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Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei170 – 1701Transition state stabilizerBy similarity
Active sitei269 – 2691Proton acceptorPROSITE-ProRule annotation
Active sitei303 – 3031NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2516NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Short name:
ALDDH
Short name:
ALDH
Gene namesi
Name:aldA
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Aldehyde dehydrogenasePRO_0000056435Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO74187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

OMAiICEIQEA.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74187-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSIFTHQWD TPVYKGSTSI NTGLFINGEF VDGVKNTTID VVNPANGKLI
60 70 80 90 100
TKISEATEAD IDIAVEAAHK AFETTWGLNC SGSKRGDMLY KLAQLMEKNI
110 120 130 140 150
DDLSAIEALD NGKTFLWAKS VDLSLSISTI KHYAGWADKN FGQVIETDEK
160 170 180 190 200
KLTYSRHEPI GVVGQIIPWN FPLLMLAWKI GPALATGNCI VLKPSEFTPL
210 220 230 240 250
SALRMCALIQ EAGFPPGVVN VVTGYGSTTG QAISSHMKID KVAFTGSTLV
260 270 280 290 300
GRKVMEAAAK SNLKNVTLEL GGKSPVVIFD DADLEQSVNW TAHGLFWNHG
310 320 330 340 350
QACCAGTRIF VQEGIYDKFL QKFTDKIKEI KLGDPFGLGI DQGPQVSQIQ
360 370 380 390 400
YDRIMSYIES GRAEGATVHV GGERHGNEGY FIQPTIFTDT TPDMKIVKEE
410 420 430 440 450
IFGPVGAVIK FKDGKEVIKQ ANDSNYGLAA AVFSQDINKA IETAHAFKAG
460 470 480 490 500
TAWVNCANTI DAGVPFGGYK QSGIGRELGE YALHNYTNVK AVHVNLNWKM
Length:500
Mass (Da):54,395
Last modified:November 1, 1998 - v1
Checksum:iC4FCE58B50855925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17825 Genomic DNA. Translation: CAA76875.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17825 Genomic DNA. Translation: CAA76875.1.

3D structure databases

ProteinModelPortaliO74187.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OMAiICEIQEA.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular structure and spatial expression of housekeeping genes in mushrooms."
    Schaap P.J., Mueller Y., Visser J.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Horst H39.

Entry informationi

Entry nameiALDH_AGABI
AccessioniPrimary (citable) accession number: O74187
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.