Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.1.29. 5244.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:PH1539
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203011 – 121Peptidyl-tRNA hydrolaseAdd BLAST121

Interactioni

Protein-protein interaction databases

STRINGi70601.PH1539.

Structurei

Secondary structure

1121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 17Combined sources11
Helixi21 – 42Combined sources22
Helixi44 – 52Combined sources9
Beta strandi57 – 64Combined sources8
Helixi65 – 77Combined sources13
Beta strandi82 – 86Combined sources5
Beta strandi98 – 107Combined sources10
Helixi108 – 115Combined sources8
Beta strandi118 – 120Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WN2X-ray1.20A1-121[»]
2D3KX-ray1.90A/B1-121[»]
ProteinModelPortaliO74017.
SMRiO74017.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO74017.

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04228. Archaea.
COG1990. LUCA.
HOGENOMiHOG000227349.
KOiK04794.
OMAiQVAHGAV.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
HAMAPiMF_00628. Pept_tRNA_hydro_arch. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.

Sequencei

Sequence statusi: Complete.

O74017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKMFKYKQV IVARADLKLS KGKLAAQVAH GAVTAAFEAY KKKREWFEAW
60 70 80 90 100
FREGQKKVVV KVESEEELFK LKAEAEKLGL PNALIRDAGL TEIPPGTVTV
110 120
LAVGPAPEEI VDKVTGNLKL L
Length:121
Mass (Da):13,377
Last modified:November 1, 1998 - v1
Checksum:iBE7129443A95F98B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30649.1.
PIRiA71031.

Genome annotation databases

EnsemblBacteriaiBAA30649; BAA30649; BAA30649.
KEGGipho:PH1539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA30649.1.
PIRiA71031.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WN2X-ray1.20A1-121[»]
2D3KX-ray1.90A/B1-121[»]
ProteinModelPortaliO74017.
SMRiO74017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH1539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA30649; BAA30649; BAA30649.
KEGGipho:PH1539.

Phylogenomic databases

eggNOGiarCOG04228. Archaea.
COG1990. LUCA.
HOGENOMiHOG000227349.
KOiK04794.
OMAiQVAHGAV.

Enzyme and pathway databases

BRENDAi3.1.1.29. 5244.

Miscellaneous databases

EvolutionaryTraceiO74017.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
HAMAPiMF_00628. Pept_tRNA_hydro_arch. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTH_PYRHO
AccessioniPrimary (citable) accession number: O74017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.