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Protein

C-X-C motif chemokine

Gene

k60

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-375276. Peptide ligand-binding receptors.
R-GGA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokineUniRule annotation
Gene namesi
Name:k60Imported
Synonyms:IL8L1Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_500845193321 – 104C-X-C motif chemokineUniRule annotationAdd BLAST84

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000011668.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019049.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 92SCYInterPro annotationAdd BLAST62

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
KOiK10030.
OMAiHCRCIQT.
OrthoDBiEOG091G0YLH.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGKAVAAVM ALLLISMAGA KGMAQARSAI ELRCQCIETH SKFIHPKFIQ
60 70 80 90 100
NVNLTPSGPH CKNVEVIATL KDGREVCLDP TAPWVKLIIK AILDKADTNN

KTAS
Length:104
Mass (Da):11,199
Last modified:August 1, 1998 - v1
Checksum:i83725AB91FE18E3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000018 Genomic DNA. No translation available.
AF277660 Genomic DNA. Translation: AAF86485.1.
Y14971 mRNA. Translation: CAA75212.1.
RefSeqiNP_990349.1. NM_205018.1.
UniGeneiGga.512.

Genome annotation databases

EnsembliENSGALT00000019072; ENSGALP00000019049; ENSGALG00000011668.
GeneIDi395872.
KEGGigga:395872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000018 Genomic DNA. No translation available.
AF277660 Genomic DNA. Translation: AAF86485.1.
Y14971 mRNA. Translation: CAA75212.1.
RefSeqiNP_990349.1. NM_205018.1.
UniGeneiGga.512.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000019072; ENSGALP00000019049; ENSGALG00000011668.
GeneIDi395872.
KEGGigga:395872.

Organism-specific databases

CTDi395872.

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
KOiK10030.
OMAiHCRCIQT.
OrthoDBiEOG091G0YLH.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-GGA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-GGA-375276. Peptide ligand-binding receptors.
R-GGA-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSGALG00000011668.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO73912_CHICK
AccessioniPrimary (citable) accession number: O73912
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.