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O74024

- DHE3_THEPR

UniProt

O74024 - DHE3_THEPR

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Protein
Glutamate dehydrogenase
Gene
gdhA, gdh
Organism
Thermococcus profundus
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi219 – 2257NAD Reviewed prediction

GO - Molecular functioni

  1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase (EC:1.4.1.3)
Short name:
GDH
Gene namesi
Name:gdhA
Synonyms:gdh
OrganismiThermococcus profundus
Taxonomic identifieri49899 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Glutamate dehydrogenase
PRO_0000182763Add
BLAST

Interactioni

Subunit structurei

Homohexamer By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1713
Helixi25 – 328
Beta strandi35 – 4511
Beta strandi51 – 6212
Beta strandi66 – 749
Helixi80 – 9617
Beta strandi102 – 1109
Helixi117 – 13115
Helixi132 – 1343
Turni137 – 1393
Beta strandi140 – 1434
Helixi150 – 16415
Helixi170 – 1734
Helixi179 – 1813
Helixi190 – 20617
Beta strandi214 – 2185
Helixi222 – 23312
Beta strandi238 – 2436
Beta strandi248 – 2503
Helixi257 – 26711
Beta strandi268 – 2703
Beta strandi277 – 2793
Helixi281 – 2844
Beta strandi290 – 2945
Beta strandi296 – 2994
Turni303 – 3053
Helixi306 – 3083
Beta strandi312 – 3154
Beta strandi318 – 3203
Helixi324 – 3329
Beta strandi336 – 3383
Helixi340 – 3434
Helixi346 – 35914
Helixi366 – 39126
Helixi395 – 41319

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EUZX-ray2.25A/B/C/D/E/F1-419[»]
ProteinModelPortaliO74024.
SMRiO74024. Positions 3-419.

Miscellaneous databases

EvolutionaryTraceiO74024.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74024-1 [UniParc]FASTAAdd to Basket

« Hide

MVEIDPFEMA VKQLERAAQY MDISEEALEW LKKPMRIVEV SVPIEMDDGS    50
VKVFTGFRVQ HNWARGPTKG GIRWHPAETL STVKALATWM TWKVAVVDLP 100
YGGGKGGIIV NPKELSEREQ ERLARAYIRA VYDVIGPWTD IPAPDVYTNP 150
KIMGWMMDEY ETIMRRKGPA FGVITGKPLS IGGSLGRGTA TAQGAIFTIR 200
EAAKALGIDL KGKKIAVQGY GNAGYYTAKL AKEQLGMTVV AVSDSRGGIY 250
NPDGLDPDEV LKWKREHGSV KDFPGATNIT NEELLELEVD VLAPAAIEEV 300
ITEKNADNIK AKIVAEVANG PVTPEADDIL REKGILQIPD FLCNAGGVTV 350
SYFEWVQNIN GYYWTEEEVR EKLDKKMTKA FWEVYNTHKD KNIHMRDAAY 400
VVAVSRVYQA MKDRGWVKK 419
Length:419
Mass (Da):46,700
Last modified:November 1, 1998 - v1
Checksum:i1DF3C1122E562706
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87814 Genomic DNA. Translation: BAA28943.1.
PIRiT44308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87814 Genomic DNA. Translation: BAA28943.1 .
PIRi T44308.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EUZ X-ray 2.25 A/B/C/D/E/F 1-419 [» ]
ProteinModelPortali O74024.
SMRi O74024. Positions 3-419.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei O74024.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, nucleotide sequence and expression in Escherichia coli of hyperthermophilic glutamate dehydrogenase gene from Thermococcus profundus."
    Higuchi S., Kobayashi T., Kimura K., Horikoshi K., Kudo T.
    J. Ferment. Bioeng. 83:405-411(1997)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHE3_THEPR
AccessioniPrimary (citable) accession number: O74024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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