Reviewed, UniProtKB/Swiss-Prot O73872 (SODC_DANRE)

Names and origin

Protein names

Recommended name:
    Superoxide dismutase [Cu-Zn]
    EC=1.15.1.1

Gene names

Name:	sod1
Synonyms:	cuzn

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to metal ion Inferred from direct assay. Source: ZFIN response to methylmercury Inferred from direct assay. Source: ZFIN response to xenobiotic stimulus Inferred from direct assay. Source: ZFIN superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antioxidant activity Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from direct assay. Source: ZFIN zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 154	154	Superoxide dismutase [Cu-Zn]		PRO_0000164071
Sites
	Metal binding	47	1	Copper; catalytic By similarity
	Metal binding	49	1	Copper; catalytic By similarity
	Metal binding	64	1	Copper; catalytic By similarity
	Metal binding	64	1	Zinc; structural By similarity
	Metal binding	72	1	Zinc; structural By similarity
	Metal binding	81	1	Zinc; structural By similarity
	Metal binding	84	1	Zinc; structural By similarity
	Metal binding	121	1	Copper; catalytic By similarity
Amino acid modifications
	Disulfide bond	58 ↔ 147		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O73872-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 62F44CA146C5057C	FASTA	154	15,953
	10 20 30 40 50 60 MVNKAVCVLK GTGEVTGTVY FNQEGEKKPV KVTGEITGLT PGKHGFHVHA FGDNTNGCIS 70 80 90 100 110 120 AGPHFNPHDK THGGPTDSVR HVGDLGNVTA DASGVAKIEI EDAMLTLSGQ HSIIGRTMVI 130 140 150 HEKEDDLGKG GNEESLKTGN AGGRLACGVI GITQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a cDNA for Cu/Zn-superoxide dismutase from zebrafish." Ken C.F., Lin C.T. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y12236 mRNA. Translation: CAA72925.1. BC055516 mRNA. Translation: AAH55516.1.
IPI	IPI00490809.
RefSeq	NP_571369.1.
UniGene	Dr.75822
3D structure databases
HSSP	HSSP built from PDB template 1HL4 based on UniProtKB P00441.
SMR	O73872. Positions 4-154.
ModBase	Search...
Protein-protein interaction databases
STRING	O73872.
Proteomic databases
PRIDE	O73872.
Genome annotation databases
Ensembl	ENSDART00000064376; ENSDARP00000064375; ENSDARG00000043848; Danio rerio. [Genome view]
GeneID	30553.
KEGG	dre:30553.
Organism-specific databases
CTD	30553.
ZFIN	ZDB-GENE-990415-258. sod1.
Phylogenomic databases
HOGENOM	O73872.
HOVERGEN	O73872.
OMA	GPHFNPN.
Enzyme and pathway databases
BRENDA	1.15.1.1. 96826.
Gene expression databases
ArrayExpress	O73872.
Bgee	O73872.
Family and domain databases
InterPro	IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
ProDom	PD000469. SOD_CU_ZN. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_DANRE

Accession

Primary (citable) accession number: O73872

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	August 1, 1998
Last modified:	November 3, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project