Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O73864

- WNT11_DANRE

UniProt

O73864 - WNT11_DANRE

Protein

Protein Wnt-11

Gene

wnt11

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. protein kinase activator activity Source: UniProtKB
    3. Ras GTPase activator activity Source: UniProtKB
    4. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. camera-type eye development Source: ZFIN
    2. cell migration Source: ZFIN
    3. cell migration involved in gastrulation Source: ZFIN
    4. central nervous system development Source: ZFIN
    5. convergent extension Source: ZFIN
    6. convergent extension involved in axis elongation Source: ZFIN
    7. convergent extension involved in gastrulation Source: ZFIN
    8. embryonic eye morphogenesis Source: ZFIN
    9. establishment of mitotic spindle orientation Source: ZFIN
    10. eye field cell fate commitment involved in camera-type eye formation Source: ZFIN
    11. gastrulation with mouth forming second Source: ZFIN
    12. heart development Source: ZFIN
    13. heart looping Source: ZFIN
    14. Kupffer's vesicle development Source: ZFIN
    15. mediolateral intercalation Source: ZFIN
    16. mesodermal cell migration Source: ZFIN
    17. negative regulation of apoptotic process Source: UniProtKB
    18. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
    19. negative regulation of cell death Source: UniProtKB
    20. negative regulation of cell growth Source: UniProtKB
    21. negative regulation of cell migration Source: UniProtKB
    22. negative regulation of transcription, DNA-templated Source: UniProtKB
    23. neural plate morphogenesis Source: ZFIN
    24. neuroendocrine cell differentiation Source: UniProtKB
    25. neuron differentiation Source: RefGenome
    26. non-canonical Wnt signaling pathway Source: ZFIN
    27. palate development Source: UniProtKB
    28. positive regulation of cell migration Source: UniProtKB
    29. positive regulation of gene expression Source: UniProtKB
    30. positive regulation of protein kinase activity Source: GOC
    31. positive regulation of protein kinase C signaling Source: UniProtKB
    32. positive regulation of Ras GTPase activity Source: UniProtKB
    33. positive regulation of stress fiber assembly Source: UniProtKB
    34. positive regulation of transcription, DNA-templated Source: UniProtKB
    35. protein localization Source: ZFIN
    36. protein localization to cell surface Source: UniProtKB
    37. protein phosphorylation Source: UniProtKB
    38. regulation of endocytosis Source: ZFIN
    39. regulation of protein kinase activity Source: ZFIN
    40. single organismal cell-cell adhesion Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-11
    Gene namesi
    Name:wnt11
    Synonyms:wnt-11
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-990603-12. wnt11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular space Source: RefGenome
    3. plasma membrane Source: ZFIN
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 354331Protein Wnt-11PRO_0000041469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi129 ↔ 137By similarity
    Disulfide bondi139 ↔ 156By similarity
    Disulfide bondi209 ↔ 223By similarity
    Disulfide bondi211 ↔ 218By similarity
    Lipidationi215 – 2151O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi299 ↔ 314By similarity
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi329 ↔ 344By similarity
    Disulfide bondi331 ↔ 341By similarity
    Disulfide bondi336 ↔ 337By similarity

    Post-translational modificationi

    Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Expressioni

    Developmental stagei

    Expressed during embryogenesis.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG273917.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiO73864.
    PhylomeDBiO73864.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O73864-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEYRNFLLL FITSLSVIYP CTGISWLGLT INGSSVGWNQ THHCKLLDGL    50
    VPDQQQLCKR NLELMHSIVR AARLTKSACT SSFSDMRWNW SSIESAPHFT 100
    PDLAKGTREA AFVVSLAAAV VSHAIARACA SGDLPSCSCA AMPSEQAAPD 150
    FRWGGCGDNL RYYGLQMGSA FSDAPMRNRR SGPQDFRLMQ LHNNAVGRQV 200
    LMDSLEMKCK CHGVSGSCSV KTCWKGLQDI STISADLKSK YLSATKVIPR 250
    QIGTRRQLVP REMEVRPVGE NELVYLVSSP DYCTQNAKQG SLGTTDRQCN 300
    KTASGSESCG LMCCGRGYNA YTEVLVERCQ CKYHWCCYVS CKTCKRTVER 350
    YVSK 354
    Length:354
    Mass (Da):39,150
    Last modified:August 1, 1998 - v1
    Checksum:iD17615E576510A4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067429 mRNA. Translation: AAC17922.1.
    UniGeneiDr.75830.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067429 mRNA. Translation: AAC17922.1 .
    UniGenei Dr.75830.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ZFINi ZDB-GENE-990603-12. wnt11.

    Phylogenomic databases

    eggNOGi NOG273917.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi O73864.
    PhylomeDBi O73864.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and no tail activity."
      Makita R., Mizuno T., Kuroiwa A., Koshida S., Takeda H.
      Mech. Dev. 71:165-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiWNT11_DANRE
    AccessioniPrimary (citable) accession number: O73864
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3