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Protein

Interleukin-1

Gene

il-1beta

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: AgBase
  • interleukin-1 receptor binding Source: UniProtKB-UniRule

GO - Biological processi

  • acute-phase response Source: AgBase
  • cellular response to cold Source: AgBase
  • chemokine production Source: AgBase
  • cortisol secretion Source: AgBase
  • detection of lipopolysaccharide Source: AgBase
  • fever generation Source: AgBase
  • immune response Source: InterPro
  • inflammatory response Source: AgBase
  • leukocyte activation involved in inflammatory response Source: AgBase
  • leukocyte chemotaxis involved in inflammatory response Source: AgBase
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of inflammatory response Source: AgBase
  • response to virus Source: AgBase
  • sexual reproduction Source: AgBase
  • toll-like receptor signaling pathway Source: AgBase

Keywordsi

Molecular functionCytokineUniRule annotationSAAS annotation, MitogenUniRule annotation, PyrogenUniRule annotation
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-GGA-448706 Interleukin-1 processing
R-GGA-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1UniRule annotation
Gene namesi
Name:il-1betaImported
Synonyms:IL1BImported, IL1betaImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000000534

Interactioni

Subunit structurei

Monomer.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: AgBase
  • interleukin-1 receptor binding Source: UniProtKB-UniRule

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WRYX-ray1.58A106-267[»]
3NJ5X-ray1.67A106-267[»]
4X37X-ray1.63A106-267[»]
4X38X-ray2.12A106-267[»]
4X39X-ray1.61A106-267[»]
4X3AX-ray1.75A106-267[»]
SMRiO73909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 92IL1_propepInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGSZ Eukaryota
ENOG410XU2E LUCA
GeneTreeiENSGT00510000048687
HOGENOMiHOG000246399
HOVERGENiHBG007328
KOiK04519
OrthoDBiEOG091G0GR9
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003296 IL-1_beta
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR44849 PTHR44849, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

O73909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVPDLDVL ESSSLSEETF YGPSCLCLQK KPRLDSEHTT VDVQVTVRKG
60 70 80 90 100
RGARSFRRAA VLVVAMTKLL RRPRSRDFAD SDLSALLEEV FEPVTFQRLE
110 120 130 140 150
SSYAGAPAFR YTRSQSFDIF DINQKCFVLE SPTQLVALHL QGPSSSQKVR
160 170 180 190 200
LNIALYRPRG PRGSAGTGQM PVALGIKGYK LYMSCVMSGT EPTLQLEEAD
210 220 230 240 250
VMRDIDSVEL TRFIFYRLDS PTEGTTRFES AAFPGWFICT SLQPRQPVGI
260
TNQPDQVNIA TYKLSGR
Length:267
Mass (Da):29,822
Last modified:August 1, 1998 - v1
Checksum:i3EF72164E4D40B64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000410 Genomic DNA No translation available.
DQ393267 mRNA Translation: ABD49198.1
FJ788633 mRNA Translation: ACY72339.1
HM179638 mRNA Translation: ADL14562.1
Y15006 mRNA Translation: CAA75239.1
AJ245728 Genomic DNA Translation: CAC04510.1
RefSeqiNP_989855.1, NM_204524.1
UniGeneiGga.19

Genome annotation databases

EnsembliENSGALT00000075268; ENSGALP00000050171; ENSGALG00000029940
GeneIDi395196
KEGGigga:395196

Similar proteinsi

Entry informationi

Entry nameiO73909_CHICK
AccessioniPrimary (citable) accession number: O73909
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health