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O74036

- RADA_PYRFU

UniProt

O74036 - RADA_PYRFU

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Protein
DNA repair and recombination protein RadA
Gene
radA, PF1926
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi138 – 1458ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA-dependent ATPase activity Source: UniProtKB-HAMAP
  3. damaged DNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RadA
Gene namesi
Name:radA
Ordered Locus Names:PF1926
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349DNA repair and recombination protein RadAUniRule annotation
PRO_0000150104Add
BLAST

Proteomic databases

PRIDEiO74036.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1926.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi45 – 528
Turni53 – 553
Helixi59 – 635
Helixi67 – 748
Helixi78 – 9114
Helixi100 – 1089
Helixi118 – 1236
Turni124 – 1263
Beta strandi127 – 13913
Helixi144 – 15411
Helixi159 – 1613
Beta strandi167 – 1759
Helixi179 – 18810
Helixi193 – 1986
Beta strandi200 – 2045
Helixi208 – 22518
Beta strandi228 – 2303
Beta strandi232 – 2387
Helixi242 – 2476
Helixi253 – 27523
Beta strandi278 – 2847
Beta strandi310 – 3178
Helixi319 – 3213
Beta strandi322 – 3298
Beta strandi331 – 3333
Beta strandi338 – 3436
Beta strandi346 – 3483

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZNX-ray2.85A/B/C/D/E/F/G1-349[»]
4A6PX-ray1.50A108-349[»]
4A6XX-ray1.55A/B108-349[»]
4A74X-ray1.48A/B108-349[»]
4A7OX-ray1.88A108-349[»]
4B2IX-ray1.30A108-349[»]
4B2LX-ray1.50A108-349[»]
4B2PX-ray1.60A108-349[»]
4B32X-ray1.50A108-349[»]
4B33X-ray1.50A108-349[»]
4B34X-ray1.55A108-349[»]
4B35X-ray1.40A108-349[»]
4B3BX-ray1.19A108-349[»]
4B3CX-ray1.90A108-349[»]
4B3DX-ray1.59A/C108-349[»]
ProteinModelPortaliO74036.
SMRiO74036. Positions 35-349.

Miscellaneous databases

EvolutionaryTraceiO74036.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0468.
HOGENOMiHOG000227426.
KOiK04483.
OMAiRAYNSDM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74036-1 [UniParc]FASTAAdd to Basket

« Hide

MAGEEVKEID EFEELGFEPA TEETPKKKKK EKIIRSIEDL PGVGPATAEK    50
LREAGYDTLE AIAVASPIEL KEVAGISEGT ALKIIQAARK AANLGTFMRA 100
DEYLKKRATI GRISTGSKSL DKLLGGGIET QAITEVFGEF GSGKTQLAHT 150
LAVMVQLPPE EGGLNGSVIW IDTENTFRPE RIREIAQNRG LDPDEVLKHI 200
YVARAFNSNH QMLLVQQAED KIKELLNTDR PVKLLIVDSL TSHFRSEYIG 250
RGALAERQQK LAKHLADLHR LANLYDIAVF VTNQVQARPD AFFGDPTRPI 300
GGHILAHSAT LRVYLRKGKG GKRIARLIDA PHLPEGEAVF SITEKGIED 349
Length:349
Mass (Da):38,399
Last modified:November 1, 1998 - v1
Checksum:i726E9DF1D67AB039
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052597 Genomic DNA. Translation: AAC34998.1.
AE009950 Genomic DNA. Translation: AAL82050.1.
RefSeqiNP_579655.1. NC_003413.1.
WP_011013066.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL82050; AAL82050; PF1926.
GeneIDi1469806.
KEGGipfu:PF1926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052597 Genomic DNA. Translation: AAC34998.1 .
AE009950 Genomic DNA. Translation: AAL82050.1 .
RefSeqi NP_579655.1. NC_003413.1.
WP_011013066.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PZN X-ray 2.85 A/B/C/D/E/F/G 1-349 [» ]
4A6P X-ray 1.50 A 108-349 [» ]
4A6X X-ray 1.55 A/B 108-349 [» ]
4A74 X-ray 1.48 A/B 108-349 [» ]
4A7O X-ray 1.88 A 108-349 [» ]
4B2I X-ray 1.30 A 108-349 [» ]
4B2L X-ray 1.50 A 108-349 [» ]
4B2P X-ray 1.60 A 108-349 [» ]
4B32 X-ray 1.50 A 108-349 [» ]
4B33 X-ray 1.50 A 108-349 [» ]
4B34 X-ray 1.55 A 108-349 [» ]
4B35 X-ray 1.40 A 108-349 [» ]
4B3B X-ray 1.19 A 108-349 [» ]
4B3C X-ray 1.90 A 108-349 [» ]
4B3D X-ray 1.59 A/C 108-349 [» ]
ProteinModelPortali O74036.
SMRi O74036. Positions 35-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF1926.

Proteomic databases

PRIDEi O74036.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL82050 ; AAL82050 ; PF1926 .
GeneIDi 1469806.
KEGGi pfu:PF1926.

Phylogenomic databases

eggNOGi COG0468.
HOGENOMi HOG000227426.
KOi K04483.
OMAi RAYNSDM.

Miscellaneous databases

EvolutionaryTracei O74036.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00348. RadA.
InterProi IPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view ]
Pfami PF08423. Rad51. 1 hit.
[Graphical view ]
PIRSFi PIRSF005856. Rad51. 1 hit.
SMARTi SM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR02236. recomb_radA. 1 hit.
PROSITEi PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA repair systems in archaea: mementos from the last universal common ancestor?"
    DiRuggiero J., Brown J.R., Bogert A.P., Robb F.T.
    J. Mol. Evol. 49:474-484(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  3. "Both RadA and RadB are involved in homologous recombination in Pyrococcus furiosus."
    Komori K., Miyata T., DiRuggiero J., Holley-Shanks R., Hayashi I., Cann I.K.O., Mayanagi K., Shinagawa H., Ishino Y.
    J. Biol. Chem. 275:33782-33790(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiRADA_PYRFU
AccessioniPrimary (citable) accession number: O74036
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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