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O74189

- PMT1_CANAL

UniProt

O74189 - PMT1_CANAL

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Protein

Dolichyl-phosphate-mannose--protein mannosyltransferase 1

Gene
PMT1, CaJ7.0330, CaO19.12638, CaO19.5171
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

Catalytic activityi

Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: CGD
  2. mannosyltransferase activity Source: CGD

GO - Biological processi

  1. cell-substrate adhesion Source: CGD
  2. cellular response to drug Source: CGD
  3. cellular response to neutral pH Source: CGD
  4. cellular response to starvation Source: CGD
  5. filamentous growth Source: CGD
  6. filamentous growth of a population of unicellular organisms Source: CGD
  7. filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
  8. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  9. fungal-type cell wall organization Source: CGD
  10. growth of symbiont in host Source: CGD
  11. negative regulation of proteolysis Source: CGD
  12. pathogenesis Source: CGD
  13. protein O-linked glycosylation Source: CGD
  14. protein O-linked mannosylation Source: CGD
  15. single-species biofilm formation on inanimate substrate Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.109. 1096.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT39. Glycosyltransferase Family 39.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-phosphate-mannose--protein mannosyltransferase 1 (EC:2.4.1.109)
Gene namesi
Name:PMT1
ORF Names:CaJ7.0330, CaO19.12638, CaO19.5171
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002654. PMT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Transmembranei150 – 17021Helical; Reviewed predictionAdd
BLAST
Transmembranei196 – 21621Helical; Reviewed predictionAdd
BLAST
Transmembranei226 – 24621Helical; Reviewed predictionAdd
BLAST
Transmembranei252 – 27221Helical; Reviewed predictionAdd
BLAST
Transmembranei291 – 31121Helical; Reviewed predictionAdd
BLAST
Transmembranei604 – 62421Helical; Reviewed predictionAdd
BLAST
Transmembranei643 – 66321Helical; Reviewed predictionAdd
BLAST
Transmembranei666 – 68621Helical; Reviewed predictionAdd
BLAST
Transmembranei700 – 72021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: CGD
  3. membrane Source: CGD
  4. plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877Dolichyl-phosphate-mannose--protein mannosyltransferase 1PRO_0000121498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi195 – 1951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi400 – 4001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi721 – 7211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002654.

Structurei

3D structure databases

ProteinModelPortaliO74189.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini340 – 39455MIR 1Add
BLAST
Domaini403 – 46260MIR 2Add
BLAST
Domaini472 – 52857MIR 3Add
BLAST

Sequence similaritiesi

Contains 3 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1928.
KOiK00728.
OrthoDBiEOG7BP89X.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
IPR027004. PMT1/PTM5.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PTHR10050:SF28. PTHR10050:SF28. 1 hit.
PfamiPF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74189-1 [UniParc]FASTAAdd to Basket

« Hide

MAKKPVTPAS KVAAKQAAVR SRHQEDVFTL DPLIDPIFQK GELRSYLVTE    50
PSPSVLKKRS IHTKEYWMLS SLLLIAFYVR MYNLSNPNSV VFDEVHFGGF 100
ARKYILGTFF MDVHPPLAKM LFGAVGAIGG FKGDFEFKSI GDKFPDSTPY 150
IFMRQFPALL GVGTVILCYL TLRQSGVRPI IAYITTFLLI IENSNVTISR 200
YILLDSPLIF FIAAAIYAWK KFEIQIPFTF GWYRSLLATG IALGLALSSK 250
WVGLFTVAWV GFLCIYQLWF LIGDLSVSTK KIWGHFFARG IILLGVPIAL 300
YLGFFAIHFQ LLNKEGDGGA FMSSAFRAGL QGNKIPRDIT EQVGLGSVVT 350
IRHVDTQGGY LHSHEHFYQT GSKQQQITLY PHLDSNNKWL IEPYNGTIHN 400
ETFVPLINGM KIRLKHINTG RRLHSHDEKP PVSERDWQKE CSCYGYDGFA 450
GDANDDWVVE IVNYRSQKGE AQTFVKAINT IFRLRHAMTG HYLFSSEVKL 500
PEWGFGQQEV TSASQGKRAL THWYIETNEN SILPPSEAKI INYPKLSLWQ 550
KVVESHKRMW KINQGLTSHH HWQSSPSEWP LLLRGINYWN KEHKQVYLLG 600
NAVTWWAATL SIITFGTYVL VTVFRWHLGT PLSTNKHVFN FNVQTFSYVL 650
GWALHYLPFF IMGRQLFLHH YLPALYFGIL ALGHFFEIFT GYLTSRSKYF 700
QQVAFVLVGL FSILSLVFYV NYSSLIYGTP WTKASCELTK PFSGWDYNCG 750
TFFDTLGEYD IQEKSLASES EIPTETVVVE AKQTPKAEPK LAKQDDHIES 800
PAAAEPVEEK EVKEEVEQLA PPLAVDFEEE TPKVEDPQVA DVDASSNDEK 850
SVEEKQQQEQ QQEQEQVEDE SVHQVQQ 877
Length:877
Mass (Da):99,935
Last modified:November 1, 1998 - v1
Checksum:i3B0F6ED9C96DCC16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000232 Genomic DNA. Translation: AAC31119.1.
AP006852 Genomic DNA. Translation: BAE44795.1.
AACQ01000061 Genomic DNA. Translation: EAK97943.1.
AACQ01000060 Genomic DNA. Translation: EAK98013.1.
RefSeqiXP_716926.1. XM_711833.1.
XP_716993.1. XM_711900.1.
XP_888898.1. XM_883805.1.

Genome annotation databases

GeneIDi3641393.
3641443.
3703892.
KEGGical:CaO19.12638.
cal:CaO19.5171.
cal:CaO19_5171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000232 Genomic DNA. Translation: AAC31119.1 .
AP006852 Genomic DNA. Translation: BAE44795.1 .
AACQ01000061 Genomic DNA. Translation: EAK97943.1 .
AACQ01000060 Genomic DNA. Translation: EAK98013.1 .
RefSeqi XP_716926.1. XM_711833.1.
XP_716993.1. XM_711900.1.
XP_888898.1. XM_883805.1.

3D structure databases

ProteinModelPortali O74189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0002654.

Chemistry

BindingDBi O74189.
ChEMBLi CHEMBL3534.

Protein family/group databases

CAZyi GT39. Glycosyltransferase Family 39.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3641393.
3641443.
3703892.
KEGGi cal:CaO19.12638.
cal:CaO19.5171.
cal:CaO19_5171.

Organism-specific databases

CGDi CAL0002654. PMT1.

Phylogenomic databases

eggNOGi COG1928.
KOi K00728.
OrthoDBi EOG7BP89X.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BRENDAi 2.4.1.109. 1096.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR003342. Glyco_trans_39.
IPR016093. MIR_motif.
IPR027004. PMT1/PTM5.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
PTHR10050:SF28. PTHR10050:SF28. 1 hit.
Pfami PF02815. MIR. 1 hit.
PF02366. PMT. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple functions of Pmt1p-mediated protein O-mannosylation in the fungal pathogen Candida albicans."
    Timpel C., Strahl-Bolsinger S., Ziegelbauer K., Ernst J.F.
    J. Biol. Chem. 273:20837-20846(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CAF3-1.
  2. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
    Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
    Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPMT1_CANAL
AccessioniPrimary (citable) accession number: O74189
Secondary accession number(s): Q3MP65, Q5A5A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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