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O74187 (ALDH_AGABI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

Short name=ALDDH
Short name=ALDH
EC=1.2.1.3
Gene names
Name:aldA
OrganismAgaricus bisporus (White button mushroom)
Taxonomic identifier5341 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Aldehyde dehydrogenase
PRO_0000056435

Regions

Nucleotide binding246 – 2516NAD By similarity

Sites

Active site2691Proton acceptor By similarity
Active site3031Nucleophile By similarity
Site1701Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
O74187 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: C4FCE58B50855925

FASTA50054,395
        10         20         30         40         50         60 
MPSIFTHQWD TPVYKGSTSI NTGLFINGEF VDGVKNTTID VVNPANGKLI TKISEATEAD 

        70         80         90        100        110        120 
IDIAVEAAHK AFETTWGLNC SGSKRGDMLY KLAQLMEKNI DDLSAIEALD NGKTFLWAKS 

       130        140        150        160        170        180 
VDLSLSISTI KHYAGWADKN FGQVIETDEK KLTYSRHEPI GVVGQIIPWN FPLLMLAWKI 

       190        200        210        220        230        240 
GPALATGNCI VLKPSEFTPL SALRMCALIQ EAGFPPGVVN VVTGYGSTTG QAISSHMKID 

       250        260        270        280        290        300 
KVAFTGSTLV GRKVMEAAAK SNLKNVTLEL GGKSPVVIFD DADLEQSVNW TAHGLFWNHG 

       310        320        330        340        350        360 
QACCAGTRIF VQEGIYDKFL QKFTDKIKEI KLGDPFGLGI DQGPQVSQIQ YDRIMSYIES 

       370        380        390        400        410        420 
GRAEGATVHV GGERHGNEGY FIQPTIFTDT TPDMKIVKEE IFGPVGAVIK FKDGKEVIKQ 

       430        440        450        460        470        480 
ANDSNYGLAA AVFSQDINKA IETAHAFKAG TAWVNCANTI DAGVPFGGYK QSGIGRELGE 

       490        500 
YALHNYTNVK AVHVNLNWKM 

« Hide

References

[1]"Molecular structure and spatial expression of housekeeping genes in mushrooms."
Schaap P.J., Mueller Y., Visser J.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Horst H39.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y17825 Genomic DNA. Translation: CAA76875.1.

3D structure databases

ProteinModelPortalO74187.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OMAWINCFNA.

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_AGABI
AccessionPrimary (citable) accession number: O74187
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways