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Protein

Multifunctional fusion protein

Gene

k60

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation, Inflammatory responseUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-380108 Chemokine receptors bind chemokines
R-GGA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
C-X-C motif chemokineUniRule annotation
Interleukin-8UniRule annotation
Short name:
IL-8UniRule annotation
Alternative name(s):
C-X-C motif chemokine 8UniRule annotation
Chemokine (C-X-C motif) ligand 8UniRule annotation
Gene namesi
Name:k60Imported
Synonyms:CXCL8UniRule annotation, IL8L1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_501420571121 – 104Multifunctional fusion proteinUniRule annotationAdd BLAST84

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000011668

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019049

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 92SCYInterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J24U Eukaryota
ENOG410Z1BP LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
KOiK10030
OMAiAIELRCQ
OrthoDBiEOG091G0YLH
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR028469 Interleukin-8
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF68 PTHR10179:SF68, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

O73912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGKAVAAVM ALLLISMAGA KGMAQARSAI ELRCQCIETH SKFIHPKFIQ
60 70 80 90 100
NVNLTPSGPH CKNVEVIATL KDGREVCLDP TAPWVKLIIK AILDKADTNN

KTAS
Length:104
Mass (Da):11,199
Last modified:August 1, 1998 - v1
Checksum:i83725AB91FE18E3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000018 Genomic DNA No translation available.
AF277660 Genomic DNA Translation: AAF86485.1
Y14971 mRNA Translation: CAA75212.1
RefSeqiNP_990349.1, NM_205018.1
UniGeneiGga.512

Genome annotation databases

EnsembliENSGALT00000019072; ENSGALP00000019049; ENSGALG00000011668
GeneIDi395872
KEGGigga:395872

Similar proteinsi

Entry informationi

Entry nameiO73912_CHICK
AccessioniPrimary (citable) accession number: O73912
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health