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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: CGD

GO - Biological processi

  1. cellular response to drug Source: CGD
  2. ergosterol biosynthetic process Source: CGD
  3. methylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
ORF Names:CaO19.1631, CaO19.9199
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0006397. ERG6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. plasma membrane Source: CGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Sterol 24-C-methyltransferasePRO_0000124789Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0006397.

Structurei

3D structure databases

ProteinModelPortaliO74198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0500.
InParanoidiO74198.
KOiK00559.
OrthoDBiEOG7DVDMW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR030384. MeTrfase_SMT.
IPR029063. SAM-dependent_MTases.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPVQLAEKN YERDEQFTKA LHGESYKKTG LSALIAKSKD AASVAAEGYF
60 70 80 90 100
KHWDGGISKD DEEKRLNDYS QLTHHYYNLV TDFYEYGWGS SFHFSRYYKG
110 120 130 140 150
EAFRQATARH EHFLAHKMNL NENMKVLDVG CGVGGPGREI TRFTDCEIVG
160 170 180 190 200
LNNNDYQIER ANHYAKKYHL DHKLSYVKGD FMQMDFEPES FDAVYAIEAT
210 220 230 240 250
VHAPVLEGVY SEIYKVLKPG GIFGVYEWVM TDKYDETNEE HRKIAYGIEV
260 270 280 290 300
GDGIPKMYSR KVAEQALKNV GFEIEYQKDL ADVDDEIPWY YPLSGDLKFC
310 320 330 340 350
QTFGDYLTVF RTSRIGRFIT TESVGLMEKI GLAPKGSKQV THALEDAAVN
360 370
LVEGGRQKLF TPMMLYVVRK PLEKKD
Length:376
Mass (Da):43,086
Last modified:November 1, 1998 - v1
Checksum:i369D094AFCDED0A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031941 Genomic DNA. Translation: AAC26626.1.
AACQ01000014 Genomic DNA. Translation: EAL02792.1.
AACQ01000013 Genomic DNA. Translation: EAL02920.1.
RefSeqiXP_721588.1. XM_716495.1.
XP_721708.1. XM_716615.1.

Genome annotation databases

GeneIDi3636655.
3636783.
KEGGical:CaO19.1631.
cal:CaO19.9199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031941 Genomic DNA. Translation: AAC26626.1.
AACQ01000014 Genomic DNA. Translation: EAL02792.1.
AACQ01000013 Genomic DNA. Translation: EAL02920.1.
RefSeqiXP_721588.1. XM_716495.1.
XP_721708.1. XM_716615.1.

3D structure databases

ProteinModelPortaliO74198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0006397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3636655.
3636783.
KEGGical:CaO19.1631.
cal:CaO19.9199.

Organism-specific databases

CGDiCAL0006397. ERG6.

Phylogenomic databases

eggNOGiCOG0500.
InParanoidiO74198.
KOiK00559.
OrthoDBiEOG7DVDMW.

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR030384. MeTrfase_SMT.
IPR029063. SAM-dependent_MTases.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants."
    Jensen-Pergakes K.L., Kennedy M.A., Lees N.D., Barbuch R., Koegel C., Bard M.
    Antimicrob. Agents Chemother. 42:1160-1167(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiERG6_CANAL
AccessioniPrimary (citable) accession number: O74198
Secondary accession number(s): Q5AJG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.