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O74038

- GSA2_CENSY

UniProt

O74038 - GSA2_CENSY

Protein

Glutamate-1-semialdehyde 2,1-aminomutase 2

Gene

hemL2

Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase 2 (EC:5.4.3.8)
    Short name:
    GSA 2
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase 2
    Short name:
    GSA-AT 2
    Gene namesi
    Name:hemL2
    Synonyms:gsaT
    Ordered Locus Names:CENSYa_1168
    OrganismiCenarchaeum symbiosum (strain A)
    Taxonomic identifieri414004 [NCBI]
    Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
    ProteomesiUP000000758: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Glutamate-1-semialdehyde 2,1-aminomutase 2PRO_0000120478Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO74038.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiEVITFRN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProiIPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLEREYRAK TGGSARIFAR SKKYHVGGVS HNIRFYEPYP FVTRSASGKH    50
    LVDVDGNKYV DYWMGHWSLI LGHAPAPVRS AVEGQLRRGW IHGTVNEQTM 100
    NLSEIIRGAV SVAEKTRYVT SGTEAVMYAA RLARAHTGRK IIAKADGGWH 150
    GYASGLLKSV NWPYDVPESG GLVDEEHSIS IPYNDLEGSL DVLGRAGDDL 200
    ACVIIEPLLG GGGCIPADED YLRGIQEFVH SRGALLVLDE IVTGFRFRFG 250
    CAYAAAGLDP DIVALGKIVG GGFPIGVICG KDEVMEISNT ISHAKSDRAY 300
    IGGGTFSANP ATMTAGAAAL GELKKRKGTI YPRINSMGDD ARDKLSKIFG 350
    NRVSVTGRGS LFMTHFVQDG AGRVSNAADA AACDVELLHR YHLDMITRDG 400
    IFFLPGKLGA ISAAHSKADL KTMYSASERF AEGL 434
    Length:434
    Mass (Da):46,714
    Last modified:November 1, 1998 - v1
    Checksum:iD1ED70D39A25CA50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083071 Genomic DNA. Translation: AAC62681.1.
    DP000238 Genomic DNA. Translation: ABK77793.1.
    RefSeqiWP_013482419.1. NC_014820.1.
    YP_876097.1. NC_014820.1.

    Genome annotation databases

    EnsemblBacteriaiABK77793; ABK77793; CENSYa_1168.
    GeneIDi6371348.
    KEGGicsy:CENSYa_1168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083071 Genomic DNA. Translation: AAC62681.1 .
    DP000238 Genomic DNA. Translation: ABK77793.1 .
    RefSeqi WP_013482419.1. NC_014820.1.
    YP_876097.1. NC_014820.1.

    3D structure databases

    ProteinModelPortali O74038.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK77793 ; ABK77793 ; CENSYa_1168 .
    GeneIDi 6371348.
    KEGGi csy:CENSYa_1168.

    Phylogenomic databases

    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi EVITFRN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProi IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis reveals chromosomal variation in natural populations of the uncultured psychrophilic archaeon Cenarchaeum symbiosum."
      Schleper C., Delong E.F., Preston C.M., Feldman R.A., Wu K.-Y., Swanson R.V.
      J. Bacteriol. 180:5003-5009(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A.

    Entry informationi

    Entry nameiGSA2_CENSY
    AccessioniPrimary (citable) accession number: O74038
    Secondary accession number(s): A0RWS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3