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Protein

Endochitinase 11

Gene

chi11

Organism
Metarhizium anisopliae (Entomophthora anisopliae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Participates in the infection process and directly acts in the penetration process of the host cuticle.1 Publication

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.1 Publication

pH dependencei

Optimum pH is 5.0.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei346Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation, Virulence
LigandChitin-binding

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.
mycoCLAPiCHI18K_METAN.

Names & Taxonomyi

Protein namesi
Recommended name:
Endochitinase 11 (EC:3.2.1.14)
Alternative name(s):
Chitinase 11
Gene namesi
Name:chi11
OrganismiMetarhizium anisopliae (Entomophthora anisopliae)
Taxonomic identifieri5530 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaeMetarhizium

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000042987225 – 522Endochitinase 11Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO74199.
SMRiO74199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR001223. Glyco_hydro18_cat.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFSMVMFTE RWWVGSKDCP RVPALENSNN PWRLERTATA AELSQYGNPT
60 70 80 90 100
TCEIDNGGVI VADGFQASKG YTGDSIVDYN DAHYKTSVDQ DAWGFVRAAY
110 120 130 140 150
NRGRNTNRQS SGPHPLCTRK CIAWLLMGRL MNAVLTQSDN PALVPNQNAT
160 170 180 190 200
GSNSRPWKPL GKAQSYSNEE LNNAPQFNPE TLYASDTLIR FNGVNYISQS
210 220 230 240 250
KEQKVSPSDS NPWRVFVDWT GTKERVGTPK KAWPKHVYAP YVDFTLNTIP
260 270 280 290 300
DLRALAKNHN VNHFTLAFVV SKDANTTCGT AYGMQNYAQY SKIKALREAG
310 320 330 340 350
GDVMLSIGGA NNAPLAASCK NVDDLMQHYY DIVDNLNLKV LDFDIEGTWV
360 370 380 390 400
AVQASIERRN LAVKKVQDKW KSEGKDIAIW YTLPILPTGL TPEGMNVLSD
410 420 430 440 450
AKAKGVELAG VNVMTMDYGN AICQSANTEG QNIHGKCATS AIAFLHSQLK
460 470 480 490 500
GLHPNKSDAE IDAMMGTTPM VGVNDVQGEV FYLSDARLVM QDAQKRNLGM
510 520
VGIWSIARDL PAALTCLRNS TA
Length:522
Mass (Da):57,454
Last modified:November 1, 1998 - v1
Checksum:i8A01FE69689FD162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036320 mRNA. Translation: AAC33265.1.

Entry informationi

Entry nameiCHI11_METAN
AccessioniPrimary (citable) accession number: O74199
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: November 1, 1998
Last modified: May 10, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families