Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O74198

- ERG6_CANAL

UniProt

O74198 - ERG6_CANAL

Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: CGD

    GO - Biological processi

    1. cellular response to drug Source: CGD
    2. ergosterol biosynthetic process Source: CGD

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00768; UER00760.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol 24-C-methyltransferase (EC:2.1.1.41)
    Alternative name(s):
    Delta(24)-sterol C-methyltransferase
    Gene namesi
    Name:ERG6
    ORF Names:CaO19.1631, CaO19.9199
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0006397. ERG6.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: CGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Sterol 24-C-methyltransferasePRO_0000124789Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0006397.

    Structurei

    3D structure databases

    ProteinModelPortaliO74198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0500.
    KOiK00559.
    OrthoDBiEOG7DVDMW.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74198-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPVQLAEKN YERDEQFTKA LHGESYKKTG LSALIAKSKD AASVAAEGYF    50
    KHWDGGISKD DEEKRLNDYS QLTHHYYNLV TDFYEYGWGS SFHFSRYYKG 100
    EAFRQATARH EHFLAHKMNL NENMKVLDVG CGVGGPGREI TRFTDCEIVG 150
    LNNNDYQIER ANHYAKKYHL DHKLSYVKGD FMQMDFEPES FDAVYAIEAT 200
    VHAPVLEGVY SEIYKVLKPG GIFGVYEWVM TDKYDETNEE HRKIAYGIEV 250
    GDGIPKMYSR KVAEQALKNV GFEIEYQKDL ADVDDEIPWY YPLSGDLKFC 300
    QTFGDYLTVF RTSRIGRFIT TESVGLMEKI GLAPKGSKQV THALEDAAVN 350
    LVEGGRQKLF TPMMLYVVRK PLEKKD 376
    Length:376
    Mass (Da):43,086
    Last modified:November 1, 1998 - v1
    Checksum:i369D094AFCDED0A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031941 Genomic DNA. Translation: AAC26626.1.
    AACQ01000014 Genomic DNA. Translation: EAL02792.1.
    AACQ01000013 Genomic DNA. Translation: EAL02920.1.
    RefSeqiXP_721588.1. XM_716495.1.
    XP_721708.1. XM_716615.1.

    Genome annotation databases

    GeneIDi3636655.
    3636783.
    KEGGical:CaO19.1631.
    cal:CaO19.9199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031941 Genomic DNA. Translation: AAC26626.1 .
    AACQ01000014 Genomic DNA. Translation: EAL02792.1 .
    AACQ01000013 Genomic DNA. Translation: EAL02920.1 .
    RefSeqi XP_721588.1. XM_716495.1.
    XP_721708.1. XM_716615.1.

    3D structure databases

    ProteinModelPortali O74198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0006397.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3636655.
    3636783.
    KEGGi cal:CaO19.1631.
    cal:CaO19.9199.

    Organism-specific databases

    CGDi CAL0006397. ERG6.

    Phylogenomic databases

    eggNOGi COG0500.
    KOi K00559.
    OrthoDBi EOG7DVDMW.

    Enzyme and pathway databases

    UniPathwayi UPA00768 ; UER00760 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants."
      Jensen-Pergakes K.L., Kennedy M.A., Lees N.D., Barbuch R., Koegel C., Bard M.
      Antimicrob. Agents Chemother. 42:1160-1167(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiERG6_CANAL
    AccessioniPrimary (citable) accession number: O74198
    Secondary accession number(s): Q5AJG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3