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Protein

Cell division control protein 45 homolog

Gene

sna41

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for initiation of chromosomal DNA replication. May have a role in regulating the MCM proteins nda1 and nda4.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Enzyme and pathway databases

ReactomeiR-SPO-113510. E2F mediated regulation of DNA replication.
R-SPO-68962. Activation of the pre-replicative complex.
R-SPO-69205. G1/S-Specific Transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 45 homolog
Alternative name(s):
Suppressor of nda4 protein
Gene namesi
Name:sna41
ORF Names:SPAC17D4.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17D4.02.
PomBaseiSPAC17D4.02.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • cytosol Source: PomBase
  • DNA replication preinitiation complex Source: GO_Central
  • nuclear chromatin Source: PomBase
  • nuclear pre-replicative complex Source: GO_Central
  • nuclear replication fork Source: PomBase
  • nucleus Source: PomBase
  • replication fork protection complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Cell division control protein 45 homologPRO_0000192818Add
BLAST

Proteomic databases

MaxQBiO74113.

Interactioni

Subunit structurei

Interacts with sld3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
sld3Q097612EBI-1559427,EBI-1559416

Protein-protein interaction databases

BioGridi278735. 23 interactions.
IntActiO74113. 3 interactions.
MINTiMINT-4677978.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC45 family.Curated

Phylogenomic databases

HOGENOMiHOG000204377.
InParanoidiO74113.
KOiK06628.
OMAiDALCACR.
OrthoDBiEOG7H4F3M.
PhylomeDBiO74113.

Family and domain databases

InterProiIPR003874. CDC45.
[Graphical view]
PANTHERiPTHR10507. PTHR10507. 1 hit.
PfamiPF02724. CDC45. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIKRSDYAS AYLKIKEASV SGGCTVQLFV ALDPDALCAC KLLSTLLKGD
60 70 80 90 100
FISHKIRPVS GYRDLEQANK TLLEQNEDIK FIILLNCGTM VDLNNYLVSM
110 120 130 140 150
EDVSIYVIDS HRPHNLNNIY IENNIFVFDD GDIEEDMNKI HDAWYAFNSH
160 170 180 190 200
ELSDEENSDS SNEREEEVED DNRSVESYSS SDYQARSRRR FSEETTQRRA
210 220 230 240 250
EIKEKRKKRK EFASILSEYY EKGSWYGESI TNILFAVASM LGREDNDMLW
260 270 280 290 300
LAIVGLTCLE IHCQSSKKYF NRSYSLLKDE VNRLNPSPLE NQIVGRAHGK
310 320 330 340 350
TPHDQSIRLE DEFRFMLVRH WSLYDSMLHS AYVGSRLHIW SEEGRKRLHK
360 370 380 390 400
LLAKMGLSLV ECKQTYIHMN MDLKKTLKSS LKRFAPFYGL DDVIFHSFTR
410 420 430 440 450
TYGFKCTLSA SDVSYAISAL LEMGNTGVLL QSKTVARSPD MTEEEYLEKF
460 470 480 490 500
ENAQNQEWLH NFYDAYDALD DVDSLERALK LAMHLQRAIV RTGITLLEKR
510 520 530 540 550
AIKTLRSFRF GLINEGPDLK IFMHPLALTK MSLWIAEAIN EQEREFGKLR
560 570 580 590 600
HLPLVLAAFV EEKNRYLIVG TSTSAFTSNE DDDDDDGHGH NRFGVAFQEV
610 620 630
ANMTSATLQM DCFEASVIEC QKSDLGVFLE SLSFKTLL
Length:638
Mass (Da):73,379
Last modified:November 1, 1998 - v1
Checksum:iAE537DE856AF61B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001739 Genomic DNA. Translation: BAA28947.1.
CU329670 Genomic DNA. Translation: CAC05732.1.
PIRiT43018.
RefSeqiNP_594693.1. NM_001020121.2.

Genome annotation databases

EnsemblFungiiSPAC17D4.02.1; SPAC17D4.02.1:pep; SPAC17D4.02.
GeneIDi2542266.
KEGGispo:SPAC17D4.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001739 Genomic DNA. Translation: BAA28947.1.
CU329670 Genomic DNA. Translation: CAC05732.1.
PIRiT43018.
RefSeqiNP_594693.1. NM_001020121.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278735. 23 interactions.
IntActiO74113. 3 interactions.
MINTiMINT-4677978.

Proteomic databases

MaxQBiO74113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC17D4.02.1; SPAC17D4.02.1:pep; SPAC17D4.02.
GeneIDi2542266.
KEGGispo:SPAC17D4.02.

Organism-specific databases

EuPathDBiFungiDB:SPAC17D4.02.
PomBaseiSPAC17D4.02.

Phylogenomic databases

HOGENOMiHOG000204377.
InParanoidiO74113.
KOiK06628.
OMAiDALCACR.
OrthoDBiEOG7H4F3M.
PhylomeDBiO74113.

Enzyme and pathway databases

ReactomeiR-SPO-113510. E2F mediated regulation of DNA replication.
R-SPO-68962. Activation of the pre-replicative complex.
R-SPO-69205. G1/S-Specific Transcription.

Miscellaneous databases

PROiO74113.

Family and domain databases

InterProiIPR003874. CDC45.
[Graphical view]
PANTHERiPTHR10507. PTHR10507. 1 hit.
PfamiPF02724. CDC45. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of sna41 gene, which is the suppressor of nda4 mutation and is involved in DNA replication in Schizosaccharomyces pombe."
    Miyake S., Yamashita S.
    Genes Cells 3:157-166(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast."
    Nakajima R., Masukata H.
    Mol. Biol. Cell 13:1462-1472(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLD3.

Entry informationi

Entry nameiCDC45_SCHPO
AccessioniPrimary (citable) accession number: O74113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.