O73864 (WNT11_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-11

Gene names

Name:	wnt11
Synonyms:	wnt-11

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Developmental stage	Expressed during embryogenesis.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome cell-cell adhesion Inferred from mutant phenotype. Source: ZFIN central nervous system development Inferred from mutant phenotype. Source: ZFIN endoderm development Inferred from Biological aspect of Ancestor. Source: RefGenome establishment of mitotic spindle orientation Inferred from mutant phenotype. Source: ZFIN eye field cell fate commitment involved in camera-type eye formation Inferred from mutant phenotype. Source: ZFIN gastrulation with mouth forming second Inferred from mutant phenotype. Source: ZFIN heart development Inferred from mutant phenotype. Source: ZFIN mediolateral intercalation Inferred from mutant phenotype. Source: ZFIN mesodermal cell migration Inferred from mutant phenotype. Source: ZFIN negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell growth Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB neural plate morphogenesis Inferred from mutant phenotype. Source: ZFIN neuroendocrine cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB non-canonical Wnt receptor signaling pathway Inferred from mutant phenotype. Source: ZFIN palate development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell migration Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein kinase C signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of stress fiber assembly Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB protein localization at cell surface Inferred from sequence or structural similarity. Source: UniProtKB protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB regulation of endocytosis Inferred from mutant phenotype. Source: ZFIN regulation of protein kinase activity Inferred from mutant phenotype. Source: ZFIN
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from direct assay. Source: ZFIN proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome Ras GTPase activator activity Inferred from sequence or structural similarity. Source: UniProtKB protein kinase activator activity Inferred from sequence or structural similarity. Source: UniProtKB transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 354	331	Protein Wnt-11		PRO_0000041469
Amino acid modifications
	Glycosylation	32	1	N-linked (GlcNAc...) Potential
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Glycosylation	89	1	N-linked (GlcNAc...) Potential
	Glycosylation	300	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O73864 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: D17615E576510A4C	FASTA	354	39,150
	10 20 30 40 50 60 MTEYRNFLLL FITSLSVIYP CTGISWLGLT INGSSVGWNQ THHCKLLDGL VPDQQQLCKR 70 80 90 100 110 120 NLELMHSIVR AARLTKSACT SSFSDMRWNW SSIESAPHFT PDLAKGTREA AFVVSLAAAV 130 140 150 160 170 180 VSHAIARACA SGDLPSCSCA AMPSEQAAPD FRWGGCGDNL RYYGLQMGSA FSDAPMRNRR 190 200 210 220 230 240 SGPQDFRLMQ LHNNAVGRQV LMDSLEMKCK CHGVSGSCSV KTCWKGLQDI STISADLKSK 250 260 270 280 290 300 YLSATKVIPR QIGTRRQLVP REMEVRPVGE NELVYLVSSP DYCTQNAKQG SLGTTDRQCN 310 320 330 340 350 KTASGSESCG LMCCGRGYNA YTEVLVERCQ CKYHWCCYVS CKTCKRTVER YVSK

References

[1]	"Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and no tail activity." Makita R., Mizuno T., Kuroiwa A., Koshida S., Takeda H. Mech. Dev. 71:165-176(1998) [PubMed: 9507106] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF067429 mRNA. Translation: AAC17922.1.
IPI	IPI00481789.
UniGene	Dr.75830.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O73864.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ZFIN	ZDB-GENE-990603-12. wnt11.
Phylogenomic databases
eggNOG	fiNOG11575.
GeneTree	ENSGT00560000076960.
HOGENOM	HBG446188.
HOVERGEN	HBG001595.
InParanoid	O73864.
OrthoDB	EOG4MPHS2.
Gene expression databases
ArrayExpress	O73864.
Bgee	O73864.
Family and domain databases
InterPro	IPR005817. Wnt. IPR018161. Wnt_grthfactor_CS. [Graphical view]
PANTHER	PTHR12027. Wnt. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

WNT11_DANRE

Accession

Primary (citable) accession number: O73864

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program