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Protein

Heat shock protein hsp88

Gene

hsp88

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein hsp88
Gene namesi
Name:hsp88
ORF Names:NCU05269
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 4, Linkage Group IV

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Heat shock protein hsp88PRO_0000078373Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PRIDEiO74225.

Expressioni

Inductioni

By heat shock.

Interactioni

Subunit structurei

Binds hsp30 independent of temperature or substrate.

Structurei

3D structure databases

ProteinModelPortaliO74225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

HOGENOMiHOG000228138.
InParanoidiO74225.
KOiK09489.
OrthoDBiEOG092C17NN.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVGVDFGA LNTVIAVARN RGVDVITNEV SNRATPSLVG FGPKSRYIGE
60 70 80 90 100
PAKTQEISNL KNTVGCLKRL AGRTLDDPDV AIEQQFISAT LVDVNGEVGA
110 120 130 140 150
EVTYLGEKRK FSATELIAMF MSKIKQTTQA EVKVAVQELV LSVPAWFTDK
160 170 180 190 200
QRRSILDAAE IAGLRPLRLI NDTTAAALGW GITKLDLPGP EEKPRRVAFV
210 220 230 240 250
DVGYSNYTCS IVEFKKGELS VKSTACDRHF GGRNFDKALL DHLHKEFLGK
260 270 280 290 300
YKIDIFTNPK AVCRVLAAAE KLKKILSANQ QAPLNIESLM NDIDVRAMIT
310 320 330 340 350
RQEFEAMVEP LLAKVHVPLE QALADAKLTK DDIDIIEVVG GGSRVPSVKE
360 370 380 390 400
RIQAFFGKQL SFTMNQDEAI ARGCAFSCAI LSPVFKVRDF QVQDIINYPI
410 420 430 440 450
EFTWEKDADI PDEDTSLVVF NKGNVLPSTK ILTFYRKQPF DLEARYTNPE
460 470 480 490 500
ELPGKTSPFI GRFSIKGVHA TEGPEDFMIC KLKARINIHG ILNVESAYYV
510 520 530 540 550
EDQEVEEEVK DENGDVVMEG DKPKTRKVKK QVRKGELPVV SATPSLDPAA
560 570 580 590 600
KNAAIEREQA MIMEDKLVAD TEEKKNELET YIYDLRNKLD DQYADLASEE
610 620 630 640 650
EKEKIRAKLM EVEDWLYDEG DDATKAVYVA KIEEIRALAG PVVQRYFDKV
660 670 680 690 700
EAERQALQEK LEAEKAAKKA EEEARKAKEA AEKAAQEGAK DDEMTDADAP

KPVVEEA
Length:707
Mass (Da):78,674
Last modified:November 1, 1998 - v1
Checksum:i8B077E8CC08BB4C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069523 mRNA. Translation: AAC23862.1.
CM002239 Genomic DNA. Translation: ESA43073.1.
CM002239 Genomic DNA. Translation: ESA43074.1.
RefSeqiXP_011394150.1. XM_011395848.1.
XP_011394151.1. XM_011395849.1.

Genome annotation databases

EnsemblFungiiEFNCRT00000005032; EFNCRP00000005028; EFNCRG00000005025.
GeneIDi3877907.
KEGGincr:NCU05269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069523 mRNA. Translation: AAC23862.1.
CM002239 Genomic DNA. Translation: ESA43073.1.
CM002239 Genomic DNA. Translation: ESA43074.1.
RefSeqiXP_011394150.1. XM_011395848.1.
XP_011394151.1. XM_011395849.1.

3D structure databases

ProteinModelPortaliO74225.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO74225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFNCRT00000005032; EFNCRP00000005028; EFNCRG00000005025.
GeneIDi3877907.
KEGGincr:NCU05269.

Phylogenomic databases

HOGENOMiHOG000228138.
InParanoidiO74225.
KOiK09489.
OrthoDBiEOG092C17NN.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 2 hits.
SSF100934. SSF100934. 1 hit.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP88_NEUCR
AccessioniPrimary (citable) accession number: O74225
Secondary accession number(s): Q7RVE6, V5IPJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.