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Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase (aldA)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei170Transition state stabilizerBy similarity1
Active sitei269Proton acceptorPROSITE-ProRule annotation1
Active sitei303NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 251NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Short name:
ALDDH
Short name:
ALDH
Gene namesi
Name:aldA
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564351 – 500Aldehyde dehydrogenaseAdd BLAST500

Structurei

3D structure databases

ProteinModelPortaliO74187
SMRiO74187
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

OMAiTFVQEDV

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

O74187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSIFTHQWD TPVYKGSTSI NTGLFINGEF VDGVKNTTID VVNPANGKLI
60 70 80 90 100
TKISEATEAD IDIAVEAAHK AFETTWGLNC SGSKRGDMLY KLAQLMEKNI
110 120 130 140 150
DDLSAIEALD NGKTFLWAKS VDLSLSISTI KHYAGWADKN FGQVIETDEK
160 170 180 190 200
KLTYSRHEPI GVVGQIIPWN FPLLMLAWKI GPALATGNCI VLKPSEFTPL
210 220 230 240 250
SALRMCALIQ EAGFPPGVVN VVTGYGSTTG QAISSHMKID KVAFTGSTLV
260 270 280 290 300
GRKVMEAAAK SNLKNVTLEL GGKSPVVIFD DADLEQSVNW TAHGLFWNHG
310 320 330 340 350
QACCAGTRIF VQEGIYDKFL QKFTDKIKEI KLGDPFGLGI DQGPQVSQIQ
360 370 380 390 400
YDRIMSYIES GRAEGATVHV GGERHGNEGY FIQPTIFTDT TPDMKIVKEE
410 420 430 440 450
IFGPVGAVIK FKDGKEVIKQ ANDSNYGLAA AVFSQDINKA IETAHAFKAG
460 470 480 490 500
TAWVNCANTI DAGVPFGGYK QSGIGRELGE YALHNYTNVK AVHVNLNWKM
Length:500
Mass (Da):54,395
Last modified:November 1, 1998 - v1
Checksum:iC4FCE58B50855925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17825 Genomic DNA Translation: CAA76875.1

Similar proteinsi

Entry informationi

Entry nameiALDH_AGABI
AccessioniPrimary (citable) accession number: O74187
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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