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O73864 (WNT11_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-11
Gene names
Name:wnt11
Synonyms:wnt-11
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Developmental stage

Expressed during embryogenesis.

Post-translational modification

Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-79. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processKupffer's vesicle development

Inferred from genetic interaction PubMed 20843857. Source: ZFIN

camera-type eye development

Inferred from mutant phenotype PubMed 22773843PubMed 9007240. Source: ZFIN

cell migration

Inferred from mutant phenotype PubMed 9142986. Source: ZFIN

cell migration involved in gastrulation

Inferred from mutant phenotype PubMed 15630025PubMed 15996547PubMed 16019189PubMed 16198297PubMed 18701549. Source: ZFIN

cell-cell adhesion

Inferred from mutant phenotype PubMed 16198297PubMed 17130287. Source: ZFIN

central nervous system development

Inferred from mutant phenotype PubMed 9142986. Source: ZFIN

convergent extension

Inferred from genetic interaction PubMed 17906624PubMed 22773843. Source: ZFIN

convergent extension involved in gastrulation

Inferred from mutant phenotype PubMed 12062050PubMed 12676324PubMed 15815683PubMed 18701549. Source: ZFIN

embryonic eye morphogenesis

Inferred from mutant phenotype PubMed 15996547PubMed 9142986. Source: ZFIN

establishment of mitotic spindle orientation

Inferred from mutant phenotype PubMed 15254551. Source: ZFIN

eye field cell fate commitment involved in camera-type eye formation

Inferred from mutant phenotype PubMed 15996547. Source: ZFIN

gastrulation with mouth forming second

Inferred from mutant phenotype PubMed 15928205PubMed 16198297PubMed 9142986. Source: ZFIN

heart development

Inferred from mutant phenotype PubMed 15630025. Source: ZFIN

heart looping

Inferred from genetic interaction PubMed 20843857. Source: ZFIN

mediolateral intercalation

Inferred from mutant phenotype PubMed 10811221. Source: ZFIN

mesodermal cell migration

Inferred from mutant phenotype PubMed 18701549. Source: ZFIN

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of canonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell death

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell growth

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

neural plate morphogenesis

Inferred from mutant phenotype PubMed 15996547. Source: ZFIN

neuroendocrine cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

non-canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 15996547. Source: ZFIN

palate development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of Ras GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein kinase C signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein kinase activity

Inferred from sequence or structural similarity. Source: GOC

positive regulation of stress fiber assembly

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

protein localization

Inferred from genetic interaction PubMed 17130287. Source: ZFIN

protein localization to cell surface

Inferred from sequence or structural similarity. Source: UniProtKB

protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of endocytosis

Inferred from mutant phenotype PubMed 16198297. Source: ZFIN

regulation of protein kinase activity

Inferred from mutant phenotype PubMed 17611617. Source: ZFIN

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

plasma membrane

Inferred from direct assay PubMed 17130287. Source: ZFIN

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRas GTPase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

frizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein kinase activator activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 354331Protein Wnt-11
PRO_0000041469

Amino acid modifications

Lipidation791S-palmitoyl cysteine By similarity
Lipidation2151O-palmitoyl serine; by PORCN By similarity
Glycosylation321N-linked (GlcNAc...) Potential
Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O73864 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: D17615E576510A4C

FASTA35439,150
        10         20         30         40         50         60 
MTEYRNFLLL FITSLSVIYP CTGISWLGLT INGSSVGWNQ THHCKLLDGL VPDQQQLCKR 

        70         80         90        100        110        120 
NLELMHSIVR AARLTKSACT SSFSDMRWNW SSIESAPHFT PDLAKGTREA AFVVSLAAAV 

       130        140        150        160        170        180 
VSHAIARACA SGDLPSCSCA AMPSEQAAPD FRWGGCGDNL RYYGLQMGSA FSDAPMRNRR 

       190        200        210        220        230        240 
SGPQDFRLMQ LHNNAVGRQV LMDSLEMKCK CHGVSGSCSV KTCWKGLQDI STISADLKSK 

       250        260        270        280        290        300 
YLSATKVIPR QIGTRRQLVP REMEVRPVGE NELVYLVSSP DYCTQNAKQG SLGTTDRQCN 

       310        320        330        340        350 
KTASGSESCG LMCCGRGYNA YTEVLVERCQ CKYHWCCYVS CKTCKRTVER YVSK 

« Hide

References

[1]"Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and no tail activity."
Makita R., Mizuno T., Kuroiwa A., Koshida S., Takeda H.
Mech. Dev. 71:165-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF067429 mRNA. Translation: AAC17922.1.
UniGeneDr.75830.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-990603-12. wnt11.

Phylogenomic databases

eggNOGNOG273917.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidO73864.
PhylomeDBO73864.

Family and domain databases

InterProIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWNT11_DANRE
AccessionPrimary (citable) accession number: O73864
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families