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Protein

DNA repair and recombination protein RadA

Gene

radA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi138 – 145ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.B7. 5243.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RadA
Gene namesi
Name:radA
Ordered Locus Names:PF1926
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001501041 – 349DNA repair and recombination protein RadAAdd BLAST349

Proteomic databases

PRIDEiO74036.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1926.

Chemistry databases

BindingDBiO74036.

Structurei

Secondary structure

1349
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 52Combined sources8
Turni53 – 55Combined sources3
Helixi59 – 63Combined sources5
Helixi67 – 74Combined sources8
Helixi78 – 91Combined sources14
Helixi100 – 108Combined sources9
Helixi118 – 123Combined sources6
Turni124 – 126Combined sources3
Beta strandi127 – 139Combined sources13
Helixi144 – 154Combined sources11
Helixi159 – 161Combined sources3
Beta strandi167 – 175Combined sources9
Helixi179 – 188Combined sources10
Helixi193 – 198Combined sources6
Beta strandi200 – 204Combined sources5
Helixi208 – 225Combined sources18
Beta strandi228 – 230Combined sources3
Beta strandi232 – 238Combined sources7
Helixi242 – 247Combined sources6
Helixi253 – 275Combined sources23
Beta strandi278 – 284Combined sources7
Beta strandi310 – 317Combined sources8
Helixi319 – 321Combined sources3
Beta strandi323 – 329Combined sources7
Beta strandi331 – 333Combined sources3
Beta strandi338 – 343Combined sources6
Beta strandi346 – 348Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PZNX-ray2.85A/B/C/D/E/F/G1-349[»]
4A6PX-ray1.50A108-349[»]
4A6XX-ray1.55A/B108-349[»]
4B2IX-ray1.30A108-349[»]
4B2LX-ray1.50A108-349[»]
4B2PX-ray1.60A108-349[»]
4B32X-ray1.50A108-349[»]
4B33X-ray1.50A108-349[»]
4B34X-ray1.55A108-349[»]
4B35X-ray1.40A108-349[»]
4B3BX-ray1.19A108-349[»]
4B3CX-ray1.90A108-349[»]
4B3DX-ray1.59A/C108-349[»]
4D6PX-ray1.48A/B108-349[»]
4UQOX-ray1.88A/B108-349[»]
5FOSX-ray1.35A108-349[»]
C93-108[»]
5FOTX-ray1.19A108-349[»]
5FOUX-ray1.50A108-349[»]
5FOVX-ray1.74A/C108-349[»]
5FOWX-ray1.80A/C108-349[»]
5FOXX-ray1.30A108-349[»]
5FPKX-ray1.34A108-349[»]
5J4HX-ray1.37A108-349[»]
5J4LX-ray1.13A108-349[»]
5JECX-ray2.34A/B108-349[»]
5JEDX-ray1.33A108-349[»]
5JEEX-ray1.49A108-349[»]
5KDDX-ray1.99A/B108-349[»]
5L8VX-ray1.50A108-349[»]
5LB2X-ray2.10A108-349[»]
5LB4X-ray1.98A108-349[»]
ProteinModelPortaliO74036.
SMRiO74036.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO74036.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.
HOGENOMiHOG000227426.
KOiK04483.
OMAiCQLPIDQ.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEEVKEID EFEELGFEPA TEETPKKKKK EKIIRSIEDL PGVGPATAEK
60 70 80 90 100
LREAGYDTLE AIAVASPIEL KEVAGISEGT ALKIIQAARK AANLGTFMRA
110 120 130 140 150
DEYLKKRATI GRISTGSKSL DKLLGGGIET QAITEVFGEF GSGKTQLAHT
160 170 180 190 200
LAVMVQLPPE EGGLNGSVIW IDTENTFRPE RIREIAQNRG LDPDEVLKHI
210 220 230 240 250
YVARAFNSNH QMLLVQQAED KIKELLNTDR PVKLLIVDSL TSHFRSEYIG
260 270 280 290 300
RGALAERQQK LAKHLADLHR LANLYDIAVF VTNQVQARPD AFFGDPTRPI
310 320 330 340
GGHILAHSAT LRVYLRKGKG GKRIARLIDA PHLPEGEAVF SITEKGIED
Length:349
Mass (Da):38,399
Last modified:November 1, 1998 - v1
Checksum:i726E9DF1D67AB039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052597 Genomic DNA. Translation: AAC34998.1.
AE009950 Genomic DNA. Translation: AAL82050.1.
RefSeqiWP_011013066.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL82050; AAL82050; PF1926.
GeneIDi1469806.
KEGGipfu:PF1926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052597 Genomic DNA. Translation: AAC34998.1.
AE009950 Genomic DNA. Translation: AAL82050.1.
RefSeqiWP_011013066.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PZNX-ray2.85A/B/C/D/E/F/G1-349[»]
4A6PX-ray1.50A108-349[»]
4A6XX-ray1.55A/B108-349[»]
4B2IX-ray1.30A108-349[»]
4B2LX-ray1.50A108-349[»]
4B2PX-ray1.60A108-349[»]
4B32X-ray1.50A108-349[»]
4B33X-ray1.50A108-349[»]
4B34X-ray1.55A108-349[»]
4B35X-ray1.40A108-349[»]
4B3BX-ray1.19A108-349[»]
4B3CX-ray1.90A108-349[»]
4B3DX-ray1.59A/C108-349[»]
4D6PX-ray1.48A/B108-349[»]
4UQOX-ray1.88A/B108-349[»]
5FOSX-ray1.35A108-349[»]
C93-108[»]
5FOTX-ray1.19A108-349[»]
5FOUX-ray1.50A108-349[»]
5FOVX-ray1.74A/C108-349[»]
5FOWX-ray1.80A/C108-349[»]
5FOXX-ray1.30A108-349[»]
5FPKX-ray1.34A108-349[»]
5J4HX-ray1.37A108-349[»]
5J4LX-ray1.13A108-349[»]
5JECX-ray2.34A/B108-349[»]
5JEDX-ray1.33A108-349[»]
5JEEX-ray1.49A108-349[»]
5KDDX-ray1.99A/B108-349[»]
5L8VX-ray1.50A108-349[»]
5LB2X-ray2.10A108-349[»]
5LB4X-ray1.98A108-349[»]
ProteinModelPortaliO74036.
SMRiO74036.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1926.

Chemistry databases

BindingDBiO74036.

Proteomic databases

PRIDEiO74036.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL82050; AAL82050; PF1926.
GeneIDi1469806.
KEGGipfu:PF1926.

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.
HOGENOMiHOG000227426.
KOiK04483.
OMAiCQLPIDQ.

Enzyme and pathway databases

BRENDAi3.6.4.B7. 5243.

Miscellaneous databases

EvolutionaryTraceiO74036.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRADA_PYRFU
AccessioniPrimary (citable) accession number: O74036
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.