Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O74187 (ALDH_AGABI)

Last modified June 16, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aldehyde dehydrogenase
      Short name=ALDDH
      Short name=ALDH
    EC=1.2.1.3
Gene names
Name: aldA
OrganismAgaricus bisporus (Common mushroom)
Taxonomic identifier5341 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaHomobasidiomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = an acid + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Aldehyde dehydrogenase
PRO_0000056435

Regions

Nucleotide binding246 – 2516NAD By similarity

Sites

Active site2691Proton acceptor By similarity
Active site3031Nucleophile By similarity
Site1701Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
O74187-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: C4FCE58B50855925

FASTA50054,395
        10         20         30         40         50         60 
MPSIFTHQWD TPVYKGSTSI NTGLFINGEF VDGVKNTTID VVNPANGKLI TKISEATEAD 

        70         80         90        100        110        120 
IDIAVEAAHK AFETTWGLNC SGSKRGDMLY KLAQLMEKNI DDLSAIEALD NGKTFLWAKS 

       130        140        150        160        170        180 
VDLSLSISTI KHYAGWADKN FGQVIETDEK KLTYSRHEPI GVVGQIIPWN FPLLMLAWKI 

       190        200        210        220        230        240 
GPALATGNCI VLKPSEFTPL SALRMCALIQ EAGFPPGVVN VVTGYGSTTG QAISSHMKID 

       250        260        270        280        290        300 
KVAFTGSTLV GRKVMEAAAK SNLKNVTLEL GGKSPVVIFD DADLEQSVNW TAHGLFWNHG 

       310        320        330        340        350        360 
QACCAGTRIF VQEGIYDKFL QKFTDKIKEI KLGDPFGLGI DQGPQVSQIQ YDRIMSYIES 

       370        380        390        400        410        420 
GRAEGATVHV GGERHGNEGY FIQPTIFTDT TPDMKIVKEE IFGPVGAVIK FKDGKEVIKQ 

       430        440        450        460        470        480 
ANDSNYGLAA AVFSQDINKA IETAHAFKAG TAWVNCANTI DAGVPFGGYK QSGIGRELGE 

       490        500 
YALHNYTNVK AVHVNLNWKM 

« Hide

References

[1]"Molecular structure and spatial expression of housekeeping genes in mushrooms."
Schaap P.J., Mueller Y., Visser J.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Horst H39.

Cross-references

Sequence databases

Y17825 Genomic DNA. Translation: CAA76875.1.

3D structure databases

HSSPHSSP built from PDB template 1BI9 based on UniProtKB Q63639.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.2.1.3. 984.

Family and domain databases

InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_AGABI
AccessionPrimary (citable) accession number: O74187
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents