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Protein

Heat shock cognate 71 kDa protein

Gene

HSPA8

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone. May play a role in regulating apoptosis during embryonic development.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock cognate 71 kDa protein
Alternative name(s):
Heat shock 70 kDa protein 8
Gene namesi
Name:HSPA8
Synonyms:HSC70
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 646646Heat shock cognate 71 kDa proteinPRO_0000304725Add
BLAST

Proteomic databases

PaxDbiO73885.
PRIDEiO73885.

Expressioni

Developmental stagei

First detected at 0.5 days of embryonic development (at protein level). Detected at higher levels from 1 to 2.5 days of embryonic development (at protein level). First detected at 0.5 days of embryonic development. Levels increase strongly from 1 to 2.5 days of embryonic development.1 Publication

Inductioni

Up-regulated by insulin in cultured embryos.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi676126. 2 interactions.
IntActiO73885. 1 interaction.
STRINGi9031.ENSGALP00000040138.

Structurei

3D structure databases

ProteinModelPortaliO73885.
SMRiO73885. Positions 1-621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiO73885.
KOiK03283.
PhylomeDBiO73885.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL
60 70 80 90 100
IGDAAKNQVA MNPTNTVFDA KRLIGRRFDD SVVQSDMKHW PFTVVNDAGR
110 120 130 140 150
PKVQVEYKGE TKSFYPEEIS SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF
160 170 180 190 200
NDSQRQGTKD AGTIAGLNVL RIINEPTAAA IAYGLDKKVG AERNLLIFDL
210 220 230 240 250
GGGTFDVSIL TIENGIFEVK STAGDTHLGG EDFDNRLVNH FIAEFKRKHK
260 270 280 290 300
KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA
310 320 330 340 350
RFEKLNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL
360 370 380 390 400
QDFFNGKELN KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS
410 420 430 440 450
LGIETAGGVM TVLIKRNTTI PTKQTQTFTT YSDNQPGVLI QVYEGERAMT
460 470 480 490 500
KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI DANGILNVSA VDKSTGKENK
510 520 530 540 550
ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN SLDSYAFNMK
560 570 580 590 600
ATVEDEKLPG KILDEDHQNI LDKCNEIINW LDKNQTAEKE EFEHQQKELE
610 620 630 640
KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD
Length:646
Mass (Da):70,827
Last modified:August 1, 1998 - v1
Checksum:i2151332ED42C5B9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ004940 mRNA. Translation: CAA06233.1.
RefSeqiNP_990334.1. NM_205003.2.
UniGeneiGga.4555.

Genome annotation databases

GeneIDi395853.
KEGGigga:395853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ004940 mRNA. Translation: CAA06233.1.
RefSeqiNP_990334.1. NM_205003.2.
UniGeneiGga.4555.

3D structure databases

ProteinModelPortaliO73885.
SMRiO73885. Positions 1-621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676126. 2 interactions.
IntActiO73885. 1 interaction.
STRINGi9031.ENSGALP00000040138.

Proteomic databases

PaxDbiO73885.
PRIDEiO73885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395853.
KEGGigga:395853.

Organism-specific databases

CTDi3312.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiO73885.
KOiK03283.
PhylomeDBiO73885.

Miscellaneous databases

NextBioi20815920.
PROiO73885.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis."
    de la Rosa E.J., Vega-Nunez E., Morales A.V., Serna J., Rubio E., de Pablo F.
    Proc. Natl. Acad. Sci. U.S.A. 95:9950-9955(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, DEVELOPMENTAL STAGE.
    Strain: White leghorn.
    Tissue: Embryo.

Entry informationi

Entry nameiHSP7C_CHICK
AccessioniPrimary (citable) accession number: O73885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 1, 1998
Last modified: February 17, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.