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O73864

- WNT11_DANRE

UniProt

O73864 - WNT11_DANRE

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Protein

Protein Wnt-11

Gene

wnt11

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: RefGenome
  2. protein kinase activator activity Source: UniProtKB
  3. Ras GTPase activator activity Source: UniProtKB
  4. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. camera-type eye development Source: ZFIN
  2. cell migration Source: ZFIN
  3. cell migration involved in gastrulation Source: ZFIN
  4. central nervous system development Source: ZFIN
  5. convergent extension Source: ZFIN
  6. convergent extension involved in axis elongation Source: ZFIN
  7. convergent extension involved in gastrulation Source: ZFIN
  8. embryonic eye morphogenesis Source: ZFIN
  9. establishment of mitotic spindle orientation Source: ZFIN
  10. eye field cell fate commitment involved in camera-type eye formation Source: ZFIN
  11. gastrulation with mouth forming second Source: ZFIN
  12. heart development Source: ZFIN
  13. heart looping Source: ZFIN
  14. Kupffer's vesicle development Source: ZFIN
  15. mediolateral intercalation Source: ZFIN
  16. mesodermal cell migration Source: ZFIN
  17. negative regulation of apoptotic process Source: UniProtKB
  18. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  19. negative regulation of cell death Source: UniProtKB
  20. negative regulation of cell growth Source: UniProtKB
  21. negative regulation of cell migration Source: UniProtKB
  22. negative regulation of transcription, DNA-templated Source: UniProtKB
  23. neural plate morphogenesis Source: ZFIN
  24. neuroendocrine cell differentiation Source: UniProtKB
  25. neuron differentiation Source: RefGenome
  26. non-canonical Wnt signaling pathway Source: ZFIN
  27. palate development Source: UniProtKB
  28. positive regulation of cell migration Source: UniProtKB
  29. positive regulation of gene expression Source: UniProtKB
  30. positive regulation of protein kinase activity Source: GOC
  31. positive regulation of protein kinase C signaling Source: UniProtKB
  32. positive regulation of Ras GTPase activity Source: UniProtKB
  33. positive regulation of stress fiber assembly Source: UniProtKB
  34. positive regulation of transcription, DNA-templated Source: UniProtKB
  35. protein localization Source: ZFIN
  36. protein localization to cell surface Source: UniProtKB
  37. protein phosphorylation Source: UniProtKB
  38. regulation of endocytosis Source: ZFIN
  39. regulation of protein kinase activity Source: ZFIN
  40. single organismal cell-cell adhesion Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-11
Gene namesi
Name:wnt11
Synonyms:wnt-11
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990603-12. wnt11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: RefGenome
  3. plasma membrane Source: ZFIN
  4. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 354331Protein Wnt-11PRO_0000041469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi129 ↔ 137By similarity
Disulfide bondi139 ↔ 156By similarity
Disulfide bondi209 ↔ 223By similarity
Disulfide bondi211 ↔ 218By similarity
Lipidationi215 – 2151O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi299 ↔ 314By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi329 ↔ 344By similarity
Disulfide bondi331 ↔ 341By similarity
Disulfide bondi336 ↔ 337By similarity

Post-translational modificationi

Palmitoylation at Ser-215 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Expressioni

Developmental stagei

Expressed during embryogenesis.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG273917.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO73864.
PhylomeDBiO73864.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73864-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEYRNFLLL FITSLSVIYP CTGISWLGLT INGSSVGWNQ THHCKLLDGL
60 70 80 90 100
VPDQQQLCKR NLELMHSIVR AARLTKSACT SSFSDMRWNW SSIESAPHFT
110 120 130 140 150
PDLAKGTREA AFVVSLAAAV VSHAIARACA SGDLPSCSCA AMPSEQAAPD
160 170 180 190 200
FRWGGCGDNL RYYGLQMGSA FSDAPMRNRR SGPQDFRLMQ LHNNAVGRQV
210 220 230 240 250
LMDSLEMKCK CHGVSGSCSV KTCWKGLQDI STISADLKSK YLSATKVIPR
260 270 280 290 300
QIGTRRQLVP REMEVRPVGE NELVYLVSSP DYCTQNAKQG SLGTTDRQCN
310 320 330 340 350
KTASGSESCG LMCCGRGYNA YTEVLVERCQ CKYHWCCYVS CKTCKRTVER

YVSK
Length:354
Mass (Da):39,150
Last modified:August 1, 1998 - v1
Checksum:iD17615E576510A4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067429 mRNA. Translation: AAC17922.1.
UniGeneiDr.75830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF067429 mRNA. Translation: AAC17922.1 .
UniGenei Dr.75830.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-990603-12. wnt11.

Phylogenomic databases

eggNOGi NOG273917.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi O73864.
PhylomeDBi O73864.

Family and domain databases

InterProi IPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and no tail activity."
    Makita R., Mizuno T., Kuroiwa A., Koshida S., Takeda H.
    Mech. Dev. 71:165-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiWNT11_DANRE
AccessioniPrimary (citable) accession number: O73864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3