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Protein

Plasma membrane ATPase

Gene

pma1

Organism
Cryptococcus neoformans (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane ATPaseUniRule annotation (EC:3.6.3.6UniRule annotation)
Gene namesi
Name:pma1Imported
OrganismiCryptococcus neoformans (Filobasidiella neoformans)Imported
Taxonomic identifieri5207 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei123 – 15028HelicalUniRule annotationAdd
BLAST
Transmembranei162 – 17817HelicalUniRule annotationAdd
BLAST
Transmembranei306 – 33126HelicalUniRule annotationAdd
BLAST
Transmembranei343 – 36624HelicalUniRule annotationAdd
BLAST
Transmembranei714 – 73623HelicalUniRule annotationAdd
BLAST
Transmembranei742 – 76120HelicalUniRule annotationAdd
BLAST
Transmembranei773 – 80028HelicalUniRule annotationAdd
BLAST
Transmembranei820 – 84122HelicalUniRule annotationAdd
BLAST
Transmembranei853 – 87422HelicalUniRule annotationAdd
BLAST
Transmembranei886 – 90318HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO74242.

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_568571.1.

Structurei

3D structure databases

ProteinModelPortaliO74242.
SMRiO74242. Positions 78-912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 15173Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000160005.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDHEKVGHT EEIPTKESSL ENKVQGEEVP AAAAADEEPR KKREYKEMEH
60 70 80 90 100
KTEGDLHAKV DMNTIQFTAA DLYDKDKVDI EHVVMEEVYQ LLQCTDAGLT
110 120 130 140 150
EAEATDRIGI FGPNKLEEKS ENVLLQFLSF MWNPLSWVME GAALVAIALS
160 170 180 190 200
NGGGTPPDWQ DFVGIILLLF VNSTIGFVEE RNAGNAVKAL MDSLAPKARV
210 220 230 240 250
KRDGQWKEIE SSELVPGDLI AFKHGDVCPS DCRLVEAIDV SMDQAALTGE
260 270 280 290 300
SLPVGKHEGD ECFSGSTCKQ GEAEGIVIAT GPNTFFGRAA TLVGQDNDQV
310 320 330 340 350
GHLQQVLARI GTFCLVSIGI FVLLEILILY ADFRYPYRRG LDNILVLLIG
360 370 380 390 400
GIPIAMPTVL SVTLAVGAQQ LAKHKAIVTR ITAIEELAGV TILCSDKTGT
410 420 430 440 450
LTTNKLTIDK ENVKCYSKWD VEGVCLLAAY ASRTENQDAI DGCVVGTLPD
460 470 480 490 500
PQQARAGIKL LDFKPFNPVD KRTEITYRDE MDGGKLKRAT KGMTGIIIEI
510 520 530 540 550
CTRNKTNELE DQLEADVEEF ARRGLRALAV AFEDVAGDDP SAEGNGFELV
560 570 580 590 600
GLLSIFDPPR SDTKKTIDDA MALGVKVKMV TGDQLAIAKE TGRRLGLGDH
610 620 630 640 650
MYPAKVLKEG PEAGSKHANL DEMIMDADGF AGVFPEHKFE IVKRIQNLGH
660 670 680 690 700
LCAMTGDGAN DAPALSRANV GIAVEGATDA ARGAADIVLT EPGLSTIVHA
710 720 730 740 750
IYGSRVIFQR MRNYAIYACA VTIRIVLCFA IMAFAWRFDF PPFMVLIIAV
760 770 780 790 800
LNDGTIMTLS LDRVLPSTTP DSWDLAEVFS FGVAYGVYLS ASTIALYATM
810 820 830 840 850
ENTTFFEDRF GVEPLKGNSY GGHMVIYLQV AIISQALIFV TRSHGPSWTE
860 870 880 890 900
RPSVALMLAF CLAQLVSSII AAYADWSFSQ VHSVSGGWIG IVWIWNIVWY
910 920 930 940 950
FPLDGIKFIM KKTVIAALQR RKARKAGPAV ADAALHRAPS RHESLYSNRT
960 970 980 990
NFLTRAANRL RGGAKISMSQ NELQRFSSIQ AQQSGAALTR AHSRPAA
Length:997
Mass (Da):108,694
Last modified:November 1, 1998 - v1
Checksum:iECAEB09A66F7A744
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077766 mRNA. Translation: AAC27788.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077766 mRNA. Translation: AAC27788.1.

3D structure databases

ProteinModelPortaliO74242.
SMRiO74242. Positions 78-912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.XP_568571.1.

Proteomic databases

PaxDbiO74242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0205. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000160005.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequencing and heterologous expression in Saccharomyces cerevisiae of a Cryptococcus neoformans cDNA encoding a plasma membrane H(+)-ATPase."
    Gorgojo B., Portillo F., Martinez-Suarez J.V.
    Biochim. Biophys. Acta 1509:103-110(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B-3501Imported.

Entry informationi

Entry nameiO74242_CRYNE
AccessioniPrimary (citable) accession number: O74242
Secondary accession number(s): Q55HJ5, Q5K735
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: April 13, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.