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O74201

- UBC2_CANAL

UniProt

O74201 - UBC2_CANAL

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Protein

Ubiquitin-conjugating enzyme E2 2

Gene
UBC2, RAD6, CaO19.7195
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation By similarity.1 Publication

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: CGD

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: CGD
  2. cellular response to UV Source: CGD
  3. chromatin modification Source: UniProtKB-KW
  4. DNA repair Source: UniProtKB-KW
  5. filamentous growth Source: CGD
  6. protein autoubiquitination Source: CGD
  7. protein import into peroxisome matrix, receptor recycling Source: CGD
  8. protein monoubiquitination Source: CGD
  9. regulation of transcription, DNA-templated Source: UniProtKB-KW
  10. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Ligase

Keywords - Biological processi

DNA damage, DNA repair, Sporulation, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 2 (EC:6.3.2.19)
Alternative name(s):
Radiation sensitivity protein 6
Ubiquitin carrier protein UBC2
Ubiquitin-protein ligase UBC2
Gene namesi
Name:UBC2
Synonyms:RAD6
ORF Names:CaO19.7195
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003164. RAD6.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. peroxisome Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Ubiquitin-conjugating enzyme E2 2PRO_0000082528Add
BLAST

Expressioni

Inductioni

Up-regulated by UV radiation, heat shock, osmotic stress and nitrogen starvation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003164.

Structurei

3D structure databases

ProteinModelPortaliO74201.
SMRiO74201. Positions 2-154.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 17929Acidic tailAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
OrthoDBiEOG7SBP18.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74201-1 [UniParc]FASTAAdd to Basket

« Hide

MSTPARRRLM RDFKRMQQDP PSGVSASPLP DNVMKWNAVI IGPSDTPFED    50
GTFRLLLSFD EQYPNKPPQV KFISEMFHPN VYASGELCLD ILQNRWSPTY 100
DVSSILTSVQ SLLNDPNISS PANVEAANLY KDHRSLYVKR VRETVENSWN 150
DDDDEEEEEE DEDEAEDEDD DDDDNIDED 179
Length:179
Mass (Da):20,576
Last modified:November 1, 1998 - v1
Checksum:i24A081B5F8E4D316
GO

Sequence cautioni

The sequence EAK96213.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF036707 mRNA. Translation: AAC24765.1.
AF118145 Genomic DNA. Translation: AAD45241.1.
AACQ01000089 Genomic DNA. Translation: EAK96213.1. Sequence problems.
RefSeqiXP_715243.1. XM_710150.1.
XP_888992.1. XM_883899.1.

Genome annotation databases

GeneIDi3643143.
3703919.
KEGGical:CaO19.7195.
cal:CaO19_7195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF036707 mRNA. Translation: AAC24765.1 .
AF118145 Genomic DNA. Translation: AAD45241.1 .
AACQ01000089 Genomic DNA. Translation: EAK96213.1 . Sequence problems.
RefSeqi XP_715243.1. XM_710150.1.
XP_888992.1. XM_883899.1.

3D structure databases

ProteinModelPortali O74201.
SMRi O74201. Positions 2-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643143.
3703919.
KEGGi cal:CaO19.7195.
cal:CaO19_7195.

Organism-specific databases

CGDi CAL0003164. RAD6.

Phylogenomic databases

eggNOGi COG5078.
OrthoDBi EOG7SBP18.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterisation of CaRAD6 gene from Candida albicans."
    Leng P., Brown A.J.P.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 3153A.
  2. "Rad6p represses yeast-hypha morphogenesis in the human fungal pathogen Candida albicans."
    Leng P., Sudbery P.E., Brown A.J.P.
    Mol. Microbiol. 35:1264-1275(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    Strain: 3153A.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiUBC2_CANAL
AccessioniPrimary (citable) accession number: O74201
Secondary accession number(s): Q5A0A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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