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Protein

Multifunctional fusion protein

Gene

k60

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation
Biological processChemotaxisUniRule annotation, Inflammatory responseUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-380108. Chemokine receptors bind chemokines.
R-GGA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
C-X-C motif chemokineUniRule annotation
Interleukin-8UniRule annotation
Short name:
IL-8UniRule annotation
Alternative name(s):
C-X-C motif chemokine 8UniRule annotation
Chemokine (C-X-C motif) ligand 8UniRule annotation
Gene namesi
Name:k60Imported
Synonyms:CXCL8UniRule annotation, IL8L1Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500999833721 – 104Multifunctional fusion proteinUniRule annotationAdd BLAST84

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000011668.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019049.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 92SCYInterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
OMAiAIELRCQ.
OrthoDBiEOG091G0YLH.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR028469. Interleukin-8.
IPR036048. Interleukin_8-like_sf.
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF68. PTHR10179:SF68. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00471. SMALL_CYTOKINES_CXC. 1 hit.

Sequencei

Sequence statusi: Complete.

O73912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGKAVAAVM ALLLISMAGA KGMAQARSAI ELRCQCIETH SKFIHPKFIQ
60 70 80 90 100
NVNLTPSGPH CKNVEVIATL KDGREVCLDP TAPWVKLIIK AILDKADTNN

KTAS
Length:104
Mass (Da):11,199
Last modified:August 1, 1998 - v1
Checksum:i83725AB91FE18E3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000018 Genomic DNA. No translation available.
AF277660 Genomic DNA. Translation: AAF86485.1.
Y14971 mRNA. Translation: CAA75212.1.
RefSeqiNP_990349.1. NM_205018.1.
UniGeneiGga.512.

Genome annotation databases

EnsembliENSGALT00000019072; ENSGALP00000019049; ENSGALG00000011668.
GeneIDi395872.

Similar proteinsi

Entry informationi

Entry nameiO73912_CHICK
AccessioniPrimary (citable) accession number: O73912
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 22, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported