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O74038

- GSA2_CENSY

UniProt

O74038 - GSA2_CENSY

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase 2

Gene

hemL2

Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 2 (EC:5.4.3.8)
Short name:
GSA 2
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 2
Short name:
GSA-AT 2
Gene namesi
Name:hemL2
Synonyms:gsaT
Ordered Locus Names:CENSYa_1168
OrganismiCenarchaeum symbiosum (strain A)
Taxonomic identifieri414004 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
ProteomesiUP000000758: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Glutamate-1-semialdehyde 2,1-aminomutase 2PRO_0000120478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineBy similarity

Structurei

3D structure databases

ProteinModelPortaliO74038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020210.
KOiK01845.
OMAiEVITFRN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74038-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLEREYRAK TGGSARIFAR SKKYHVGGVS HNIRFYEPYP FVTRSASGKH
60 70 80 90 100
LVDVDGNKYV DYWMGHWSLI LGHAPAPVRS AVEGQLRRGW IHGTVNEQTM
110 120 130 140 150
NLSEIIRGAV SVAEKTRYVT SGTEAVMYAA RLARAHTGRK IIAKADGGWH
160 170 180 190 200
GYASGLLKSV NWPYDVPESG GLVDEEHSIS IPYNDLEGSL DVLGRAGDDL
210 220 230 240 250
ACVIIEPLLG GGGCIPADED YLRGIQEFVH SRGALLVLDE IVTGFRFRFG
260 270 280 290 300
CAYAAAGLDP DIVALGKIVG GGFPIGVICG KDEVMEISNT ISHAKSDRAY
310 320 330 340 350
IGGGTFSANP ATMTAGAAAL GELKKRKGTI YPRINSMGDD ARDKLSKIFG
360 370 380 390 400
NRVSVTGRGS LFMTHFVQDG AGRVSNAADA AACDVELLHR YHLDMITRDG
410 420 430
IFFLPGKLGA ISAAHSKADL KTMYSASERF AEGL
Length:434
Mass (Da):46,714
Last modified:November 1, 1998 - v1
Checksum:iD1ED70D39A25CA50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083071 Genomic DNA. Translation: AAC62681.1.
DP000238 Genomic DNA. Translation: ABK77793.1.
RefSeqiWP_013482419.1. NC_014820.1.
YP_876097.1. NC_014820.1.

Genome annotation databases

EnsemblBacteriaiABK77793; ABK77793; CENSYa_1168.
GeneIDi6371348.
KEGGicsy:CENSYa_1168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083071 Genomic DNA. Translation: AAC62681.1 .
DP000238 Genomic DNA. Translation: ABK77793.1 .
RefSeqi WP_013482419.1. NC_014820.1.
YP_876097.1. NC_014820.1.

3D structure databases

ProteinModelPortali O74038.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK77793 ; ABK77793 ; CENSYa_1168 .
GeneIDi 6371348.
KEGGi csy:CENSYa_1168.

Phylogenomic databases

HOGENOMi HOG000020210.
KOi K01845.
OMAi EVITFRN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProi IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic analysis reveals chromosomal variation in natural populations of the uncultured psychrophilic archaeon Cenarchaeum symbiosum."
    Schleper C., Delong E.F., Preston C.M., Feldman R.A., Wu K.-Y., Swanson R.V.
    J. Bacteriol. 180:5003-5009(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A.

Entry informationi

Entry nameiGSA2_CENSY
AccessioniPrimary (citable) accession number: O74038
Secondary accession number(s): A0RWS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3