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Protein

Pyruvate kinase

Gene

PH0570

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (PH0570)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciPHOR70601:GJWR-565-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Ordered Locus Names:PH0570Imported
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)Imported
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi70601.PH0570.

Structurei

3D structure databases

ProteinModelPortaliO73980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 343335PKInterPro annotationAdd
BLAST
Domaini366 – 474109PK_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04120. Archaea.
COG0469. LUCA.
HOGENOMiHOG000021558.
KOiK00873.
OMAiGTHEEHK.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

O73980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRMKLPSHK TKIVATIGPA TNSKKMIKKL IEAGMNVARI NFSHGTFEEH
60 70 80 90 100
AKIIEMVREQ SQKLDRRVAI LADLPGLKIR VGEIKGGYVE LERGEKVTLT
110 120 130 140 150
TKDIEGDETT IPVEYKDFPK LVSKGDVIYL SDGYIVLRVE DVKENEVEAV
160 170 180 190 200
VISGGKLFSR KGINIPKAYL PVEAITPRDI EIMKFAIEHG VDAIGLSFVG
210 220 230 240 250
NVYDVLKAKS FLERNGAGDT FVIAKIERPD AVRNFNEILN AADGIMIARG
260 270 280 290 300
DLGVEMPIEQ LPILQKRLIR KANMEGKPVI TATQMLVSMT MEKVPTRAEV
310 320 330 340 350
TDVANAILDG TDAVMLSEET AVGKFPIEAV EMMARIAKVT EEYRESFGIT
360 370 380 390 400
RMREFLEGTK RGTIKEAITR SIIDAICTIG IKFILTPTKT GRTARLISRF
410 420 430 440 450
KPKQWILAFS TREKVCNNLM FSYGVYPFCM EEGFNENDIV RLIKGLGLVG
460 470
SDDIVLMTEG KPIEKTVGTN SIKIFQIA
Length:478
Mass (Da):53,175
Last modified:November 1, 1998 - v1
Checksum:i66A2263B84BDC5D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29659.1.
PIRiF71171.

Genome annotation databases

EnsemblBacteriaiBAA29659; BAA29659; BAA29659.
KEGGipho:PH0570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA. Translation: BAA29659.1.
PIRiF71171.

3D structure databases

ProteinModelPortaliO73980.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi70601.PH0570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA29659; BAA29659; BAA29659.
KEGGipho:PH0570.

Phylogenomic databases

eggNOGiarCOG04120. Archaea.
COG0469. LUCA.
HOGENOMiHOG000021558.
KOiK00873.
OMAiGTHEEHK.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.
BioCyciPHOR70601:GJWR-565-MONOMER.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3Imported.

Entry informationi

Entry nameiO73980_PYRHO
AccessioniPrimary (citable) accession number: O73980
Secondary accession number(s): O58305
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.