Sterol 24-C-methyltransferase - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

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O74198 (ERG6_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sterol 24-C-methyltransferase
EC=2.1.1.41

Alternative name(s):
Delta(24)-sterol C-methyltransferase

Gene names

Name:	ERG6
ORF Names:	CaO19.1631, CaO19.9199

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.
Catalytic activity	S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
Pathway	Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Sequence similarities	Belongs to the methyltransferase superfamily. ERG6 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	cellular response to drug Inferred from mutant phenotype. Source: CGD ergosterol biosynthetic process Inferred from genetic interaction Ref.1. Source: CGD
Cellular component	plasma membrane Inferred from direct assay. Source: CGD
Molecular function	sterol 24-C-methyltransferase activity Inferred from direct assay. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 376

376

Sterol 24-C-methyltransferase

PRO_0000124789

Sequences

Sequence

Length

Mass (Da)

Tools

O74198 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 369D094AFCDED0A0
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FASTA

376

43,086

        10         20         30         40         50         60 
MSPVQLAEKN YERDEQFTKA LHGESYKKTG LSALIAKSKD AASVAAEGYF KHWDGGISKD 

        70         80         90        100        110        120 
DEEKRLNDYS QLTHHYYNLV TDFYEYGWGS SFHFSRYYKG EAFRQATARH EHFLAHKMNL 

       130        140        150        160        170        180 
NENMKVLDVG CGVGGPGREI TRFTDCEIVG LNNNDYQIER ANHYAKKYHL DHKLSYVKGD 

       190        200        210        220        230        240 
FMQMDFEPES FDAVYAIEAT VHAPVLEGVY SEIYKVLKPG GIFGVYEWVM TDKYDETNEE 

       250        260        270        280        290        300 
HRKIAYGIEV GDGIPKMYSR KVAEQALKNV GFEIEYQKDL ADVDDEIPWY YPLSGDLKFC 

       310        320        330        340        350        360 
QTFGDYLTVF RTSRIGRFIT TESVGLMEKI GLAPKGSKQV THALEDAAVN LVEGGRQKLF 

       370 
TPMMLYVVRK PLEKKD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants." Jensen-Pergakes K.L., Kennedy M.A., Lees N.D., Barbuch R., Koegel C., Bard M. Antimicrob. Agents Chemother. 42:1160-1167(1998) [PubMed: 9593144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF031941 Genomic DNA. Translation: AAC26626.1. AACQ01000014 Genomic DNA. Translation: EAL02792.1. AACQ01000013 Genomic DNA. Translation: EAL02920.1.
RefSeq	XP_721588.1. XM_716495.1. XP_721708.1. XM_716615.1.
3D structure databases
ProteinModelPortal	O74198.
ModBase	Search...
Protein-protein interaction databases
STRING	O74198.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3636655. 3636783.
KEGG	cal:CaO19.1631. cal:CaO19.9199.
Organism-specific databases
CGD	CAL0006397. ERG6.
Phylogenomic databases
PhylomeDB	O74198.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view]
KO	K00559.
Pfam	PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERG6_CANAL

Accession

Primary (citable) accession number: O74198
Secondary accession number(s): Q5AJG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program