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Protein

Transcription factor steA

Gene

steA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor involved in sexual reproduction. Required for cleistothecial development and ascosporogenesis. Not required for asexual reproduction (conidiation). May act to repress medA expression.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi56 – 165110By similarityAdd
BLAST
Zinc fingeri564 – 58825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • invasive growth in response to glucose limitation Source: EnsemblFungi
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter by pheromones Source: EnsemblFungi
  • positive regulation of transcription from RNA polymerase II promoter by pheromones Source: EnsemblFungi
  • pseudohyphal growth Source: EnsemblFungi
  • regulation of secondary metabolite biosynthetic process Source: ASPGD
  • sexual reproduction Source: UniProtKB
  • sporocarp development involved in sexual reproduction Source: ASPGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor steA
Gene namesi
Name:steA
Synonyms:ste12
ORF Names:AN2290
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN2290.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: EnsemblFungi
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 692692Transcription factor steAPRO_0000072268Add
BLAST

Expressioni

Developmental stagei

Expression is low in vegetative hyphae and increases during conidiophore development.

Interactioni

Protein-protein interaction databases

BioGridi1955935. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO74252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STE12 transcription factor family.Curated
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri564 – 58825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000172275.
InParanoidiO74252.
KOiK11215.
OMAiSFRFQAF.
OrthoDBiEOG7J44MH.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR003120. Ste12.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02200. STE. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
ProDomiPD018365. TF_STE. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00424. STE. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSQHGAPMA PPQKPETFML SNEAQQSLPH DAQVALQQVD NLKYFLLSAP
60 70 80 90 100
VDWQPDQLIR RFLLPTGDYI SCVLWSNLFH ISGTDIVRCL AFRFQAFGRP
110 120 130 140 150
VKNSKKFEEG IFSDLRNLKA GTDATLEEPK SPFLDFLYKN NCIRTQKKQK
160 170 180 190 200
VFYWYSVPHD RLFLDALERD LKREKMGQEA TTVAVSEPAL SFEFDSSQSL
210 220 230 240 250
YEQLTKAQQA NSSSFAAHAS TTYGQSASPV VRTVDAMPPP QMAPQMAPPS
260 270 280 290 300
IPLLTDESAN SQMYTSIPMP NPIPQNLIKR EADYGAIQYD RNGMPIARIH
310 320 330 340 350
QRHSSMPTFV EYSPAPSFVS SQYEDYSNRG LSFEPVTPPQ HSSHIGPEPA
360 370 380 390 400
YIANEDTGLY TAIPEMSTGS GFNPMMHLPP SNLASAHFPT PARTFHSNVY
410 420 430 440 450
SVLEGSPTYK QRRRRSSIPP GAANPVTTGT HSPAPALSYA AHKPSDLRRS
460 470 480 490 500
VSSSVAPGDT DDSRHESLHR SVNSTYTATL PQKNLMHEMS RNGTPLSSVG
510 520 530 540 550
EHREQSSIPL TQAEDLPALP ANGTVESGAP NGVGHKSDRY ATGPVRRARS
560 570 580 590 600
ATMMELGPYP QKSHSCPIPS CGRLFKRLEH LKRHVRTHTQ ERPYPCPYCN
610 620 630 640 650
KAFSRSDNLA QHRRIHEAQQ DGQPLVHEDD LENDDNESVS HDEDESPSES
660 670 680 690
VHPAVPGVHG MTSMPSSVAL QSTMGSMMGS HMIAPQLLQQ QI
Length:692
Mass (Da):76,695
Last modified:November 1, 1998 - v1
Checksum:iA0B86A6878437C13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080600 mRNA. Translation: AAC31206.1.
AACD01000038 Genomic DNA. Translation: EAA64401.1.
BN001307 Genomic DNA. Translation: CBF86542.1.
RefSeqiXP_659894.1. XM_654802.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008982; CADANIAP00008982; CADANIAG00008982.
EAA64401; EAA64401; AN2290.2.
GeneIDi2875161.
KEGGiani:AN2290.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080600 mRNA. Translation: AAC31206.1.
AACD01000038 Genomic DNA. Translation: EAA64401.1.
BN001307 Genomic DNA. Translation: CBF86542.1.
RefSeqiXP_659894.1. XM_654802.1.

3D structure databases

ProteinModelPortaliO74252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1955935. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00008982; CADANIAP00008982; CADANIAG00008982.
EAA64401; EAA64401; AN2290.2.
GeneIDi2875161.
KEGGiani:AN2290.2.

Organism-specific databases

EuPathDBiFungiDB:AN2290.

Phylogenomic databases

HOGENOMiHOG000172275.
InParanoidiO74252.
KOiK11215.
OMAiSFRFQAF.
OrthoDBiEOG7J44MH.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR003120. Ste12.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02200. STE. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
ProDomiPD018365. TF_STE. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00424. STE. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Aspergillus SteA (Sterile12-like) is a homeodomain-C2/H2-Zn+2 finger transcription factor required for sexual reproduction."
    Vallim M.A., Miller K.Y., Miller B.L.
    Mol. Microbiol. 36:290-301(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiSTE12_EMENI
AccessioniPrimary (citable) accession number: O74252
Secondary accession number(s): C8VN37, Q5BAZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.