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O74137 (EPD2_CANMA) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein EPD2
Alternative name(s):
Essential for pseudohyphal development 2
Gene names
Name:EPD2
OrganismCandida maltosa (Yeast)
Taxonomic identifier5479 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor Potential.

Sequence similarities

Belongs to the glycosyl hydrolase 72 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
   PTMGPI-anchor
Glycoprotein
Lipoprotein
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentanchored to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

cation binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – ?Protein EPD2PRO_0000010489
Propeptide? – 549Removed in mature form PotentialPRO_0000010490

Regions

Compositional bias440 – 52081Ser-rich

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation4671N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O74137 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: CAAF5B47E43CD390

FASTA54960,094
        10         20         30         40         50         60 
MISVIKSLLT LSVLSTLAAA KFESATPPIE VVGNKFYYSN NGTQFLLRGI AYQQDTSGSV 

        70         80         90        100        110        120 
SNGYDSDPNR KYNDPLADAD ACKRDVQYFI DTNTNTLRVY GIDPDKDHEE CMKIFSDAGI 

       130        140        150        160        170        180 
YVIADLSEPT VSVNRINPEW NLDLYERYTK VIDNMQEYSN VLGFFAGNEV TNNRTNTDAS 

       190        200        210        220        230        240 
PFVKAAVRDM KKYIKDNDYR TIPVGYSSND DEDTRVAIAD YFACGSLDDR ADFFGINMYE 

       250        260        270        280        290        300 
WCGRSTFATS GYKDRTEDFK NLTIPIFFSE YGCNEVSPRV FQEVGTLYSD QMTDVWSGGI 

       310        320        330        340        350        360 
VYMYYEEANH YGLVSLNGDR VSTLADYNNY KSAIKSISPS LARRSTIQSE DSTKTMACPD 

       370        380        390        400        410        420 
NSHSTWRAST ELPPTPDEEF CDCISQSFNC VVADDVDAED YSTLFGEVCG YIDCGDISAN 

       430        440        450        460        470        480 
GNTGEYGGFS FCSDKDRLSY VLNQYYHDQN ERADACDFAG SASINDNASA STSCSAAGGR 

       490        500        510        520        530        540 
GLQSGRRSST TRGGSSSSRS SSSSSSSSTG SGSSNAGIKV GGGQMSTVKL ITITTIVTAF 


VGGLSIIFY

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References

[1]"Cloning and characterization of EPD2, a gene required for efficient pseudohyphal formation of a dimorphic yeast, Candida maltosa."
Nakazawa T., Takahashi M., Horiuchi H., Ohta A., Takagi M.
Biosci. Biotechnol. Biochem. 64:369-377(2000) [PubMed: 10737195] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 28140 / CBS 5611 / IAM 12247 / JCM 1504 / NBRC 1977.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB011286 Genomic DNA. Translation: BAA32730.1.

3D structure databases

ProteinModelPortalO74137.
ModBaseSearch...

Protein family/group databases

CAZyCBM43. Carbohydrate-Binding Module Family 43.
GH72. Glycoside Hydrolase Family 72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004886. GAS1.
IPR013781. Glyco_hydro_subgr_catalytic.
IPR017853. Glycoside_hydrolase_SF.
IPR012946. X8.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PfamPF03198. Glyco_hydro_72. 1 hit.
PF07983. X8. 1 hit.
[Graphical view]
SMARTSM00768. X8. 1 hit.
[Graphical view]
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEPD2_CANMA
AccessionPrimary (citable) accession number: O74137
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 21, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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