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Protein
Submitted name:

IL-1 beta

Gene

il-1beta

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation, MitogenUniRule annotation, PyrogenUniRule annotation

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-GGA-446652. Interleukin-1 signaling.
R-GGA-448706. Interleukin-1 processing.

Names & Taxonomyi

Protein namesi
Submitted name:
IL-1 betaImported
Submitted name:
Interleukin-1 betaImported
Submitted name:
Interleukin-1betaImported
Gene namesi
Name:il-1betaImported
Synonyms:IL1BImported, IL1betaImported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000737.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WRYX-ray1.58A106-267[»]
3NJ5X-ray1.67A106-267[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 9259IL1_propepInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the IL-1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
KOiK04519.
OrthoDBiEOG71P2BQ.
PhylomeDBiO73909.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERiPTHR10078:SF20. PTHR10078:SF20. 1 hit.
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVPDLDVL ESSSLSEETF YGPSCLCLQK KPRLDSEHTT VDVQVTVRKG
60 70 80 90 100
RGARSFRRAA VLVVAMTKLL RRPRSRDFAD SDLSALLEEV FEPVTFQRLE
110 120 130 140 150
SSYAGAPAFR YTRSQSFDIF DINQKCFVLE SPTQLVALHL QGPSSSQKVR
160 170 180 190 200
LNIALYRPRG PRGSAGTGQM PVALGIKGYK LYMSCVMSGT EPTLQLEEAD
210 220 230 240 250
VMRDIDSVEL TRFIFYRLDS PTEGTTRFES AAFPGWFICT SLQPRQPVGI
260
TNQPDQVNIA TYKLSGR
Length:267
Mass (Da):29,822
Last modified:August 1, 1998 - v1
Checksum:i3EF72164E4D40B64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ393267 mRNA. Translation: ABD49198.1.
FJ788633 mRNA. Translation: ACY72339.1.
HM179638 mRNA. Translation: ADL14562.1.
Y15006 mRNA. Translation: CAA75239.1.
AJ245728 Genomic DNA. Translation: CAC04510.1.
RefSeqiNP_989855.1. NM_204524.1.
UniGeneiGga.19.

Genome annotation databases

GeneIDi395196.
KEGGigga:395196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ393267 mRNA. Translation: ABD49198.1.
FJ788633 mRNA. Translation: ACY72339.1.
HM179638 mRNA. Translation: ADL14562.1.
Y15006 mRNA. Translation: CAA75239.1.
AJ245728 Genomic DNA. Translation: CAC04510.1.
RefSeqiNP_989855.1. NM_204524.1.
UniGeneiGga.19.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WRYX-ray1.58A106-267[»]
3NJ5X-ray1.67A106-267[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395196.
KEGGigga:395196.

Organism-specific databases

CTDi3553.

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
HOGENOMiHOG000246399.
HOVERGENiHBG007328.
KOiK04519.
OrthoDBiEOG71P2BQ.
PhylomeDBiO73909.
TreeFamiTF300203.

Enzyme and pathway databases

ReactomeiR-GGA-446652. Interleukin-1 signaling.
R-GGA-448706. Interleukin-1 processing.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003294. IL-1_alpha/beta.
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PANTHERiPTHR10078:SF20. PTHR10078:SF20. 1 hit.
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A chicken homolog of mammalian interleukin-1 beta: cDNA cloning and purification of active recombinant protein."
    Weining K.C., Sick C., Kaspers B., Staeheli P.
    Eur. J. Biochem. 258:994-1000(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Chicken interleukin-1b: an evolutionary bridge between fish and mammals."
    Kaiser P., Rothwell L., Goodchild M., Bumstead N.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Line NImported.
  3. "Sequence and phylogenetic analysis of interleukin (IL)-1beta-encoding genes of five avian species and structural and functional homology among these IL-1beta proteins."
    Wu Y.F., Liu H.J., Chiou S.H., Lee L.H.
    Vet. Immunol. Immunopathol. 116:37-46(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Cloning and sequence analysis of interleukin-1beta of China Lushi chicken."
    Zhang X., Zhang C., Li Y., Cheng X., Wu T.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Periphery blood lymphocytesImported.
  5. "Molecular characterization of IL1-Beta in red jungle fowl."
    Megra M., Mehra S., Shukla S.K., Goyal G., Ahmed S.U., Sharma D.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "Structural and functional comparison of cytokine interleukin-1 beta from chicken and human."
    Cheng C.S., Chen W.T., Lee L.H., Chen Y.W., Chang S.Y., Lyu P.C., Yin H.S.
    Mol. Immunol. 48:947-955(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 106-267.

Entry informationi

Entry nameiO73909_CHICK
AccessioniPrimary (citable) accession number: O73909
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.