Reviewed, UniProtKB/Swiss-Prot O74137 (EPD2_CANMA)

Names and origin

Protein names

Recommended name:
    Protein EPD2
Alternative name(s):
    Essential for pseudohyphal development 2

Gene names

Name:

EPD2

Organism

Candida maltosa (Yeast)

Taxonomic identifier

5479 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Sequence similarities	Belongs to the glycosyl hydrolase 72 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – ?		Protein EPD2		PRO_0000010489
	Propeptide	? – 549		Removed in mature form Potential		PRO_0000010490
Regions
	Compositional bias	440 – 520	81	Ser-rich
Amino acid modifications
	Glycosylation	41	1	N-linked (GlcNAc...) Potential
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Glycosylation	261	1	N-linked (GlcNAc...) Potential
	Glycosylation	467	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O74137-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: CAAF5B47E43CD390	FASTA	549	60,094
	10 20 30 40 50 60 MISVIKSLLT LSVLSTLAAA KFESATPPIE VVGNKFYYSN NGTQFLLRGI AYQQDTSGSV 70 80 90 100 110 120 SNGYDSDPNR KYNDPLADAD ACKRDVQYFI DTNTNTLRVY GIDPDKDHEE CMKIFSDAGI 130 140 150 160 170 180 YVIADLSEPT VSVNRINPEW NLDLYERYTK VIDNMQEYSN VLGFFAGNEV TNNRTNTDAS 190 200 210 220 230 240 PFVKAAVRDM KKYIKDNDYR TIPVGYSSND DEDTRVAIAD YFACGSLDDR ADFFGINMYE 250 260 270 280 290 300 WCGRSTFATS GYKDRTEDFK NLTIPIFFSE YGCNEVSPRV FQEVGTLYSD QMTDVWSGGI 310 320 330 340 350 360 VYMYYEEANH YGLVSLNGDR VSTLADYNNY KSAIKSISPS LARRSTIQSE DSTKTMACPD 370 380 390 400 410 420 NSHSTWRAST ELPPTPDEEF CDCISQSFNC VVADDVDAED YSTLFGEVCG YIDCGDISAN 430 440 450 460 470 480 GNTGEYGGFS FCSDKDRLSY VLNQYYHDQN ERADACDFAG SASINDNASA STSCSAAGGR 490 500 510 520 530 540 GLQSGRRSST TRGGSSSSRS SSSSSSSSTG SGSSNAGIKV GGGQMSTVKL ITITTIVTAF VGGLSIIFY

References

[1]

"Cloning and characterization of EPD2, a gene required for efficient pseudohyphal formation of a dimorphic yeast, Candida maltosa." Nakazawa T., Takahashi M., Horiuchi H., Ohta A., Takagi M. Biosci. Biotechnol. Biochem. 64:369-377(2000) [PubMed: 10737195] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 28140 / CBS 5611 / IAM 12247 / IFO 1977 / JCM 1504.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB011286 Genomic DNA. Translation: BAA32730.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	CBM43. Carbohydrate-Binding Module Family 43. GH72. Glycoside Hydrolase Family 72.
Family and domain databases
InterPro	IPR004886. GAS1. IPR012946. X8. [Graphical view]
Pfam	PF03198. Glyco_hydro_72. 1 hit. PF07983. X8. 1 hit. [Graphical view]
SMART	SM00768. X8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EPD2_CANMA

Accession

Primary (citable) accession number: O74137

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)