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O74110 (PYRF_THEAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:Ta0073
OrganismThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) [Reference proteome] [HAMAP]
Taxonomic identifier273075 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Ref.1

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Sequence caution

The sequence CAC11221.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134620

Regions

Region59 – 6810Substrate binding By similarity
Region164 – 17411Substrate binding By similarity

Sites

Active site611Proton donor By similarity
Binding site111Substrate By similarity
Binding site331Substrate By similarity
Binding site1141Substrate By similarity
Binding site1871Substrate; via amide nitrogen By similarity
Binding site1881Substrate By similarity

Experimental info

Sequence conflict2061E → G in AAC24044. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O74110 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 1171F2C6AC058489

FASTA21422,890
        10         20         30         40         50         60 
MSESRLVVAL DLTDKDRALE IARSIGRQVF AIKINWPLVL AGSGSIIGEI ARVSRVVCDF 

        70         80         90        100        110        120 
KIADIPNTNS IIAKFARDQG AWGIISHSFT GLESLRSVVE ASGDTKVFSV VAMSHPGSDL 

       130        140        150        160        170        180 
INDNYRKLMD ISERAGVYGY IAPGNKLSDL SEIRKRTKKT IMSPGIGSQG GRASDAIKAG 

       190        200        210 
ADLVIVGRSI YESADPVTAA EAINEEIAKA VEQN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of ftsZ and pyrF from the archaeon Thermoplasma acidophilum."
Yaoi T., Laksanalamai P., Jiemjit A., Kagawa H., Alton T., Trent J.D.
Biochem. Biophys. Res. Commun. 275:936-945(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038845 Genomic DNA. Translation: AAC24044.1.
AL445063 Genomic DNA. Translation: CAC11221.1. Different initiation.
PIRT37332.
RefSeqNP_393552.1. NC_002578.1.

3D structure databases

ProteinModelPortalO74110.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273075.Ta0073.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC11221; CAC11221; CAC11221.
GeneID1455733.
KEGGtac:Ta0073.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226069.
KOK01591.
OMATEMSHPG.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_A. OMPdecase_type1_A.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_THEAC
AccessionPrimary (citable) accession number: O74110
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways