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O73853

- CP17A_ICTPU

UniProt

O73853 - CP17A_ICTPU

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene
cyp17a1, cyp17
Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

Heme group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi445 – 4451Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:cyp17a1
Synonyms:cyp17
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus

Subcellular locationi

Membrane Reviewed prediction

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051945Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO73853.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73853-1 [UniParc]FASTAAdd to Basket

« Hide

MGWLICFCVF AAIIIVALYL RKIHGFLVDD RAPPNLPSLP IIGSLLSINS    50
NSPPHIFFQQ LQKKYGDIYS LDMGSNRVII VNNHHHAKEV LLRKGKIFAG 100
RPRTVTTDIL TRDGKDIAFG DYSATWKFHR KIVHGALCMF GEGTASIEKI 150
ICREASSMCE ILTNLQSSAA DLAPELTRAV TNVVCTLCFS SSYKRGDPEF 200
EAMLKYSQGI VDTVAKDSLV DIFPWLQLFP NEDLRILRRC VSIRDKLLQK 250
KYEEHKADFS DNIQRDLFDA LLRAKNSSEN NNTSTQDVGL TDDHLLMTVG 300
DIFGAGVETT TTVLKWSILY LIHHPQVQRK IQEELDAKIG RDRHPQVNDR 350
GNLPYLEATI REVLRIRPVS PLLIPHVALS DANIGEYTVQ KGTRVIVNLW 400
SLHHDEKEWK NPELFNPERF LNEEGNSLCC PSLSYLPFGA GVRVCLGEAL 450
AKLELFLFLS WILQRFTLEV PGGQPLPELQ GKFRVVLQPQ KYKVIARLRT 500
GWEKSLQSQE SESG 514
Length:514
Mass (Da):58,134
Last modified:August 1, 1998 - v1
Checksum:i7CDF5CC0F6982053
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063837 mRNA. Translation: AAC16551.1.
RefSeqiNP_001187242.1. NM_001200313.1.
UniGeneiIpu.32457.

Genome annotation databases

GeneIDi100313515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063837 mRNA. Translation: AAC16551.1 .
RefSeqi NP_001187242.1. NM_001200313.1.
UniGenei Ipu.32457.

3D structure databases

ProteinModelPortali O73853.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100313515.

Organism-specific databases

CTDi 100313515.

Phylogenomic databases

HOVERGENi HBG106944.

Enzyme and pathway databases

UniPathwayi UPA00062 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and heterologous expression of the cDNA encoding the cytochrome P450 17-hydroxylase from the channel catfish (Ictalurus punctatus)."
    Trant J.M., Berard C., Byrne B.J., Wunder J.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP17A_ICTPU
AccessioniPrimary (citable) accession number: O73853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: December 11, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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