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Protein

Interleukin-1

Gene

il-1beta

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: AgBase
  • interleukin-1 receptor binding Source: InterPro

GO - Biological processi

  • acute-phase response Source: AgBase
  • cellular response to cold Source: AgBase
  • chemokine production Source: AgBase
  • cortisol secretion Source: AgBase
  • detection of lipopolysaccharide Source: AgBase
  • fever generation Source: AgBase
  • immune response Source: InterPro
  • inflammatory response Source: AgBase
  • leukocyte activation involved in inflammatory response Source: AgBase
  • leukocyte chemotaxis involved in inflammatory response Source: AgBase
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of inflammatory response Source: AgBase
  • response to virus Source: AgBase
  • sexual reproduction Source: AgBase
  • toll-like receptor signaling pathway Source: AgBase

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation, MitogenUniRule annotation, PyrogenUniRule annotation
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-GGA-446652. Interleukin-1 family signaling.
R-GGA-448706. Interleukin-1 processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1UniRule annotation
Gene namesi
Name:il-1betaImported
Synonyms:IL1BImported, IL1betaImported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000000534.

Interactioni

Subunit structurei

Monomer.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: AgBase
  • interleukin-1 receptor binding Source: InterPro

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WRYX-ray1.58A106-267[»]
3NJ5X-ray1.67A106-267[»]
4X37X-ray1.63A106-267[»]
4X38X-ray2.12A106-267[»]
4X39X-ray1.61A106-267[»]
4X3AX-ray1.75A106-267[»]
SMRiO73909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 92IL1_propepInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
GeneTreeiENSGT00510000048687.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
KOiK04519.
OrthoDBiEOG091G0GR9.
TreeFamiTF300203.

Family and domain databases

InterProiView protein in InterPro
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
IPR008996. IL1/FGF.
PANTHERiPTHR44849. PTHR44849. 1 hit.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00253. INTERLEUKIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

O73909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVPDLDVL ESSSLSEETF YGPSCLCLQK KPRLDSEHTT VDVQVTVRKG
60 70 80 90 100
RGARSFRRAA VLVVAMTKLL RRPRSRDFAD SDLSALLEEV FEPVTFQRLE
110 120 130 140 150
SSYAGAPAFR YTRSQSFDIF DINQKCFVLE SPTQLVALHL QGPSSSQKVR
160 170 180 190 200
LNIALYRPRG PRGSAGTGQM PVALGIKGYK LYMSCVMSGT EPTLQLEEAD
210 220 230 240 250
VMRDIDSVEL TRFIFYRLDS PTEGTTRFES AAFPGWFICT SLQPRQPVGI
260
TNQPDQVNIA TYKLSGR
Length:267
Mass (Da):29,822
Last modified:August 1, 1998 - v1
Checksum:i3EF72164E4D40B64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000410 Genomic DNA. No translation available.
DQ393267 mRNA. Translation: ABD49198.1.
FJ788633 mRNA. Translation: ACY72339.1.
HM179638 mRNA. Translation: ADL14562.1.
Y15006 mRNA. Translation: CAA75239.1.
AJ245728 Genomic DNA. Translation: CAC04510.1.
RefSeqiNP_989855.1. NM_204524.1.
UniGeneiGga.19.

Genome annotation databases

EnsembliENSGALT00000075268; ENSGALP00000050171; ENSGALG00000029940.
GeneIDi395196.
KEGGigga:395196.

Similar proteinsi

Entry informationi

Entry nameiO73909_CHICK
AccessioniPrimary (citable) accession number: O73909
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported