O74201 (UBC2_CANAL) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 86.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ubiquitin-conjugating enzyme E2 2 EC=6.3.2.19 Alternative name(s): Radiation sensitivity protein 6 Ubiquitin carrier protein UBC2 Ubiquitin-protein ligase UBC2 | ||||||
| Gene names |
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| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome] | ||||||
| Taxonomic identifier | 237561 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › ![]() |
Protein attributes
| Sequence length | 179 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation By similarity. Ref.2 |
| Catalytic activity | ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. |
| Pathway | |
| Subcellular location | |
| Induction | Up-regulated by UV radiation, heat shock, osmotic stress and nitrogen starvation. Ref.2 |
| Sequence similarities | Belongs to the ubiquitin-conjugating enzyme family. |
| Sequence caution | The sequence EAK96213.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and characterisation of CaRAD6 gene from Candida albicans." Leng P., Brown A.J.P. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 3153A. |
| [2] | "Rad6p represses yeast-hypha morphogenesis in the human fungal pathogen Candida albicans." Leng P., Sudbery P.E., Brown A.J.P. Mol. Microbiol. 35:1264-1275(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION. Strain: 3153A. |
| [3] | "The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF036707 mRNA. Translation: AAC24765.1. AF118145 Genomic DNA. Translation: AAD45241.1. AACQ01000089 Genomic DNA. Translation: EAK96213.1. Sequence problems. |
| RefSeq | XP_715243.1. XM_710150.1. XP_888992.1. XM_883899.1. |
3D structure databases | |
| ProteinModelPortal | O74201. |
| SMR | O74201. Positions 2-154. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 5476.CAL0003164. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3643143. 3703919. |
| KEGG | cal:CaO19.7195. cal:CaO19_7195. |
Organism-specific databases | |
| CGD | CAL0003164. RAD6. |
Phylogenomic databases | |
| eggNOG | COG5078. |
Enzyme and pathway databases | |
| UniPathway | UPA00143. |
Family and domain databases | |
| Gene3D | 3.10.110.10. 1 hit. |
| InterPro | IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view] |
| Pfam | PF00179. UQ_con. 1 hit. [Graphical view] |
| SUPFAM | SSF54495. UBQ-conjugat/RWD-like. 1 hit. |
| PROSITE | PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UBC2_CANAL | ||||||||
| Accession | Primary (citable) accession number: O74201 Secondary accession number(s): Q5A0A0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
