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Protein

Superoxide dismutase [Cu-Zn]

Gene

sod1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Copper; catalyticBy similarity
Metal bindingi49 – 491Copper; catalyticBy similarity
Metal bindingi64 – 641Copper; catalyticBy similarity
Metal bindingi64 – 641Zinc; structuralBy similarity
Metal bindingi72 – 721Zinc; structuralBy similarity
Metal bindingi81 – 811Zinc; structuralBy similarity
Metal bindingi84 – 841Zinc; structuralBy similarity
Metal bindingi121 – 1211Copper; catalyticBy similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: ZFIN

GO - Biological processi

  • neuron cellular homeostasis Source: ZFIN
  • removal of superoxide radicals Source: GOC
  • response to metal ion Source: ZFIN
  • response to methylmercury Source: ZFIN
  • response to xenobiotic stimulus Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sod1
Synonyms:cuzn
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-990415-258. sod1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Superoxide dismutase [Cu-Zn]PRO_0000164071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi7 – 71S-palmitoyl cysteineBy similarity
Disulfide bondi58 ↔ 147By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO73872.
PRIDEiO73872.

Expressioni

Gene expression databases

BgeeiO73872.
ExpressionAtlasiO73872. differential.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064375.

Structurei

3D structure databases

ProteinModelPortaliO73872.
SMRiO73872. Positions 4-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
InParanoidiO73872.
KOiK04565.
OMAiVCVLKGT.
OrthoDBiEOG776SR4.
PhylomeDBiO73872.
TreeFamiTF105131.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNKAVCVLK GTGEVTGTVY FNQEGEKKPV KVTGEITGLT PGKHGFHVHA
60 70 80 90 100
FGDNTNGCIS AGPHFNPHDK THGGPTDSVR HVGDLGNVTA DASGVAKIEI
110 120 130 140 150
EDAMLTLSGQ HSIIGRTMVI HEKEDDLGKG GNEESLKTGN AGGRLACGVI

GITQ
Length:154
Mass (Da):15,953
Last modified:August 1, 1998 - v1
Checksum:i62F44CA146C5057C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12236 mRNA. Translation: CAA72925.1.
BC055516 mRNA. Translation: AAH55516.1.
RefSeqiNP_571369.1. NM_131294.1.
UniGeneiDr.75822.

Genome annotation databases

EnsembliENSDART00000064376; ENSDARP00000064375; ENSDARG00000043848.
GeneIDi30553.
KEGGidre:30553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12236 mRNA. Translation: CAA72925.1.
BC055516 mRNA. Translation: AAH55516.1.
RefSeqiNP_571369.1. NM_131294.1.
UniGeneiDr.75822.

3D structure databases

ProteinModelPortaliO73872.
SMRiO73872. Positions 4-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064375.

Proteomic databases

PaxDbiO73872.
PRIDEiO73872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000064376; ENSDARP00000064375; ENSDARG00000043848.
GeneIDi30553.
KEGGidre:30553.

Organism-specific databases

CTDi6647.
ZFINiZDB-GENE-990415-258. sod1.

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
HOGENOMiHOG000263447.
HOVERGENiHBG000062.
InParanoidiO73872.
KOiK04565.
OMAiVCVLKGT.
OrthoDBiEOG776SR4.
PhylomeDBiO73872.
TreeFamiTF105131.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiO73872.

Gene expression databases

BgeeiO73872.
ExpressionAtlasiO73872. differential.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a cDNA for Cu/Zn-superoxide dismutase from zebrafish."
    Ken C.F., Lin C.T.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSODC_DANRE
AccessioniPrimary (citable) accession number: O73872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.