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O74201

- UBC2_CANAL

UniProt

O74201 - UBC2_CANAL

Protein

Ubiquitin-conjugating enzyme E2 2

Gene

UBC2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: CGD

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: CGD
    2. cellular response to UV Source: CGD
    3. chromatin modification Source: UniProtKB-KW
    4. DNA repair Source: UniProtKB-KW
    5. filamentous growth Source: CGD
    6. protein autoubiquitination Source: CGD
    7. protein import into peroxisome matrix, receptor recycling Source: CGD
    8. protein monoubiquitination Source: CGD
    9. regulation of transcription, DNA-templated Source: UniProtKB-KW
    10. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Ligase

    Keywords - Biological processi

    DNA damage, DNA repair, Sporulation, Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 2 (EC:6.3.2.19)
    Alternative name(s):
    Radiation sensitivity protein 6
    Ubiquitin carrier protein UBC2
    Ubiquitin-protein ligase UBC2
    Gene namesi
    Name:UBC2
    Synonyms:RAD6
    ORF Names:CaO19.7195
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003164. RAD6.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. peroxisome Source: CGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Ubiquitin-conjugating enzyme E2 2PRO_0000082528Add
    BLAST

    Expressioni

    Inductioni

    Up-regulated by UV radiation, heat shock, osmotic stress and nitrogen starvation.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0003164.

    Structurei

    3D structure databases

    ProteinModelPortaliO74201.
    SMRiO74201. Positions 2-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni151 – 17929Acidic tailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    OrthoDBiEOG7SBP18.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74201-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTPARRRLM RDFKRMQQDP PSGVSASPLP DNVMKWNAVI IGPSDTPFED    50
    GTFRLLLSFD EQYPNKPPQV KFISEMFHPN VYASGELCLD ILQNRWSPTY 100
    DVSSILTSVQ SLLNDPNISS PANVEAANLY KDHRSLYVKR VRETVENSWN 150
    DDDDEEEEEE DEDEAEDEDD DDDDNIDED 179
    Length:179
    Mass (Da):20,576
    Last modified:November 1, 1998 - v1
    Checksum:i24A081B5F8E4D316
    GO

    Sequence cautioni

    The sequence EAK96213.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036707 mRNA. Translation: AAC24765.1.
    AF118145 Genomic DNA. Translation: AAD45241.1.
    AACQ01000089 Genomic DNA. Translation: EAK96213.1. Sequence problems.
    RefSeqiXP_715243.1. XM_710150.1.
    XP_888992.1. XM_883899.1.

    Genome annotation databases

    GeneIDi3643143.
    3703919.
    KEGGical:CaO19.7195.
    cal:CaO19_7195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036707 mRNA. Translation: AAC24765.1 .
    AF118145 Genomic DNA. Translation: AAD45241.1 .
    AACQ01000089 Genomic DNA. Translation: EAK96213.1 . Sequence problems.
    RefSeqi XP_715243.1. XM_710150.1.
    XP_888992.1. XM_883899.1.

    3D structure databases

    ProteinModelPortali O74201.
    SMRi O74201. Positions 2-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643143.
    3703919.
    KEGGi cal:CaO19.7195.
    cal:CaO19_7195.

    Organism-specific databases

    CGDi CAL0003164. RAD6.

    Phylogenomic databases

    eggNOGi COG5078.
    OrthoDBi EOG7SBP18.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterisation of CaRAD6 gene from Candida albicans."
      Leng P., Brown A.J.P.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 3153A.
    2. "Rad6p represses yeast-hypha morphogenesis in the human fungal pathogen Candida albicans."
      Leng P., Sudbery P.E., Brown A.J.P.
      Mol. Microbiol. 35:1264-1275(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
      Strain: 3153A.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiUBC2_CANAL
    AccessioniPrimary (citable) accession number: O74201
    Secondary accession number(s): Q5A0A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3