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Protein

Protein Wnt-11

Gene

wnt11

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: ZFIN
  • cell migration Source: ZFIN
  • cell migration involved in gastrulation Source: ZFIN
  • central nervous system development Source: ZFIN
  • convergent extension Source: ZFIN
  • convergent extension involved in axis elongation Source: ZFIN
  • convergent extension involved in gastrulation Source: ZFIN
  • embryonic eye morphogenesis Source: ZFIN
  • establishment of mitotic spindle orientation Source: ZFIN
  • eye field cell fate commitment involved in camera-type eye formation Source: ZFIN
  • gastrulation with mouth forming second Source: ZFIN
  • heart development Source: ZFIN
  • heart looping Source: ZFIN
  • Kupffer's vesicle development Source: ZFIN
  • mediolateral intercalation Source: ZFIN
  • mesodermal cell migration Source: ZFIN
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • negative regulation of cell death Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • neural plate morphogenesis Source: ZFIN
  • neuroendocrine cell differentiation Source: UniProtKB
  • neuron differentiation Source: GO_Central
  • non-canonical Wnt signaling pathway Source: ZFIN
  • palate development Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of protein kinase activity Source: GOC
  • positive regulation of protein kinase C signaling Source: UniProtKB
  • positive regulation of stress fiber assembly Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein localization Source: ZFIN
  • protein localization to cell surface Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of endocytosis Source: ZFIN
  • regulation of protein kinase activity Source: ZFIN
  • single organismal cell-cell adhesion Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Gene namesi
Name:wnt11
Synonyms:wnt-11
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990603-12. wnt11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular space Source: GO_Central
  • plasma membrane Source: ZFIN
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 354331Protein Wnt-11PRO_0000041469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi129 ↔ 137By similarity
Disulfide bondi139 ↔ 156By similarity
Disulfide bondi209 ↔ 223By similarity
Disulfide bondi211 ↔ 218By similarity
Lipidationi215 – 2151O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi299 ↔ 314By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi329 ↔ 344By similarity
Disulfide bondi331 ↔ 341By similarity
Disulfide bondi336 ↔ 337By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Expressioni

Developmental stagei

Expressed during embryogenesis.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO73864.
PhylomeDBiO73864.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYRNFLLL FITSLSVIYP CTGISWLGLT INGSSVGWNQ THHCKLLDGL
60 70 80 90 100
VPDQQQLCKR NLELMHSIVR AARLTKSACT SSFSDMRWNW SSIESAPHFT
110 120 130 140 150
PDLAKGTREA AFVVSLAAAV VSHAIARACA SGDLPSCSCA AMPSEQAAPD
160 170 180 190 200
FRWGGCGDNL RYYGLQMGSA FSDAPMRNRR SGPQDFRLMQ LHNNAVGRQV
210 220 230 240 250
LMDSLEMKCK CHGVSGSCSV KTCWKGLQDI STISADLKSK YLSATKVIPR
260 270 280 290 300
QIGTRRQLVP REMEVRPVGE NELVYLVSSP DYCTQNAKQG SLGTTDRQCN
310 320 330 340 350
KTASGSESCG LMCCGRGYNA YTEVLVERCQ CKYHWCCYVS CKTCKRTVER

YVSK
Length:354
Mass (Da):39,150
Last modified:August 1, 1998 - v1
Checksum:iD17615E576510A4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067429 mRNA. Translation: AAC17922.1.
UniGeneiDr.75830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067429 mRNA. Translation: AAC17922.1.
UniGeneiDr.75830.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990603-12. wnt11.

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO73864.
PhylomeDBiO73864.

Miscellaneous databases

PROiO73864.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and no tail activity."
    Makita R., Mizuno T., Kuroiwa A., Koshida S., Takeda H.
    Mech. Dev. 71:165-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiWNT11_DANRE
AccessioniPrimary (citable) accession number: O73864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: April 29, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.