Reviewed,
UniProtKB/Swiss-Prot O74165 (FDFT_PICJA)
Last modified
October 13, 2009.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Squalene synthetase Short name=SQS Short name=SS EC=2.5.1.21 Alternative name(s): Farnesyl-diphosphate farnesyltransferase FPP:FPP farnesyltransferase | ||
| Gene names |
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| Organism | Pichia jadinii (Yeast) (Candida utilis) | ||
| Taxonomic identifier | 4903 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Pichia |
Protein attributes
| Sequence length | 443 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. Presqualene diphosphate + NAD(P)H = squalene + diphosphate + NAD(P)+. |
| Cofactor | Magnesium. |
| Pathway | Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the phytoene/squalene synthetase family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "Increased carotenoid production by the food yeast Candida utilis through metabolic engineering of the isoprenoid pathway." Shimada H., Kondo K., Fraser P.D., Miura Y., Saito T., Misawa N. Appl. Environ. Microbiol. 64:2676-2680(1998) [PubMed: 9647847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AB012604 Genomic DNA. Translation: BAA31938.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EZF based on UniProtKB P37268. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.21. 288941. |
Family and domain databases | |
| InterPro | IPR002060. Squ/phyt_synthse. IPR006449. Squal_synth. IPR019845. Squalene/phytoene_synthase_CS. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| Pfam | PF00494. SQS_PSY. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01559. squal_synth. 1 hit. |
| PROSITE | PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit. PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FDFT_PICJA | ||||||||
| Accession | Primary (citable) accession number: O74165 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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