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O74024

- DHE3_THEPR

UniProt

O74024 - DHE3_THEPR

Protein

Glutamate dehydrogenase

Gene

gdhA

Organism
Thermococcus profundus
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi219 – 2257NADSequence Analysis

    GO - Molecular functioni

    1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate dehydrogenase (EC:1.4.1.3)
    Short name:
    GDH
    Gene namesi
    Name:gdhA
    Synonyms:gdh
    OrganismiThermococcus profundus
    Taxonomic identifieri49899 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Glutamate dehydrogenasePRO_0000182763Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Structurei

    Secondary structure

    1
    419
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1713
    Helixi25 – 328
    Beta strandi35 – 4511
    Beta strandi51 – 6212
    Beta strandi66 – 749
    Helixi80 – 9617
    Beta strandi102 – 1109
    Helixi117 – 13115
    Helixi132 – 1343
    Turni137 – 1393
    Beta strandi140 – 1434
    Helixi150 – 16415
    Helixi170 – 1734
    Helixi179 – 1813
    Helixi190 – 20617
    Beta strandi214 – 2185
    Helixi222 – 23312
    Beta strandi238 – 2436
    Beta strandi248 – 2503
    Helixi257 – 26711
    Beta strandi268 – 2703
    Beta strandi277 – 2793
    Helixi281 – 2844
    Beta strandi290 – 2945
    Beta strandi296 – 2994
    Turni303 – 3053
    Helixi306 – 3083
    Beta strandi312 – 3154
    Beta strandi318 – 3203
    Helixi324 – 3329
    Beta strandi336 – 3383
    Helixi340 – 3434
    Helixi346 – 35914
    Helixi366 – 39126
    Helixi395 – 41319

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EUZX-ray2.25A/B/C/D/E/F1-419[»]
    ProteinModelPortaliO74024.
    SMRiO74024. Positions 3-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO74024.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O74024-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEIDPFEMA VKQLERAAQY MDISEEALEW LKKPMRIVEV SVPIEMDDGS    50
    VKVFTGFRVQ HNWARGPTKG GIRWHPAETL STVKALATWM TWKVAVVDLP 100
    YGGGKGGIIV NPKELSEREQ ERLARAYIRA VYDVIGPWTD IPAPDVYTNP 150
    KIMGWMMDEY ETIMRRKGPA FGVITGKPLS IGGSLGRGTA TAQGAIFTIR 200
    EAAKALGIDL KGKKIAVQGY GNAGYYTAKL AKEQLGMTVV AVSDSRGGIY 250
    NPDGLDPDEV LKWKREHGSV KDFPGATNIT NEELLELEVD VLAPAAIEEV 300
    ITEKNADNIK AKIVAEVANG PVTPEADDIL REKGILQIPD FLCNAGGVTV 350
    SYFEWVQNIN GYYWTEEEVR EKLDKKMTKA FWEVYNTHKD KNIHMRDAAY 400
    VVAVSRVYQA MKDRGWVKK 419
    Length:419
    Mass (Da):46,700
    Last modified:November 1, 1998 - v1
    Checksum:i1DF3C1122E562706
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87814 Genomic DNA. Translation: BAA28943.1.
    PIRiT44308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87814 Genomic DNA. Translation: BAA28943.1 .
    PIRi T44308.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EUZ X-ray 2.25 A/B/C/D/E/F 1-419 [» ]
    ProteinModelPortali O74024.
    SMRi O74024. Positions 3-419.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei O74024.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, nucleotide sequence and expression in Escherichia coli of hyperthermophilic glutamate dehydrogenase gene from Thermococcus profundus."
      Higuchi S., Kobayashi T., Kimura K., Horikoshi K., Kudo T.
      J. Ferment. Bioeng. 83:405-411(1997)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiDHE3_THEPR
    AccessioniPrimary (citable) accession number: O74024
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3