ID   ERG6_CANAL              Reviewed;         376 AA.
AC   O74198; Q5AJG1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   26-MAY-2009, entry version 45.
DE   RecName: Full=Sterol 24-C-methyltransferase;
DE            EC=2.1.1.41;
DE   AltName: Full=Delta(24)-sterol C-methyltransferase;
GN   Name=ERG6; ORFNames=CaO19.1631, CaO19.9199;
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales;
OC   Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=98253976; PubMed=9593144;
RA   Jensen-Pergakes K.L., Kennedy M.A., Lees N.D., Barbuch R., Koegel C.,
RA   Bard M.;
RT   "Sequencing, disruption, and characterization of the Candida albicans
RT   sterol methyltransferase (ERG6) gene: drug susceptibility studies in
RT   erg6 mutants.";
RL   Antimicrob. Agents Chemother. 42:1160-1167(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
RA   Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
RA   Davis R.W., Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
CC   -!- FUNCTION: Catalyzes the methyl transfer from S-adenosyl-methionine
CC       to the C-24 of zymosterol to form fecosterol.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 5-alpha-cholesta-
CC       8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-
CC       alpha-cholest-8-en-3-beta-ol.
CC   -!- PATHWAY: Steroid metabolism; ergosterol biosynthesis; ergosterol
CC       from zymosterol: step 1/5.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. ERG6
CC       family.
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DR   EMBL; AF031941; AAC26626.1; -; Genomic_DNA.
DR   EMBL; AACQ01000014; EAL02792.1; -; Genomic_DNA.
DR   EMBL; AACQ01000013; EAL02920.1; -; Genomic_DNA.
DR   RefSeq; XP_721588.1; -.
DR   RefSeq; XP_721708.1; -.
DR   GeneID; 3636655; -.
DR   GeneID; 3636783; -.
DR   CGD; CAL0006397; ERG6.
DR   OMA; O74198; FVKGDFM.
DR   BRENDA; 2.1.1.41; 1124.
DR   GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:EC.
DR   GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR013705; Sterol_MeTrfase_C.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   Pfam; PF08498; Sterol_MT_C; 1.
PE   3: Inferred from homology;
KW   Lipid synthesis; Methyltransferase; S-adenosyl-L-methionine;
KW   Steroid biosynthesis; Sterol biosynthesis; Transferase.
FT   CHAIN         1    376       Sterol 24-C-methyltransferase.
FT                                /FTId=PRO_0000124789.
SQ   SEQUENCE   376 AA;  43086 MW;  369D094AFCDED0A0 CRC64;
     MSPVQLAEKN YERDEQFTKA LHGESYKKTG LSALIAKSKD AASVAAEGYF KHWDGGISKD
     DEEKRLNDYS QLTHHYYNLV TDFYEYGWGS SFHFSRYYKG EAFRQATARH EHFLAHKMNL
     NENMKVLDVG CGVGGPGREI TRFTDCEIVG LNNNDYQIER ANHYAKKYHL DHKLSYVKGD
     FMQMDFEPES FDAVYAIEAT VHAPVLEGVY SEIYKVLKPG GIFGVYEWVM TDKYDETNEE
     HRKIAYGIEV GDGIPKMYSR KVAEQALKNV GFEIEYQKDL ADVDDEIPWY YPLSGDLKFC
     QTFGDYLTVF RTSRIGRFIT TESVGLMEKI GLAPKGSKQV THALEDAAVN LVEGGRQKLF
     TPMMLYVVRK PLEKKD
//