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O74187

- ALDH_AGABI

UniProt

O74187 - ALDH_AGABI

Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei170 – 1701Transition state stabilizerBy similarity
    Active sitei269 – 2691Proton acceptorPROSITE-ProRule annotation
    Active sitei303 – 3031NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 2516NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Short name:
    ALDDH
    Short name:
    ALDH
    Gene namesi
    Name:aldA
    OrganismiAgaricus bisporus (White button mushroom)
    Taxonomic identifieri5341 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Aldehyde dehydrogenasePRO_0000056435Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO74187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    OMAiWINCFNA.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view]
    PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74187-1 [UniParc]FASTAAdd to Basket

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    MPSIFTHQWD TPVYKGSTSI NTGLFINGEF VDGVKNTTID VVNPANGKLI    50
    TKISEATEAD IDIAVEAAHK AFETTWGLNC SGSKRGDMLY KLAQLMEKNI 100
    DDLSAIEALD NGKTFLWAKS VDLSLSISTI KHYAGWADKN FGQVIETDEK 150
    KLTYSRHEPI GVVGQIIPWN FPLLMLAWKI GPALATGNCI VLKPSEFTPL 200
    SALRMCALIQ EAGFPPGVVN VVTGYGSTTG QAISSHMKID KVAFTGSTLV 250
    GRKVMEAAAK SNLKNVTLEL GGKSPVVIFD DADLEQSVNW TAHGLFWNHG 300
    QACCAGTRIF VQEGIYDKFL QKFTDKIKEI KLGDPFGLGI DQGPQVSQIQ 350
    YDRIMSYIES GRAEGATVHV GGERHGNEGY FIQPTIFTDT TPDMKIVKEE 400
    IFGPVGAVIK FKDGKEVIKQ ANDSNYGLAA AVFSQDINKA IETAHAFKAG 450
    TAWVNCANTI DAGVPFGGYK QSGIGRELGE YALHNYTNVK AVHVNLNWKM 500
    Length:500
    Mass (Da):54,395
    Last modified:November 1, 1998 - v1
    Checksum:iC4FCE58B50855925
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17825 Genomic DNA. Translation: CAA76875.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17825 Genomic DNA. Translation: CAA76875.1 .

    3D structure databases

    ProteinModelPortali O74187.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OMAi WINCFNA.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view ]
    PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular structure and spatial expression of housekeeping genes in mushrooms."
      Schaap P.J., Mueller Y., Visser J.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Horst H39.

    Entry informationi

    Entry nameiALDH_AGABI
    AccessioniPrimary (citable) accession number: O74187
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3