LENDDNESVS HDEDESPSES
660 670 680 690
VHPAVPGVHG MTSMPSSVAL QSTMGSMMGS HMIAPQLLQQ QI
Length:692
Mass (Da):76,695
Last modified:November 1, 1998 - v1
Checksum:iA0B86A6878437C13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080600 mRNA Translation: AAC31206.1
AACD01000038 Genomic DNA Translation: EAA64401.1
BN001307 Genomic DNA Translation: CBF86542.1
RefSeqiXP_659894.1, XM_654802.1

Genome annotation databases

EnsemblFungiiCADANIAT00008982; CADANIAP00008982; CADANIAG00008982
EAA64401; EAA64401; AN2290.2
GeneIDi2875161
KEGGiani:AN2290.2

Similar proteinsi

Entry informationi

Entry nameiSTE12_EMENI
AccessioniPrimary (citable) accession number: O74252
Secondary accession number(s): C8VN37, Q5BAZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health