Reviewed, UniProtKB/Swiss-Prot O74187 (ALDH_AGABI)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase
      Short name=ALDDH
      Short name=ALDH
    EC=1.2.1.3

Gene names

Name:

aldA

Organism

Agaricus bisporus (Common mushroom)

Taxonomic identifier

5341 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Agaricomycetidae › Agaricales › Agaricaceae › Agaricus

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Aldehyde dehydrogenase		PRO_0000056435
Regions
	Nucleotide binding	246 – 251	6	NAD By similarity
Sites
	Active site	269	1	Proton acceptor By similarity
	Active site	303	1	Nucleophile By similarity
	Site	170	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	O74187-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: C4FCE58B50855925	FASTA	500	54,395
	10 20 30 40 50 60 MPSIFTHQWD TPVYKGSTSI NTGLFINGEF VDGVKNTTID VVNPANGKLI TKISEATEAD 70 80 90 100 110 120 IDIAVEAAHK AFETTWGLNC SGSKRGDMLY KLAQLMEKNI DDLSAIEALD NGKTFLWAKS 130 140 150 160 170 180 VDLSLSISTI KHYAGWADKN FGQVIETDEK KLTYSRHEPI GVVGQIIPWN FPLLMLAWKI 190 200 210 220 230 240 GPALATGNCI VLKPSEFTPL SALRMCALIQ EAGFPPGVVN VVTGYGSTTG QAISSHMKID 250 260 270 280 290 300 KVAFTGSTLV GRKVMEAAAK SNLKNVTLEL GGKSPVVIFD DADLEQSVNW TAHGLFWNHG 310 320 330 340 350 360 QACCAGTRIF VQEGIYDKFL QKFTDKIKEI KLGDPFGLGI DQGPQVSQIQ YDRIMSYIES 370 380 390 400 410 420 GRAEGATVHV GGERHGNEGY FIQPTIFTDT TPDMKIVKEE IFGPVGAVIK FKDGKEVIKQ 430 440 450 460 470 480 ANDSNYGLAA AVFSQDINKA IETAHAFKAG TAWVNCANTI DAGVPFGGYK QSGIGRELGE 490 500 YALHNYTNVK AVHVNLNWKM

References

[1]	"Molecular structure and spatial expression of housekeeping genes in mushrooms." Schaap P.J., Mueller Y., Visser J. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Horst H39.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y17825 Genomic DNA. Translation: CAA76875.1.
3D structure databases
HSSP	HSSP built from PDB template 1BI9 based on UniProtKB Q63639.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.3. 984.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_AGABI

Accession

Primary (citable) accession number: O74187

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)