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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-640-MONOMER
BRENDAi6.1.1.20 5244

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
Gene namesi
Name:pheT
Ordered Locus Names:PH0657
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270091 – 556Phenylalanine--tRNA ligase beta subunitAdd BLAST556

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi70601.PH0657

Structurei

Secondary structure

1556
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi8 – 15Combined sources8
Helixi21 – 30Combined sources10
Beta strandi33 – 41Combined sources9
Beta strandi44 – 51Combined sources8
Helixi57 – 59Combined sources3
Helixi62 – 72Combined sources11
Beta strandi84 – 93Combined sources10
Helixi95 – 97Combined sources3
Turni98 – 100Combined sources3
Beta strandi103 – 111Combined sources9
Helixi116 – 131Combined sources16
Turni132 – 138Combined sources7
Beta strandi139 – 146Combined sources8
Helixi147 – 149Combined sources3
Beta strandi152 – 159Combined sources8
Helixi176 – 182Combined sources7
Helixi184 – 189Combined sources6
Helixi190 – 192Combined sources3
Turni193 – 195Combined sources3
Beta strandi196 – 204Combined sources9
Beta strandi209 – 212Combined sources4
Turni213 – 215Combined sources3
Beta strandi216 – 222Combined sources7
Beta strandi230 – 238Combined sources9
Helixi240 – 255Combined sources16
Turni256 – 258Combined sources3
Beta strandi260 – 267Combined sources8
Beta strandi272 – 275Combined sources4
Beta strandi281 – 286Combined sources6
Helixi287 – 294Combined sources8
Helixi300 – 309Combined sources10
Beta strandi313 – 317Combined sources5
Beta strandi320 – 325Combined sources6
Helixi335 – 346Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXIX-ray1.94A/B/C1-348[»]
ProteinModelPortaliO73984
SMRiO73984
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO73984

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini278 – 353B5Add BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 138Poly-Arg4

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00412 Archaea
COG0072 LUCA
HOGENOMiHOG000105094
KOiK01890
OMAiTFTLCSR
OrthoDBiPOG093Z01M4

Family and domain databases

Gene3Di3.50.40.10, 1 hit
HAMAPiMF_00284 Phe_tRNA_synth_beta2, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR004531 Phe-tRNA-synth_IIc_bsu_arc
IPR020825 Phe-tRNA_synthase_B3/B4
IPR022918 Phe_tRNA_ligase_beta2_bac/arc
IPR005147 tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SUPFAMiSSF46955 SSF46955, 2 hits
TIGRFAMsiTIGR00471 pheT_arch, 1 hit
PROSITEiView protein in PROSITE
PS51483 B5, 1 hit

Sequencei

Sequence statusi: Complete.

O73984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFDVSKSD LERLIGRSFS IEEWEDLVLY AKCELDDVWE ENGKVYFKLD
60 70 80 90 100
SKDTNRPDLW SAEGVARQIK WALGIEKGLP KYEVKKSNVT VYVDEKLKDI
110 120 130 140 150
RPYGVYAIVE GLRLDEDSLS QMIQLQEKIA LTFGRRRREV AIGIFDFDKI
160 170 180 190 200
KPPIYYKAAE KTEKFAPLGY KEEMTLEEIL EKHEKGREYG HLIKDKQFYP
210 220 230 240 250
LLIDSEGNVL SMPPIINSEF TGRVTTDTKN VFIDVTGWKL EKVMLALNVM
260 270 280 290 300
VTALAERGGK IRSVRVVYKD FEIETPDLTP KEFEVELDYI RKLSGLELND
310 320 330 340 350
GEIKELLEKM MYEVEISRGR AKLKYPAFRD DIMHARDILE DVLIAYGYNN
360 370 380 390 400
IEPEEPKLAV QGRGDPFKDF EDAIRDLMVG FGLQEVMTFN LTNKEVQFKK
410 420 430 440 450
MNIPEEEIVE IANPISQRWS ALRKWILPSL MEFLSNNTHE EYPQRIFEVG
460 470 480 490 500
LATLIDESRE TKTVSEPKLA VALAGTGYTF TNAKEILDAL MRHLGFEYEI
510 520 530 540 550
EEVEHGSFIP GRAGKIIVNG RDIGIIGEVH PQVLENWNIE VPVVAFEIFL

RPLYRH
Length:556
Mass (Da):64,195
Last modified:November 1, 1998 - v1
Checksum:iD3DB228E4AB7CBC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA29748.1
PIRiB71111
RefSeqiWP_010884752.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA29748; BAA29748; BAA29748
GeneIDi1442987
KEGGipho:PH0657

Similar proteinsi

Entry informationi

Entry nameiSYFB_PYRHO
AccessioniPrimary (citable) accession number: O73984
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health