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O74197 (PUR6_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole carboxylase
EC=4.1.1.21
Alternative name(s):
AIR carboxylase
Short name=AIRC
Gene names
Name:ADE2
Ordered Locus Names:CAGL0K10340g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.

Sequence similarities

In the C-terminal section; belongs to the AIR carboxylase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Phosphoribosylaminoimidazole carboxylase
PRO_0000075022

Regions

Domain110 – 297188ATP-grasp
Nucleotide binding137 – 19256ATP By similarity

Experimental info

Sequence conflict477 – 4782MT → IA in AAC27548. Ref.1
Sequence conflict4911T → F in AAC27548. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O74197 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: 481BA9042F0C532A

FASTA57062,712
        10         20         30         40         50         60 
MDSRTVGILG GGQLGRMIVE AANRLNIKTL ILDAPNSPAK QITNASDHVD GSFANKEDIE 

        70         80         90        100        110        120 
ALAAKCDVMT VEIEHVDVNA LKEVQKQFPK LEIYPTPETI GLIQDKYVQK QHLVKNRIPV 

       130        140        150        160        170        180 
VPSITVENSK ESLIKTGSSL GYPFVLKSRT LAYDGRGNFV VKSEEDIEKG LEFLANRPLY 

       190        200        210        220        230        240 
AEKWASFKKE LSVMIIRSLD GRVYSYPIVE TIHKNNVCHL CYVPARVPDS VQHKAKLMAE 

       250        260        270        280        290        300 
NAIKSFPGCG IFGVEMFLLD DDSIVLNEIA PRPHNSGHYT INACVVSQFE AHLRAILDLP 

       310        320        330        340        350        360 
MPKNFTSLST NSTNAIMLNL LGDPETKDKE LQICERALNT PGASVYLYGK ESKPNRKVGH 

       370        380        390        400        410        420 
INIVCSSMKE CDKRLQFIMG LKTDPIKHSV MEILNAEEVR KPLVGVIMGS DSDLPVMSAA 

       430        440        450        460        470        480 
CKMLEQFEVP FEVTIVSAHR TPYRMNKYAS EAVSRGIKVI IAGAGGAAHL PGMVAAMTPV 

       490        500        510        520        530        540 
PVIGVPVKGS TLDGVDSLHS IVQMPRGVPV ATVAINNSTN AGILAVRMLG IHNYDYVKKM 

       550        560        570 
EEFLNKQEEE VLQKAAKLES IGYEKYLESK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF030388 Genomic DNA. Translation: AAC27548.1.
CR380957 Genomic DNA. Translation: CAG61632.1.
RefSeqXP_448669.1. XM_448669.1.

3D structure databases

ProteinModelPortalO74197.
SMRO74197. Positions 402-570.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2890129.
GenomeReviewsGene locus CAGL0K10340g in contig CR380957_GR.
KEGGcgr:CAGL0K10340g.

Phylogenomic databases

eggNOGfuNOG05150.
HOGENOMHBG516369.
OMAPLYAEKW.
OrthoDBEOG4TXG17.

Family and domain databases

InterProIPR016301. AIR_COase.
IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000031. N5-CAIR_Mutase_PurE_dom.
IPR013817. Pre-ATP_grasp.
IPR016185. PreATP-grasp-like.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
Gene3DG3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
KOK11808.
PfamPF00731. AIRC. 1 hit.
PF02222. ATP-grasp. 1 hit.
[Graphical view]
PIRSFPIRSF001340. AIR_carboxylase. 1 hit.
SMARTSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMSSF52255. AIR_carboxyl. 1 hit.
SSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR01162. PurE. 1 hit.
TIGR01161. PurK. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR6_CANGA
AccessionPrimary (citable) accession number: O74197
Secondary accession number(s): Q6FM75
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 16, 2004
Last modified: January 25, 2012
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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