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O73853

- CP17A_ICTPU

UniProt

O73853 - CP17A_ICTPU

Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

cyp17a1

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

    Catalytic activityi

    A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
    17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi445 – 4451Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. steroid 17-alpha-monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. steroid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
    Alternative name(s):
    17-alpha-hydroxyprogesterone aldolase
    CYPXVII
    Cytochrome P450 17A1
    Cytochrome P450-C17
    Short name:
    Cytochrome P450c17
    Gene namesi
    Name:cyp17a1
    Synonyms:cyp17
    OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)
    Taxonomic identifieri7998 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus

    Subcellular locationi

    Membrane Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051945Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO73853.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O73853-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWLICFCVF AAIIIVALYL RKIHGFLVDD RAPPNLPSLP IIGSLLSINS    50
    NSPPHIFFQQ LQKKYGDIYS LDMGSNRVII VNNHHHAKEV LLRKGKIFAG 100
    RPRTVTTDIL TRDGKDIAFG DYSATWKFHR KIVHGALCMF GEGTASIEKI 150
    ICREASSMCE ILTNLQSSAA DLAPELTRAV TNVVCTLCFS SSYKRGDPEF 200
    EAMLKYSQGI VDTVAKDSLV DIFPWLQLFP NEDLRILRRC VSIRDKLLQK 250
    KYEEHKADFS DNIQRDLFDA LLRAKNSSEN NNTSTQDVGL TDDHLLMTVG 300
    DIFGAGVETT TTVLKWSILY LIHHPQVQRK IQEELDAKIG RDRHPQVNDR 350
    GNLPYLEATI REVLRIRPVS PLLIPHVALS DANIGEYTVQ KGTRVIVNLW 400
    SLHHDEKEWK NPELFNPERF LNEEGNSLCC PSLSYLPFGA GVRVCLGEAL 450
    AKLELFLFLS WILQRFTLEV PGGQPLPELQ GKFRVVLQPQ KYKVIARLRT 500
    GWEKSLQSQE SESG 514
    Length:514
    Mass (Da):58,134
    Last modified:August 1, 1998 - v1
    Checksum:i7CDF5CC0F6982053
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063837 mRNA. Translation: AAC16551.1.
    RefSeqiNP_001187242.1. NM_001200313.1.
    UniGeneiIpu.32457.

    Genome annotation databases

    GeneIDi100313515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF063837 mRNA. Translation: AAC16551.1 .
    RefSeqi NP_001187242.1. NM_001200313.1.
    UniGenei Ipu.32457.

    3D structure databases

    ProteinModelPortali O73853.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100313515.

    Organism-specific databases

    CTDi 100313515.

    Phylogenomic databases

    HOVERGENi HBG106944.

    Enzyme and pathway databases

    UniPathwayi UPA00062 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and heterologous expression of the cDNA encoding the cytochrome P450 17-hydroxylase from the channel catfish (Ictalurus punctatus)."
      Trant J.M., Berard C., Byrne B.J., Wunder J.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP17A_ICTPU
    AccessioniPrimary (citable) accession number: O73853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3