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O73986 (PORA_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate synthase subunit porA
EC=1.2.7.1
Alternative name(s):
Pyruvate oxidoreductase alpha chain
Short name=POR
Pyruvic-ferredoxin oxidoreductase subunit alpha
Gene names
Name:porA
Ordered Locus Names:PH0684
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.

Subunit structure

Heterotetramer of one alpha, one beta, one delta and one gamma chain By similarity.

Sequence caution

The sequence BAA29775.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionpyruvate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Pyruvate synthase subunit porA
PRO_0000099901

Sequences

Sequence LengthMass (Da)Tools
O73986 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: A49B2DADA3B9AC00

FASTA39543,911
        10         20         30         40         50         60 
MPIRTVMKAN EAAAWAAKLA KPKVIAAFPI TPSTLVPEKI SEFVANGELD AEFIKVESEH 

        70         80         90        100        110        120 
SAISAVVGAS AAGVRTFTAT ASQGLALMHE VLFIAAGMRL PIVMAIGNRS LSAPINIWND 

       130        140        150        160        170        180 
WQDSISQRDT GWIQFYAENN QEALDLILLA YKVAEDERVL LPAMVGFDAF ILTHTVEPVE 

       190        200        210        220        230        240 
IPDQEVVDEF LGEYEPKHAY LDPKRPITQG TLAFPAHYME AKYLVWDAME KARKVIDEAF 

       250        260        270        280        290        300 
AEFEKRFGRK YQKIEEYKTD DAEIIFVTMG SLAGTLKDWV DKKREEGYKV GAAKMTVYRP 

       310        320        330        340        350        360 
FPVEEIRALA KKAKVLGFIE KDISIGLYGA VFIDASAALV NESERPLMLD FIAGLGGRDV 

       370        380        390 
TFGQLDDALR IAEEALEKGE VEKPIHWIGL RKELL

« Hide

References

[1]"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3."
Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. expand/collapse author list , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.
DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000001 Genomic DNA. Translation: BAA29775.1. Different initiation.
PIRE71114.
RefSeqNP_142633.1. NC_000961.1.

3D structure databases

ProteinModelPortalO73986.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBPYRT00000000249; EBPYRP00000000249; EBPYRG00000000249.
GeneID1443011.
GenomeReviewsGene locus PH0684 in contig BA000001_GR.
KEGGpho:PH0684.
NMPDRfig|70601.1.peg.664.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000022252.
HOGENOMHBG313202.
OMAFTETKSC.
ProtClustDBPRK08367.

Enzyme and pathway databases

BioCycPHOR70601:PH0684-MONOMER.

Family and domain databases

InterProIPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00169.
PfamPF01855. POR_N. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
ProtoNetSearch...

Entry information

Entry namePORA_PYRHO
AccessionPrimary (citable) accession number: O73986
Secondary accession number(s): O58416
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 16, 2011
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
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