ID   FWDC_METWO              Reviewed;         270 AA.
AC   O74031;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 45.
DE   RecName: Full=Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C;
DE            EC=1.2.99.5;
DE   AltName: Full=Tungsten-containing formylmethanofuran dehydrogenase II subunit C;
GN   Name=fwdC;
OS   Methanobacterium wolfei.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=145261;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=99035764; PubMed=9818358; DOI=10.1007/s002030050658;
RA   Hochheimer A., Hedderich R., Thauer R.K.;
RT   "The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium
RT   wolfei and Methanobacterium thermoautotrophicum: induction of the
RT   molybdenum isoenzyme by molybdate and constitutive synthesis of the
RT   tungsten isoenzyme.";
RL   Arch. Microbiol. 170:389-393(1998).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of CO(2) and
CC       methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme
CC       is oxygen-labile (By similarity).
CC   -!- CATALYTIC ACTIVITY: Formylmethanofuran + H(2)O + acceptor = CO(2)
CC       + methanofuran + reduced acceptor.
CC   -!- COFACTOR: Tungsten.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from carbone
CC       dioxide; 5,10-methenyl-H(4)MPT from CO(2): step 1/3.
CC   -!- SUBUNIT: This enzyme is composed of six subunits fwdA, fwdB, fwdC,
CC       fwdD, fwdF and fwdG (By similarity).
CC   -!- INDUCTION: By growth on tungsten or molybdenum under anaerobic
CC       conditions.
CC   -!- SIMILARITY: Belongs to the fwdC/fmdC family.
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DR   EMBL; AJ009688; CAA08784.1; -; Genomic_DNA.
DR   BRENDA; 1.2.99.5; 7575.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR002489; Glu_synthase_C.
DR   Gene3D; G3DSA:2.160.20.60; Glu_synthase_C; 1.
DR   Pfam; PF01493; GXGXG; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   2: Evidence at transcript level;
KW   Methanogenesis; Oxidoreductase; Repeat; Tungsten.
FT   CHAIN         1    270       Tungsten-containing formylmethanofuran
FT                                dehydrogenase 2 subunit C.
FT                                /FTId=PRO_0000144198.
FT   REPEAT       80     92       1.
FT   REPEAT       99    111       2.
FT   REPEAT      118    130       3.
FT   REPEAT      144    156       4.
FT   REPEAT      163    175       5.
FT   REPEAT      182    194       6.
FT   REPEAT      201    213       7.
FT   REGION       80    213       7 X 13 AA repeats of [GW]-X-X-M-X-X-G-X-
FT                                [IL]-X-[IV]-X-G.
SQ   SEQUENCE   270 AA;  28660 MW;  BB1061CBDF53061B CRC64;
     MSEIILTPKE QPEVPLEAPN IKPDVFAGKS IDEIKNIQIM HGNEVVKLGD FFEVSGEPAD
     APEDIKIIID GDVYNTKRIG QEMTAGEIIV RGNVNMYVGA GMKGGKITVE GNAGSWAGQD
     MRGGEIEILG DADDYVGSSY RGDWRGMSGG TITVHGNADN EIGEYMNGGK IIIKGDVNIM
     PGIHMNNGLI IIEGNVVARA GGEMAGGTIV VKGMMQEFLA GFKYLGVEKD IELMVKNSPG
     AFYKFEGDHA IKGAKGIVYA AVGCNGHIAP
//