Reviewed, UniProtKB/Swiss-Prot O73986 (PORA_PYRHO)

Names and origin

Protein names

Recommended name:
    Pyruvate synthase subunit porA
    EC=1.2.7.1
Alternative name(s):
    Pyruvate oxidoreductase alpha chain
      Short name=POR
    Pyruvic-ferredoxin oxidoreductase subunit alpha

Gene names

Name:	porA
Ordered Locus Names:	PH0684

Organism

Pyrococcus horikoshii [Complete proteome] [HAMAP]

Taxonomic identifier

53953 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain By similarity.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Pyruvate synthase subunit porA		PRO_0000099901

Sequences

	Sequence		Length	Mass (Da)
	O73986-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: A49B2DADA3B9AC00	FASTA	395	43,911
	10 20 30 40 50 60 MPIRTVMKAN EAAAWAAKLA KPKVIAAFPI TPSTLVPEKI SEFVANGELD AEFIKVESEH 70 80 90 100 110 120 SAISAVVGAS AAGVRTFTAT ASQGLALMHE VLFIAAGMRL PIVMAIGNRS LSAPINIWND 130 140 150 160 170 180 WQDSISQRDT GWIQFYAENN QEALDLILLA YKVAEDERVL LPAMVGFDAF ILTHTVEPVE 190 200 210 220 230 240 IPDQEVVDEF LGEYEPKHAY LDPKRPITQG TLAFPAHYME AKYLVWDAME KARKVIDEAF 250 260 270 280 290 300 AEFEKRFGRK YQKIEEYKTD DAEIIFVTMG SLAGTLKDWV DKKREEGYKV GAAKMTVYRP 310 320 330 340 350 360 FPVEEIRALA KKAKVLGFIE KDISIGLYGA VFIDASAALV NESERPLMLD FIAGLGGRDV 370 380 390 TFGQLDDALR IAEEALEKGE VEKPIHWIGL RKELL

References

[1]

"Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3." Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S., Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K., Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T. , Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T., Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H. DNA Res. 5:55-76(1998) [PubMed: 9679194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OT3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000001 Genomic DNA. Translation: BAA29775.1. Different initiation.
PIR	E71114.
RefSeq	NP_142633.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1443011.
GenomeReviews	Gene locus PH0684 in contig BA000001_GR.
KEGG	pho:PH0684.
NMPDR	fig|70601.1.peg.664.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O73986.
Family and domain databases
InterPro	IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR015941. Transketolase_C-like. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF01855. POR_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PORA_PYRHO

Accession

Primary (citable) accession number: O73986
Secondary accession number(s): O58416

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	November 25, 2008
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)