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Protein

Pterin-4-alpha-carbinolamine dehydratase

Gene

PCBD1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity).By similarity

Catalytic activityi

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Lyase

Keywords - Biological processi

Tetrahydrobiopterin biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-GGA-71182. Phenylalanine and tyrosine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Pterin-4-alpha-carbinolamine dehydratase (EC:4.2.1.96)
Short name:
PHS
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Dimerization cofactor of hepatocyte nuclear factor 1-alpha
Short name:
DCoH
Short name:
Dimerization cofactor of HNF1
Short name:
cDcoH
Phenylalanine hydroxylase-stimulating protein
Pterin carbinolamine dehydratase
Short name:
PCD
Gene namesi
Name:PCBD1
Synonyms:DCOH, PCBD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 6

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Cytoplasmic and/or nuclear.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000630552 – 104Pterin-4-alpha-carbinolamine dehydrataseAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

The major tissues expressing cDcoH are hypothalamus, kidney and liver.1 Publication

Gene expression databases

BgeeiENSGALG00000027835.

Structurei

3D structure databases

ProteinModelPortaliO73930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 63Substrate bindingBy similarity3
Regioni78 – 81Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000007221.
HOVERGENiHBG000259.
InParanoidiO73930.
KOiK01724.
OMAiIKAQEMD.
OrthoDBiEOG091G120V.
PhylomeDBiO73930.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
HAMAPiMF_00434. Pterin_4_alpha. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKAHRLNA EEREQLLPNL RAVGWNEVEG RDAIFKEFHF KDFNRAFGFM
60 70 80 90 100
TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECTGLSERDI NLASFIEQVA

ASLS
Length:104
Mass (Da):11,998
Last modified:January 23, 2007 - v3
Checksum:i0786C7DF71A4EA99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005158 Genomic DNA. Translation: CAA06395.1.
AJ005157 mRNA. Translation: CAA06394.1.
RefSeqiNP_990236.1. NM_204905.1.
UniGeneiGga.427.

Genome annotation databases

EnsembliENSGALT00000045018; ENSGALP00000043457; ENSGALG00000027835.
GeneIDi395729.
KEGGigga:395729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005158 Genomic DNA. Translation: CAA06395.1.
AJ005157 mRNA. Translation: CAA06394.1.
RefSeqiNP_990236.1. NM_204905.1.
UniGeneiGga.427.

3D structure databases

ProteinModelPortaliO73930.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000045018; ENSGALP00000043457; ENSGALG00000027835.
GeneIDi395729.
KEGGigga:395729.

Organism-specific databases

CTDi5092.

Phylogenomic databases

GeneTreeiENSGT00390000007221.
HOVERGENiHBG000259.
InParanoidiO73930.
KOiK01724.
OMAiIKAQEMD.
OrthoDBiEOG091G120V.
PhylomeDBiO73930.

Enzyme and pathway databases

ReactomeiR-GGA-71182. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

PROiO73930.

Gene expression databases

BgeeiENSGALG00000027835.

Family and domain databases

Gene3Di3.30.1360.20. 1 hit.
HAMAPiMF_00434. Pterin_4_alpha. 1 hit.
InterProiIPR001533. Trans/pterin_deHydtase.
[Graphical view]
PANTHERiPTHR12599. PTHR12599. 1 hit.
PfamiPF01329. Pterin_4a. 1 hit.
[Graphical view]
SUPFAMiSSF55248. SSF55248. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHS_CHICK
AccessioniPrimary (citable) accession number: O73930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.