O74038 (GSA2_CENSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 2
Short name=GSA 2
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 2
Short name=GSA-AT 2

Gene names

Name:	hemL2
Synonyms:	gsaT
Ordered Locus Names:	CENSYa_1168

Organism

Cenarchaeum symbiosum (strain A) [Reference proteome] [HAMAP]

Taxonomic identifier

414004 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Thaumarchaeota › Cenarchaeales › Cenarchaeaceae › Cenarchaeum › Cenarchaeum symbiosum

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Glutamate-1-semialdehyde 2,1-aminomutase 2 HAMAP-Rule MF_00375		PRO_0000120478
Amino acid modifications
	Modified residue	267	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O74038 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: D1ED70D39A25CA50	FASTA	434	46,714
	10 20 30 40 50 60 MDLEREYRAK TGGSARIFAR SKKYHVGGVS HNIRFYEPYP FVTRSASGKH LVDVDGNKYV 70 80 90 100 110 120 DYWMGHWSLI LGHAPAPVRS AVEGQLRRGW IHGTVNEQTM NLSEIIRGAV SVAEKTRYVT 130 140 150 160 170 180 SGTEAVMYAA RLARAHTGRK IIAKADGGWH GYASGLLKSV NWPYDVPESG GLVDEEHSIS 190 200 210 220 230 240 IPYNDLEGSL DVLGRAGDDL ACVIIEPLLG GGGCIPADED YLRGIQEFVH SRGALLVLDE 250 260 270 280 290 300 IVTGFRFRFG CAYAAAGLDP DIVALGKIVG GGFPIGVICG KDEVMEISNT ISHAKSDRAY 310 320 330 340 350 360 IGGGTFSANP ATMTAGAAAL GELKKRKGTI YPRINSMGDD ARDKLSKIFG NRVSVTGRGS 370 380 390 400 410 420 LFMTHFVQDG AGRVSNAADA AACDVELLHR YHLDMITRDG IFFLPGKLGA ISAAHSKADL 430 KTMYSASERF AEGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic analysis reveals chromosomal variation in natural populations of the uncultured psychrophilic archaeon Cenarchaeum symbiosum." Schleper C., Delong E.F., Preston C.M., Feldman R.A., Wu K.-Y., Swanson R.V. J. Bacteriol. 180:5003-5009(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A.
[2]	"Genomic analysis of the uncultivated marine crenarchaeote Cenarchaeum symbiosum." Hallam S.J., Konstantinidis K.T., Putnam N., Schleper C., Watanabe Y., Sugahara J., Preston C., de la Torre J., Richardson P.M., DeLong E.F. Proc. Natl. Acad. Sci. U.S.A. 103:18296-18301(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF083071 Genomic DNA. Translation: AAC62681.1. DP000238 Genomic DNA. Translation: ABK77793.1.
RefSeq	YP_876097.1. NC_014820.1.
3D structure databases
ProteinModelPortal	O74038.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK77793; ABK77793; CENSYa_1168.
GeneID	6371348.
KEGG	csy:CENSYa_1168.
Phylogenomic databases
HOGENOM	HOG000020210.
KO	K01845.
OMA	TGFRFRF.
Enzyme and pathway databases
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3. Divergent sequence.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA2_CENSY

Accession

Primary (citable) accession number: O74038
Secondary accession number(s): A0RWS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program