Reviewed,
UniProtKB/Swiss-Prot O74198 (ERG6_CANAL)
Last modified
May 26, 2009.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Sterol 24-C-methyltransferase EC=2.1.1.41 Alternative name(s): Delta(24)-sterol C-methyltransferase | ||||
| Gene names |
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| Organism | Candida albicans (Yeast) | ||||
| Taxonomic identifier | 5476 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 376 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. |
| Catalytic activity | S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. |
| Pathway | Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5. |
| Sequence similarities | Belongs to the methyltransferase superfamily. ERG6 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 376 | 376 | Sterol 24-C-methyltransferase | PRO_0000124789 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants." Jensen-Pergakes K.L., Kennedy M.A., Lees N.D., Barbuch R., Koegel C., Bard M. Antimicrob. Agents Chemother. 42:1160-1167(1998) [PubMed: 9593144] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314. |
Cross-references
Sequence databases | |
|---|---|
| AF031941 Genomic DNA. Translation: AAC26626.1. AACQ01000014 Genomic DNA. Translation: EAL02792.1. AACQ01000013 Genomic DNA. Translation: EAL02920.1. | |
| RefSeq | XP_721588.1. XP_721708.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3636655. 3636783. |
Organism-specific databases | |
| CGD | CAL0006397. ERG6. |
Phylogenomic databases | |
| OMA | O74198. FVKGDFM. |
Enzyme and pathway databases | |
| BRENDA | 2.1.1.41. 1124. |
Family and domain databases | |
| InterPro | IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view] |
| Pfam | PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ERG6_CANAL | ||||||||
| Accession | Primary (citable) accession number: O74198 Secondary accession number(s): Q5AJG1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Recent format changes Overview of recent format changes |

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