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O74189

- PMT1_CANAL

UniProt

O74189 - PMT1_CANAL

Protein

Dolichyl-phosphate-mannose--protein mannosyltransferase 1

Gene

PMT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

    Catalytic activityi

    Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-phosphate-mannose-protein mannosyltransferase activity Source: CGD
    2. mannosyltransferase activity Source: CGD

    GO - Biological processi

    1. cell-substrate adhesion Source: CGD
    2. cellular response to drug Source: CGD
    3. cellular response to neutral pH Source: CGD
    4. cellular response to starvation Source: CGD
    5. filamentous growth Source: CGD
    6. filamentous growth of a population of unicellular organisms Source: CGD
    7. filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
    8. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
    9. fungal-type cell wall organization Source: CGD
    10. growth of symbiont in host Source: CGD
    11. negative regulation of proteolysis Source: CGD
    12. pathogenesis Source: CGD
    13. protein O-linked glycosylation Source: CGD
    14. protein O-linked mannosylation Source: CGD
    15. single-species biofilm formation on inanimate substrate Source: CGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.109. 1096.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT39. Glycosyltransferase Family 39.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dolichyl-phosphate-mannose--protein mannosyltransferase 1 (EC:2.4.1.109)
    Gene namesi
    Name:PMT1
    ORF Names:CaJ7.0330, CaO19.12638, CaO19.5171
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002654. PMT1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: CGD
    3. membrane Source: CGD
    4. plasma membrane Source: CGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 877877Dolichyl-phosphate-mannose--protein mannosyltransferase 1PRO_0000121498Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0002654.

    Structurei

    3D structure databases

    ProteinModelPortaliO74189.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei604 – 62421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei643 – 66321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei666 – 68621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei700 – 72021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini340 – 39455MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini403 – 46260MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 52857MIR 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyltransferase 39 family.Curated
    Contains 3 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1928.
    KOiK00728.
    OrthoDBiEOG7BP89X.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    IPR027004. PMT1/PTM5.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PTHR10050:SF28. PTHR10050:SF28. 1 hit.
    PfamiPF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view]
    SMARTiSM00472. MIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF82109. SSF82109. 1 hit.
    PROSITEiPS50919. MIR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74189-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKKPVTPAS KVAAKQAAVR SRHQEDVFTL DPLIDPIFQK GELRSYLVTE    50
    PSPSVLKKRS IHTKEYWMLS SLLLIAFYVR MYNLSNPNSV VFDEVHFGGF 100
    ARKYILGTFF MDVHPPLAKM LFGAVGAIGG FKGDFEFKSI GDKFPDSTPY 150
    IFMRQFPALL GVGTVILCYL TLRQSGVRPI IAYITTFLLI IENSNVTISR 200
    YILLDSPLIF FIAAAIYAWK KFEIQIPFTF GWYRSLLATG IALGLALSSK 250
    WVGLFTVAWV GFLCIYQLWF LIGDLSVSTK KIWGHFFARG IILLGVPIAL 300
    YLGFFAIHFQ LLNKEGDGGA FMSSAFRAGL QGNKIPRDIT EQVGLGSVVT 350
    IRHVDTQGGY LHSHEHFYQT GSKQQQITLY PHLDSNNKWL IEPYNGTIHN 400
    ETFVPLINGM KIRLKHINTG RRLHSHDEKP PVSERDWQKE CSCYGYDGFA 450
    GDANDDWVVE IVNYRSQKGE AQTFVKAINT IFRLRHAMTG HYLFSSEVKL 500
    PEWGFGQQEV TSASQGKRAL THWYIETNEN SILPPSEAKI INYPKLSLWQ 550
    KVVESHKRMW KINQGLTSHH HWQSSPSEWP LLLRGINYWN KEHKQVYLLG 600
    NAVTWWAATL SIITFGTYVL VTVFRWHLGT PLSTNKHVFN FNVQTFSYVL 650
    GWALHYLPFF IMGRQLFLHH YLPALYFGIL ALGHFFEIFT GYLTSRSKYF 700
    QQVAFVLVGL FSILSLVFYV NYSSLIYGTP WTKASCELTK PFSGWDYNCG 750
    TFFDTLGEYD IQEKSLASES EIPTETVVVE AKQTPKAEPK LAKQDDHIES 800
    PAAAEPVEEK EVKEEVEQLA PPLAVDFEEE TPKVEDPQVA DVDASSNDEK 850
    SVEEKQQQEQ QQEQEQVEDE SVHQVQQ 877
    Length:877
    Mass (Da):99,935
    Last modified:November 1, 1998 - v1
    Checksum:i3B0F6ED9C96DCC16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000232 Genomic DNA. Translation: AAC31119.1.
    AP006852 Genomic DNA. Translation: BAE44795.1.
    AACQ01000061 Genomic DNA. Translation: EAK97943.1.
    AACQ01000060 Genomic DNA. Translation: EAK98013.1.
    RefSeqiXP_716926.1. XM_711833.1.
    XP_716993.1. XM_711900.1.
    XP_888898.1. XM_883805.1.

    Genome annotation databases

    GeneIDi3641393.
    3641443.
    3703892.
    KEGGical:CaO19.12638.
    cal:CaO19.5171.
    cal:CaO19_5171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000232 Genomic DNA. Translation: AAC31119.1 .
    AP006852 Genomic DNA. Translation: BAE44795.1 .
    AACQ01000061 Genomic DNA. Translation: EAK97943.1 .
    AACQ01000060 Genomic DNA. Translation: EAK98013.1 .
    RefSeqi XP_716926.1. XM_711833.1.
    XP_716993.1. XM_711900.1.
    XP_888898.1. XM_883805.1.

    3D structure databases

    ProteinModelPortali O74189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0002654.

    Chemistry

    BindingDBi O74189.
    ChEMBLi CHEMBL3534.

    Protein family/group databases

    CAZyi GT39. Glycosyltransferase Family 39.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3641393.
    3641443.
    3703892.
    KEGGi cal:CaO19.12638.
    cal:CaO19.5171.
    cal:CaO19_5171.

    Organism-specific databases

    CGDi CAL0002654. PMT1.

    Phylogenomic databases

    eggNOGi COG1928.
    KOi K00728.
    OrthoDBi EOG7BP89X.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.1.109. 1096.

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR003342. Glyco_trans_39.
    IPR016093. MIR_motif.
    IPR027004. PMT1/PTM5.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    PTHR10050:SF28. PTHR10050:SF28. 1 hit.
    Pfami PF02815. MIR. 1 hit.
    PF02366. PMT. 1 hit.
    [Graphical view ]
    SMARTi SM00472. MIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF82109. SSF82109. 1 hit.
    PROSITEi PS50919. MIR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple functions of Pmt1p-mediated protein O-mannosylation in the fungal pathogen Candida albicans."
      Timpel C., Strahl-Bolsinger S., Ziegelbauer K., Ernst J.F.
      J. Biol. Chem. 273:20837-20846(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CAF3-1.
    2. "Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome."
      Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T., Mikami Y.
      Genetics 170:1525-1537(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPMT1_CANAL
    AccessioniPrimary (citable) accession number: O74189
    Secondary accession number(s): Q3MP65, Q5A5A9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3